Neural Precursor Cell-Derived Pleiotrophin Mediates Glioma Invasion of the Subventricular Zone

Qin, Elizabeth Y.; Cooper, Dominique D.; Abbott, Keene L.; Lennon, James; Nagaraja, Surya; Mackay, Alan; Jones, Chris; Vogel, Hannes; Jackson, Peter K.; Monje, Michelle

doi:10.2139/ssrn.3155610

Cited by 1 publication

(5 citation statements)

References 8 publications

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“…However, ptn expression is restricted to r5 and r6 and thus requires long-ranged transport to reach r1 to r4. Previous studies had reported that MDK and PTN act at considerable distances from their source (Olmeda et al, 2017;Qin et al, 2017;Shi et al, 2017) implying long range diffusion despite efficient heparin-binding. Importantly, such diffusion dynamics of MDK/PTN in vivo remained unknown.…”

Section: Mdka and Ptn Diffuse Over Long Distances To Interact With Pt...mentioning

confidence: 99%

“…Another proposed target of PTPRZ1b is Rho/ROCK signaling (Bhaduri et al, 2020;Qin et al, 2017). Interestingly in zebrafish, noncanonical Wnt/PCP signaling has been shown to control Rho/ROCK activity to facilitate convergence and extension during gastrulation (Bai et al, 2014;Marlow et al, 2002;Zhu et al, 2006).…”

Section: Mdka-ptprz1b Signaling Acts Upstream Of the Pcp Component Pr...mentioning

confidence: 99%

“…Cues that act upstream of Wnt/PCP to control cell polarity and positioning of Cdivisions, however, remain poorly understood (Hirano et al, 2022). Midkine (MDK) and pleiotrophin (PTN) are highly conserved heparin-binding growth factors implicated in various processes in the nervous system, including neuronal maturation (Tang et al, 2019), neurite outgrowth (Kaneda et al, 1996b;Kinnunen et al, 1996), cell migration (Maeda and Noda, 1998), and metastasis (Olmeda et al, 2017;Qin et al, 2017;Shi et al, 2017). Earlier studies proposed chondroitin sulfate side chains of the protein tyrosine phosphatase receptor type Z1 (PTPRZ1) as possible binding sites for human MDK and PTN (Maeda et al, 1999;Maeda et al, 1996), but evidence supporting such interactions in vivo is lacking.…”

Section: Introductionmentioning

confidence: 99%

“…Earlier studies proposed chondroitin sulfate side chains of the protein tyrosine phosphatase receptor type Z1 (PTPRZ1) as possible binding sites for human MDK and PTN (Maeda et al, 1999;Maeda et al, 1996), but evidence supporting such interactions in vivo is lacking. Cell culture and cancer studies suggested that downstream targets of MDK/PTN-PTPRZ1 signaling play a role in cytoskeletal remodeling and cell adhesion (Kuboyama et al, 2015;Meng et al, 2000;Qin et al, 2017;Shi et al, 2017). In glioma, PTN-PTPRZ1 signaling facilitates tumor invasion by activating Rho/ROCK signaling and triggering neural stem celllike mitotic behavior (Bhaduri et al, 2020;Qin et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Cell culture and cancer studies suggested that downstream targets of MDK/PTN-PTPRZ1 signaling play a role in cytoskeletal remodeling and cell adhesion (Kuboyama et al, 2015;Meng et al, 2000;Qin et al, 2017;Shi et al, 2017). In glioma, PTN-PTPRZ1 signaling facilitates tumor invasion by activating Rho/ROCK signaling and triggering neural stem celllike mitotic behavior (Bhaduri et al, 2020;Qin et al, 2017). Recent studies also revealed that PTN-PTPRZ1 regulates mitosis of human outer radial glial (oRG) cells, to maintain their stemness (Bhaduri et al, 2020;Pollen et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Midkine and Ptprz1b act upstream of Wnt planar cell polarity to establish a midline in the developing zebrafish hindbrain

Le,

Rajasekhar,

Loo

et al. 2023

Preprint

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A midline in the developing central nervous system (CNS) is essential for the symmetric distribution of neural progenitors that later establish functional, bilaterally symmetric neural circuits. In the zebrafish hindbrain, a midline forms early during neurulation and requires a coordinated interplay of cell convergence and midline-crossing cell divisions (C-divisions). These two processes are controlled by the Wnt/planar cell polarity (PCP) pathway. However, upstream cues that control the timely production of PCP components remain unknown. Midkine (Mdk) and pleiotrophin (Ptn) are structurally related heparin-binding growth factors that are dynamically expressed in the developing zebrafish hindbrain. We used proximity ligation assays (PLAs) and fluorescence cross correlation spectroscopy (FCCS)in vivoto show that two zebrafish Mdks, Mdka and Mdkb, as well as Ptn interact with protein tyrosine phosphatase receptors type Z1, Ptprz1a and Ptprz1b, with distinct affinities. Ligand binding triggered Ptprz1b internalization and thereby determined the availability of signaling receptor on cell membranes. In zebrafishmdka, ptnandptprz1bmutants, cell migration and convergence were significantly impaired during hindbrain neurulation. Impaired convergence led to misplaced C-divisions, defective cell polarity and consequently duplicated midlines. These duplications were rescued by overexpression ofDrosophilaPrickle, a key component of the Wnt/PCP pathway. Here, we provide evidence that zygotic Mdka controls the distribution of maternally provided Ptprz1b, which in turn is needed for transcription of zebrafishprickle1b. Our findings thus reveal a role for Mdka and Ptprz1b upstream of Wnt/PCP to coordinate neural plate convergence, neural progenitor positioning and midline formation.

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Section: Mdka and Ptn Diffuse Over Long Distances To Interact With Pt...mentioning

confidence: 99%

Section: Mdka-ptprz1b Signaling Acts Upstream Of the Pcp Component Pr...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Midkine and Ptprz1b act upstream of Wnt planar cell polarity to establish a midline in the developing zebrafish hindbrain

Le,

Rajasekhar,

Loo

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Neural Precursor Cell-Derived Pleiotrophin Mediates Glioma Invasion of the Subventricular Zone

Cited by 1 publication

References 8 publications

Midkine and Ptprz1b act upstream of Wnt planar cell polarity to establish a midline in the developing zebrafish hindbrain

Midkine and Ptprz1b act upstream of Wnt planar cell polarity to establish a midline in the developing zebrafish hindbrain

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