Neural Regulation of Innate Immunity in Inflammatory Skin Diseases

Huang, Xiaobao; Li, Fengxian; Wang, Fang

doi:10.3390/ph16020246

Cited by 6 publications

(3 citation statements)

References 120 publications

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“…This immune-neural regulation may exhibit abnormalities in individuals with AD and MDD, impairing the nervous system function(X. Huang, Li, & Wang, 2023).…”

Section: Discussionmentioning

confidence: 99%

The role of immune inflammatory response and inflammatory infiltrates in major depression disorder and atopic dermatitis: new insights from machine learning

Jiang,

Gong,

Yao

et al. 2023

Preprint

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Background: Major depression disorder (MDD) and atopic dermatitis (AD) are distinct disorders involving immune inflammatory responses. This study aimed to investigate the comorbid relationship between AD and MDD and to identify possible common mechanisms. Methods: We obtained AD and MDD data from the Gene Expression Omnibus (GEO) database. Differential expression analysis and the Genecard database were employed to identify shared genes associated with inflammatory diseases. These shared genes were then subjected to gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Hub genes were selected based on the protein-protein interactions using CytoHubba, and key regulatory genes were identified through enrichment analysis. Subsequently, we conducted immune infiltration and correlation analyses of the shared genes in AD. Finally, we employed three machine learning models to predict the significance of shared genes. Results: A total of 17 shared genes were identified in the AD_Inflammatory_MDD dataset (S100A9, PTGER2, PI3, SNCA, DAB2, PDGFA, FSTL1, CALD1, XK, UTS2, DHRS9, PARD3, NFIB, TMEM158, LIPH, RAB27B, and SH3BRL2). These genes were associated with biological processes such as the regulation of mesenchymal cell proliferation, mesenchymal cell proliferation, and glial cell differentiation. The neuroactive ligand-receptor interaction, IL-17 signaling, and Rap1 signaling pathways were significantly enriched in KEGG analysis. SNCA, S100A9, SH3BGRL2, RAB27B, TMEM158, DAB2, FSTL1, CALD1, and XK were identified as hub genes contributing to comorbid AD and MDD development. The three machine learning models consistently identified SNCA and PARD3 as important biomarkers. Conclusion: SNCA, S100A9, SH3BGRL2, RAB27B, TMEM158, DAB2, FSTL1, CALD1, and XK were identified as significant genes contributing to the development of AD and MDD comorbidities. Immune infiltration analysis showed a notable increase in the infiltration of various subtypes of CD4+ T cells, suggesting a potential association between the development of skin inflammation and the immune response. Across different machine learning models, SNCA and PARD3 consistently emerged as important biomarkers.

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“…This immune-neural regulation may exhibit abnormalities in individuals with AD and MDD, impairing the nervous system function(X. Huang, Li, & Wang, 2023).…”

Section: Discussionmentioning

confidence: 99%

The role of immune inflammatory response and inflammatory infiltrates in major depression disorder and atopic dermatitis: new insights from machine learning

Jiang,

Gong,

Yao

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…87 This novel concept is thus, changing our traditional understanding of skin barrier and immune functions. 88 Lately studies have been aimed at evaluation of NICUs as potential therapeutic targets in many inflammatory and autoimmune cutaneous diseases. Coupled with the knowledge of neuromediators synthesized, converted and metabolized in skin; many pharmacological models are now working on and testing the corresponding agonistic and antagonistic agents as possible treatment options.…”

Section: Neuronal Arm Of Cine Loop/cutaneous Peripheral Nervous Syste...mentioning

confidence: 99%

“…These NICUs encompass not only the local circuits but are also connected to regional and systemic neuronal and immune circuits for more specialized communication 87 . This novel concept is thus, changing our traditional understanding of skin barrier and immune functions 88 . Lately studies have been aimed at evaluation of NICUs as potential therapeutic targets in many inflammatory and autoimmune cutaneous diseases.…”

Section: Components Of Cine Interactomementioning

confidence: 99%

Cutaneous‐immuno‐neuro‐endocrine (CINE) system: A complex enterprise transforming skin into a super organ

Shastri,

Sharma,

Sharma

et al. 2024

Experimental Dermatology

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Skin is now emerging as a complex realm of three chief systems viz. immune system, nervous system, and endocrine system. The cells involved in their intricate crosstalk, namely native skin cells, intra‐cutaneous immune cells and cutaneous sensory neurons have diverse origin and distinct functions. However, recent studies have explored their role beyond their pre‐defined functional boundaries, such that the cells shun their traditional functions and adopt unconventional roles. For example, the native skin cells, apart from providing for basic structural framework of skin, also perform special immune functions and participate in extensive neuro‐endocrine circuitry, which were traditionally designated as functions of cutaneous resident immune cells and sensory neurons respectively. At the cellular level, this unique collaboration is brought out by special molecules called neuromediators including neurotransmitters, neuropeptides, neurotrophins, neurohormones and cytokines/chemokines. While this intricate crosstalk is essential for maintaining cutaneous homeostasis, its disruption is seen in various cutaneous diseases. Recent study models have led to a paradigm shift in our understanding of pathophysiology of many such disorders. In this review, we have described in detail the interaction of immune cells with neurons and native skin cells, role of neuromediators, the endocrine aspect in skin and current understanding of cutaneous neuro‐immuno‐endocrine loop in one of the commonest skin diseases, psoriasis. An accurate knowledge of this unique crosstalk can prove crucial in understanding the pathophysiology of different skin diseases and allow for generation of targeted therapeutic modalities.

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IL-17 family cytokines in inflammatory or autoimmune skin diseases

Kong,

Lai

2024

Advances in Immunology

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Neural Regulation of Innate Immunity in Inflammatory Skin Diseases

Cited by 6 publications

References 120 publications

The role of immune inflammatory response and inflammatory infiltrates in major depression disorder and atopic dermatitis: new insights from machine learning

The role of immune inflammatory response and inflammatory infiltrates in major depression disorder and atopic dermatitis: new insights from machine learning

Cutaneous‐immuno‐neuro‐endocrine (CINE) system: A complex enterprise transforming skin into a super organ

IL-17 family cytokines in inflammatory or autoimmune skin diseases

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