“…However, this technique encounters several problems due to the low definition in some edges of the tissues and organs (Alén et al, 2006;Fujii et al, 2013;Fakhrzadeh et al, 2013). On the other hand, classification and recognition process are based on: (i) clustering methods such as K-means, mean shift, K-nn, among others are employed for histological image segmentation (Wu et al, 2015;He et al, 2011); (ii) SVM, Bayesian networks and another machine learning algorithms are used to characterise and classify healthy and pathology cells, tissues and organs (d. A. Zampirolli et al, 2010;Krishnan et al, 2010;Veillard et al, 2012); (iii) neural networks are used to the classification task producing good results on automatically learned features (Bevilacqua et al, 2015;Jitaree et al, 2013;Kashif et al, 2016); (iv) learning based approach using bag-of-words model, this method is attractive as it offers good classification accuracy at low computation cost than the texture-feature-based methods (Galaro et al, 2011;Nguyen et al, 2015;Cheng et al, 2012). However, some of these works are focus in histopathologic images which have different characteristics to healthy tissues.…”