Autonomous underwater vehicles (AUVs) are widely used to accomplish various missions in the complex marine environment; the design of a control system for AUVs is particularly difficult due to the high nonlinearity, variations in hydrodynamic coefficients, and external force from ocean currents. In this paper, we propose a controller based on deep reinforcement learning (DRL) in a simulation environment for studying the control performance of the vectored thruster AUV. RL is an important method of artificial intelligence that can learn behavior through trial-and-error interactions with the environment, so it does not need to provide an accurate AUV control model that is very hard to establish. The proposed RL algorithm only uses the information that can be measured by sensors inside the AUVs as the input parameters, and the outputs of the designed controller are the continuous control actions, which are the commands that are set to the vectored thruster. Moreover, a reward function is developed for deep RL controller considering different factors which actually affect the control accuracy of AUV navigation control. To confirm the algorithm’s effectiveness, a series of simulations are carried out in the designed simulation environment, which is a method to save time and improve efficiency. Simulation results prove the feasibility of the deep RL algorithm applied to the control system for AUV. Furthermore, our work also provides an optional method for robot control problems to deal with improving technology requirements and complicated application environments.