Neural Mechanisms of Pain: an Overview

Casey, Kenneth L.

doi:10.1111/j.1399-6576.1982.tb01838.x

Cited by 18 publications

(1 citation statement)

References 61 publications

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“…The discriminative component of pain sensations includes the ability to identify a stimulus as originating from somatic or visceral tissue, to inform about the physical properties of the stimulus along a continuum of intensities, and to localize it in space and time. Of particular importance for the extraction of information on the stimulus is the primary nociceptive neuron, which serves transduction and transformation processes and transmits the information to the next level of integrating neurons in the CNS [ 1 ]. The first recordings from nociceptive nerve fibers were pioneered by Yngve Zotterman [ 2 ] and Ainsley Iggo [ 3 ] in nonhuman species followed by microneurography recordings from human nociceptive afferents by Hagbarth and Vallbo [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Towards bridging the translational gap by improved modeling of human nociception in health and disease

Zeidler

Kummer

Kress

2022

Pflugers Arch - Eur J Physiol

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Despite numerous studies which have explored the pathogenesis of pain disorders in preclinical models, there is a pronounced translational gap, which is at least partially caused by differences between the human and rodent nociceptive system. An elegant way to bridge this divide is the exploitation of human-induced pluripotent stem cell (iPSC) reprogramming into human iPSC-derived nociceptors (iDNs). Several protocols were developed and optimized to model nociceptive processes in health and disease. Here we provide an overview of the different approaches and summarize the knowledge obtained from such models on pain pathologies associated with monogenetic sensory disorders so far. In addition, novel perspectives offered by increasing the complexity of the model systems further to better reflect the natural environment of nociceptive neurons by involving other cell types in 3D model systems are described.

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