Neural mechanisms of context-dependent processing of CO<sub>2</sub> avoidance behavior in fruit flies

Siju, K.P.; Bräcker, Lasse B.; Kadow, Ilona C. Grunwald

doi:10.4161/fly.28000

Cited by 14 publications

(10 citation statements)

References 34 publications

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“…Either finding would be novel compared to Ir expression patterns in D. melanogaster 9 and suggest potential functional distinctions between fruit flies and mosquitoes. Conversely, novel AgIr expression could indicate that these genes perform as yet uncharacterized roles as sensors of endogenous chemical cues such as biogenic amines or neuropeptides that are thought to modulate mosquito odor responses35363738.…”

Section: Discussionmentioning

confidence: 99%

Variant Ionotropic Receptors in the Malaria Vector Mosquito Anopheles gambiae Tuned to Amines and Carboxylic Acids

Pitts

Derryberry

Zhang

et al. 2017

Sci Rep

119

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The principal Afrotropical human malaria vector mosquito, Anopheles gambiae, remains a significant threat to global health. A critical component in the transmission of malaria is the ability of An. gambiae females to detect and respond to human-derived chemical kairomones in their search for blood meal hosts. The basis for host odor responses resides in olfactory receptor neurons (ORNs) that express chemoreceptors encoded by large gene families, including the odorant receptors (ORs) and the variant ionotropic receptors (IRs). While ORs have been the focus of extensive investigation, functional IR complexes and the chemical compounds that activate them have not been identified in An. gambiae. Here we report the transcriptional profiles and functional characterization of three An. gambiae IR (AgIr) complexes that specifically respond to amines or carboxylic acids - two classes of semiochemicals that have been implicated in mediating host-seeking by adult females but are not known to activate An. gambiae ORs (AgOrs). Our results suggest that AgIrs play critical roles in the detection and behavioral responses to important classes of host odors that are underrepresented in the AgOr chemical space.

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Section: Discussionmentioning

confidence: 99%

Variant Ionotropic Receptors in the Malaria Vector Mosquito Anopheles gambiae Tuned to Amines and Carboxylic Acids

Pitts

Derryberry

Zhang

et al. 2017

Sci Rep

119

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“…At this point, we know most about their role as teaching signals during associative appetitive and aversive memory formation (see for instance Yamagata et al, 2015 ). Nevertheless, they do modulate behavior instantaneously (Lewis et al, 2015 ), and potentially play a much greater role in internal state-dependent olfactory processing and behavior as previously thought (Krashes et al, 2009 ; Siju et al, 2014 ; Cohn et al, 2015 ). Finally, to date little is known about the neurons downstream of MBONs and upstream of DANs.…”

Section: Introductionmentioning

confidence: 94%

Internal State Dependent Odor Processing and Perception—The Role of Neuromodulation in the Fly Olfactory System

Sayın

Boehm

Kobler

et al. 2018

Front. Cell. Neurosci.

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Animals rely heavily on their sense of olfaction to perform various vital interactions with an ever-in-flux environment. The turbulent and combinatorial nature of air-borne odorant cues demands the employment of various coding strategies, which allow the animal to attune to its internal needs and past or present experiences. Furthermore, these internal needs can be dependent on internal states such as hunger, reproductive state and sickness. Neuromodulation is a key component providing flexibility under such conditions. Understanding the contributions of neuromodulation, such as sensory neuron sensitization and choice bias requires manipulation of neuronal activity on a local and global scale. With Drosophila's genetic toolset, these manipulations are feasible and even allow a detailed look on the functional role of classical neuromodulators such as dopamine, octopamine and neuropeptides. The past years unraveled various mechanisms adapting chemosensory processing and perception to internal states such as hunger and reproductive state. However, future research should also investigate the mechanisms underlying other internal states including the modulatory influence of endogenous microbiota on Drosophila behavior. Furthermore, sickness induced by pathogenic infection could lead to novel insights as to the neuromodulators of circuits that integrate such a negative postingestive signal within the circuits governing olfactory behavior and learning. The enriched emporium of tools Drosophila provides will help to build a concrete picture of the influence of neuromodulation on olfaction and metabolism, adaptive behavior and our overall understanding of how a brain works.

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“…235 Under different conditions, such as hunger, the brain processes the CO 2 stress cues via specific neural pathways, indicating dSO is a robust, contextdependent signal. 236 The olfactory pathway is important for "responder" flies to react to dSO. However, these are not the same brain structures that are involved in olfactory learning.…”

Section: Response To Stressed Fliesmentioning

confidence: 99%

Social behavior and aging: A fly model

Brenman-Suttner

Yost

Frame

et al. 2019

Genes Brain and Behavior

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The field of behavioral genetics has recently begun to explore the effect of age on social behaviors. Such studies are particularly important, as certain neuropsychiatric disorders with abnormal social interactions, like autism and schizophrenia, have been linked to older parents. Appropriate social interaction can also have a positive impact on longevity, and is associated with successful aging in humans. Currently, there are few genetic models for understanding the effect of aging on social behavior and its potential transgenerational inheritance. The fly is emerging as a powerful model for identifying the basic molecular mechanisms underlying neurological and neuropsychiatric disorders. In this review, we discuss these recent advancements, with a focus on how studies in Drosophila melanogaster have provided insight into the effect of aging on aspects of social behavior, including across generations.

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Neural mechanisms of context-dependent processing of CO₂ avoidance behavior in fruit flies

Cited by 14 publications

References 34 publications

Variant Ionotropic Receptors in the Malaria Vector Mosquito Anopheles gambiae Tuned to Amines and Carboxylic Acids

Variant Ionotropic Receptors in the Malaria Vector Mosquito Anopheles gambiae Tuned to Amines and Carboxylic Acids

Internal State Dependent Odor Processing and Perception—The Role of Neuromodulation in the Fly Olfactory System

Social behavior and aging: A fly model

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Neural mechanisms of context-dependent processing of CO2 avoidance behavior in fruit flies

Cited by 14 publications

References 34 publications

Variant Ionotropic Receptors in the Malaria Vector Mosquito Anopheles gambiae Tuned to Amines and Carboxylic Acids

Variant Ionotropic Receptors in the Malaria Vector Mosquito Anopheles gambiae Tuned to Amines and Carboxylic Acids

Internal State Dependent Odor Processing and Perception—The Role of Neuromodulation in the Fly Olfactory System

Social behavior and aging: A fly model

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Product

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Neural mechanisms of context-dependent processing of CO₂ avoidance behavior in fruit flies