Neural prostheses

Procházka, A.; Mushahwar, Vivian K.; McCreery, Douglas B.

doi:10.1111/j.1469-7793.2001.0099b.x

Cited by 101 publications

(48 citation statements)

References 76 publications

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“…Neural prostheses (NPs) that electrically activate central and peripheral systems have shown significant promise in supplementing function lost to disease or injury (Chapin, 2000;Prochazka et al, 2001;Stein and Mushahwar, 2005). Clinical advancements made possible by NP technology include those that restore hearing (Clark et al, 1977;Kessler, 1999;Spelman, 1999), respiration (DiMarco, 2001), bladder voiding (Brindley et al, 1982;Grill et al, 2001), and upper and lower extremity control (Kraft et al, 1992;Kralj et al, 1988;Liberson et al, 1961;Prochazka et al, 1997;Taylor et al, 1999;Weingarden et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

A lithographically-patterned, elastic multi-electrode array for surface stimulation of the spinal cord

Meacham

Giuly

Guo

et al. 2007

Biomed Microdevices

101

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A new, scalable process for microfabrication of a silicone-based, elastic multi-electrode array (MEA) is presented. The device is constructed by spinning poly(dimethylsiloxane) (PDMS) silicone elastomer onto a glass slide, depositing and patterning gold to construct wires and electrodes, spinning on a second PDMS layer, and then micropatterning the second PDMS layer to expose electrode contacts. The micropatterning of PDMS involves a custom reactive ion etch (RIE) process that preserves the underlying gold thin film. Once completed, the device can be removed from the glass slide for conformal interfacing with neural tissue. Prototype MEAs feature electrodes smaller than those known to be reported on silicone substrate (60 μm diameter exposed electrode area) and were capable of selectively stimulating the surface of the in vitro isolated spinal cord of the juvenile rat. Stretchable serpentine traces were also incorporated into the functional PDMS-based MEA, and their implementation and testing is described.

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Section: Introductionmentioning

confidence: 99%

A lithographically-patterned, elastic multi-electrode array for surface stimulation of the spinal cord

Meacham

Giuly

Guo

et al. 2007

Biomed Microdevices

101

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“…Most existing neuroprostheses stimulate peripheral nerves either through surface electrodes placed on the skin over nerves or through electrodes implanted blindly in close proximity to nerves [23]. However, the main disadvantage of these devices is their lack of specificity, leading to stimulation of unwanted areas in addition to target areas.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic implantation of neural electrodes on pelvic nerves: an experimental study on the obturator nerve in a chronic minipig model

et al. 2011

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“…Inferring meaningful conclusions from these data through appropriate processing and analyses impose a big challenge on the neuroscience and neuroengineering communities [28], [29]. To respond to this challenge sophisticated signal processing techniques are required to support the analyses.…”

Section: Tools For Neuronal Signal Analysismentioning

confidence: 99%

CyberRat Probes: High-Resolution Biohybrid Devices for Probing the Brain

Vassanelli

Felderer

Mahmud

et al. 2012

Biomimetic and Biohybrid Systems

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Abstract. Neuronal probes can be defined as biohybrid entities where the probes and nerve cells establish a close physical interaction for communicating in one or both directions. During the last decade neuronal probe technology has seen an exploded development. This paper presents newly developed chip-based CyberRat probes for enhanced signal transmission from nerve cells to chip or from chip to nerve cells with an emphasis on in−vivo interfacing, either in terms of signal−to−noise ratio or of spatiotemporal resolution. The oxide−insulated chips featuring large−scale and high−resolution arrays of stimulation and recording elements are a promising technology for high spatiotemporal resolution biohybrid devices, as recently demonstrated by recordings obtained from hippocampal slices and brain cortex in implanted animals. Finally, we report on SigMate, an in−house comprehensive automated tool for processing and analysis of acquired signals by such large scale biohybrid devices.

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Neural prostheses

Cited by 101 publications

References 76 publications

A lithographically-patterned, elastic multi-electrode array for surface stimulation of the spinal cord

A lithographically-patterned, elastic multi-electrode array for surface stimulation of the spinal cord

Laparoscopic implantation of neural electrodes on pelvic nerves: an experimental study on the obturator nerve in a chronic minipig model

CyberRat Probes: High-Resolution Biohybrid Devices for Probing the Brain

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