Neural Mechanisms Underlying the Coughing Reflex

Lu, Haicheng; Cao, Peng

doi:10.1007/s12264-023-01104-y

Cited by 7 publications

(4 citation statements)

References 130 publications

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“…Therefore, in this review, to keep the focus on Bordetellainduced cough, the author introduces only basic knowledge of the general coughing mechanism and refers readers to other authoritative reviews for a detailed description of the physiology of cough. [6][7][8][9]…”

Section: Overviews Of Coughmentioning

confidence: 99%

“…Cellular factors involved in evoking cough [7][8][9][10][11] Ion channels expressed on sensory nerves and surrounding tissues are considered to generate an action potential on sensory neurons to cause the cough reflex. Of these, transient receptor potential (TRP) channels, which conduct cations in response to extracellular stimuli, including temperatures, chemicals, stretch, pH, osmolarity, and others, have been the primary focus of studies in relation to cough events.…”

Section: Neurophysiology Of Coughmentioning

confidence: 99%

“…Moreover, previous studies have underscored the variation in coughing mechanisms across different animal species and sexes in the presence or absence of anesthesia and with respect to the type of stimuli used. Therefore, in this review, to keep the focus on Bordetella ‐induced cough, the author introduces only basic knowledge of the general coughing mechanism and refers readers to other authoritative reviews for a detailed description of the physiology of cough 6–9 …”

Section: Overviews Of Coughmentioning

confidence: 99%

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Current understanding of Bordetella‐induced cough

Horiguchi

2024

Microbiology and Immunology

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Typical pathogenic bacteria of the genus Bordetella cause respiratory diseases, many of which are characterized by severe coughing in host animals. In human infections with these bacteria, such as whooping cough, coughing imposes a heavy burden on patients. The pathophysiology of this severe coughing had long been uncharacterized because convenient animal models that reproduce Bordetella‐induced cough have not been available. However, rat and mouse models were recently shown as useful for understanding, at least partially, the causative factors and the mechanism of Bordetella‐induced cough. Many types of coughs are induced under various physiological conditions, and the neurophysiological pathways of coughing are considered to vary among animal species, including humans. However, the neurophysiological mechanisms of the coughs in different animal species have not been entirely understood, and, accordingly, the current understanding of Bordetella‐induced cough is still incomplete. Nevertheless, recent research findings may open the way for the development of prophylaxis and therapeutic measures against Bordetella‐induced cough.

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Section: Overviews Of Coughmentioning

confidence: 99%

Section: Neurophysiology Of Coughmentioning

confidence: 99%

Section: Overviews Of Coughmentioning

confidence: 99%

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Current understanding of Bordetella‐induced cough

Horiguchi

2024

Microbiology and Immunology

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“…Cough is typically initiated as a reflex event from stimulation of pulmonary cough receptors and activation of vagal afferent nerves [38,39]. During the expiratory phase, high-speed airflow transfers momentum to accumulated mucus, propelling it toward the upper airways.…”

Section: Role Of Cough In Pulmonary Healthmentioning

confidence: 99%

Cough in non-cystic fibrosis bronchiectasis

Kantar,

Song,

Bush

et al. 2024

ERJ Open Res

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Non-cystic fibrosis bronchiectasis (NCFBE) belongs to the spectrum of chronic suppurative lung diseases and is characterised by persistent wet/sputum-productive cough and airway dilatation. Morphological and structural changes in the airways lead to changes in airflow, impair breathing-induced mucus transport and sliding, and reduce the shear forces of cough. Moreover, mucus hyperviscosity contributes to compromised ciliary activity and the pathogenesis of the disease. This review highlights the role of cough in NCFBE, especially with respect to mucus clearance.Cough is the principal backup mechanism when mucus clearance is impaired due to either or both reduced function of cilia- and breathing-induced mucus transport, as well as abnormal mucus. The efficiency of cough in overcoming the cohesive and adhesive properties of mucus is determined by both the forces applied to mucus by airflow and the mucus-airway surface properties.In NCFBE, mucus hyperviscosity contributes to impaired mucus clearance and confers to disease pathogenesis; therefore, it may be a therapeutic target. The primary objectives of physiotherapy regimens in NCFBE are mucus hydration and the establishment of an optimal expiratory airflow velocity, which exerts shearing forces on the mucus located on the airway surface. Modifying the rheological properties of mucus and enhancing its transport whenever possible (by breathing manoeuvres, ciliary activity, and cough) represent prime goals in preventing disease progression and indeed reversing bronchiectasis in the early stages of the disease, as well as preventing pulmonary exacerbations.

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