Neural recordings from a benzocyclobutene (BCB) based intra-cortical neural implant in an acute animal model

Clement, Ryan S.; Singh, Amritpal; Olson, B.; Lee, K.; He, Jiping

doi:10.1109/iembs.2003.1280172

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…A limited number of materials have undergone acute in vivo testing. For example, using BCB-based microelectrodes, Clement et al succeeded in recording neural signals from rat cortex [214]. Additionally, Altuna et al were able to record multi-unit activity as well as local field potentials (LFPs) using an SU-8 based microelectrode [215].…”

Section: Mechanically Compliant Intracortical Microelectrodesmentioning

confidence: 99%

Progress towards biocompatible intracortical microelectrodes for neural interfacing applications

et al. 2014

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To ensure long-term consistent neural recordings, next-generation intracortical microelectrodes are being developed with an increased emphasis on reducing the neuro-inflammatory response. The increased emphasis stems from the improved understanding of the multifaceted role that inflammation may play in disrupting both biologic and abiologic components of the overall neural interface circuit. To combat neuro-inflammation and improve recording quality, the field is actively progressing from traditional inorganic materials towards approaches that either minimizes the microelectrode footprint or that incorporate compliant materials, bioactive molecules, conducting polymers or nanomaterials. However, the immune-privileged cortical tissue introduces an added complexity compared to other biomedical applications that remains to be fully understood. This review provides a comprehensive reflection on the current understanding of the key failure modes that may impact intracortical microelectrode performance. In addition, a detailed overview of the current status of various materials-based approaches that have gained interest for neural interfacing applications is presented, and key challenges that remain to be overcome are discussed. Finally, we present our vision on the future directions of materials-based treatments to improve intracortical microelectrodes for neural interfacing.

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Section: Mechanically Compliant Intracortical Microelectrodesmentioning

confidence: 99%

Progress towards biocompatible intracortical microelectrodes for neural interfacing applications

et al. 2014

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“…Recently, we have shown the first successful fabrication [3] and neural recording capability of Benzocyclobutene (BCB) polymer based neural interface [4 ]. BCB is a new class of polymer developed by Dow under the trade name Cyclotene with unique properties that we believe is suitable for chronic implant application if proven long-term biocompatibility.…”

Section: Improving Mechanical Stiffness Of Coated Benzocyclobutene (Bmentioning

confidence: 99%

“…A craniotomy was performed, as described in our earlier paper [4], to access the targeted implant site over the rat's right barrel cortex (approximately 2 mm posterior and 5 mm lateral to bregma). All procedures were performed in compliance with the protocol for use of laboratory animals, which was reviewed and approved by the IACUC.…”

Section: Improving Mechanical Stiffness Of Coated Benzocyclobutene (Bmentioning

confidence: 99%

Improving mechanical stiffness of coated benzocyclobutene (BCB) based neural implant

Singh

Zhu

The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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We briefly report recent results of a simple alternate method to improve mechanical stiffness of BCB polymer neural implant for surgical insertion into brain tissue, which uses coatings dissolvable in bio-fluids. We have studied three different coating materials such as thermo-reversible gel Poloxamer 407, glucose (C6H12O6) and regular table sugar that were applied by dip coating onto the implant surface. The preliminary results of this study have shown that coating BCB probes with Poloxamer 407 polymer, a thermo-reversible gel, or table sugar significantly improves the buckling strength. However, the table sugar coating provides the greatest increase in stiffness, which is sufficient to penetrate both the preserved and live brain tissues without buckling.

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Let There Be Light—Optoprobes for Neural Implants

et al. 2017

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Neural recordings from a benzocyclobutene (BCB) based intra-cortical neural implant in an acute animal model

Cited by 3 publications

References 8 publications

Progress towards biocompatible intracortical microelectrodes for neural interfacing applications

Progress towards biocompatible intracortical microelectrodes for neural interfacing applications

Improving mechanical stiffness of coated benzocyclobutene (BCB) based neural implant

Let There Be Light—Optoprobes for Neural Implants

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