Neural responding during uncertain threat anticipation in pediatric anxiety

Michalska, Kalina J.; Benson, Brenda E.; Ivie, Elizabeth J.; Sachs, Jessica F.; Haller, Simone P.; Abend, Rany; McFarlin, Daniel R.; Blackford, Jennifer Urbano; Pine, Daniel S.

doi:10.1016/j.ijpsycho.2022.07.006

Cited by 10 publications

(4 citation statements)

References 81 publications

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“…In addition, at the whole-brain level, individuals with higher anxiety showed lower activation of the vlPFC to the safety compound than to the novel compound during early trials of the task (although this difference was not observed during later trials of the task). Given the involvement of the vlPFC in processes that include cognitive control, implicit emotion regulation, and affect labeling ( 43 , 44 , 45 , 46 , 47 ), this difference may be consistent with weaker regulation in the affective domain that has been shown in previous work on anxiety ( 48 , 49 , 50 , 51 , 52 ). We did not observe differences in recruitment of the vlPFC later in the task, which could suggest either that this region was no longer recruited across participants or that there was no longer a relationship to anxiety during the later trials.…”

Section: Discussionsupporting

confidence: 72%

Hippocampal Involvement in Safety Signal Learning Varies With Anxiety Among Healthy Adults

Odriozola¹,

Kribakaran²,

Cohodes³

et al. 2024

Biological Psychiatry Global Open Science

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Section: Discussionsupporting

confidence: 72%

Hippocampal Involvement in Safety Signal Learning Varies With Anxiety Among Healthy Adults

Odriozola¹,

Kribakaran²,

Cohodes³

et al. 2024

Biological Psychiatry Global Open Science

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“…The IPL is involved in deliberate and sustained attention [ 122 , 123 ], but elevated IPL activity during threat processing may also indicate hypervigilance [ 124 ]. Children with anxiety display hypervigilance to threats [ 1 , 3 , 15 , 125 – 129 ] and right IPL hyperactivity during emotion processing [ 130 ]. Additionally, among anxious and non-anxious youth, negative affect is associated with left IPL-amygdala functional connectivity when appraising threat [ 131 ].…”

Section: Discussionmentioning

confidence: 99%

Pre-scan state anxiety is associated with greater right amygdala-hippocampal response to fearful versus happy faces among trait-anxious Latina girls

Díaz,

Tseng,

Michalska

2024

BMC Psychiatry

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Background Unfamiliarity with academic research may contribute to higher levels of anticipatory state anxiety about affective neuroimaging tasks. Children with high trait anxiety display differences in brain response to fearful facial affect compared to non-anxious youth, but little is known about the influence of state anxiety on this association. Because reduced engagement in scientific research and greater mistrust among minoritized groups may lead to systematic differences in pre-scan state anxiety, it is crucial to understand the neural correlates of state anxiety during emotion processing so as to disambiguate sources of individual differences. Methods The present study probed the interactive effects of pre-scan state anxiety, trait anxiety, and emotional valence (fearful vs. happy faces) on neural activation during implicit emotion processing in a community sample of 46 preadolescent Latina girls (8–13 years). Results Among girls with mean and high levels of trait anxiety, pre-scan state anxiety was associated with greater right amygdala-hippocampal and left inferior parietal lobe response to fearful faces relative to happy faces. Conclusions Anticipatory state anxiety in the scanning context may cause children with moderate and high trait anxiety to be hypervigilant to threats, further compounding the effects of trait anxiety. Neuroimaging researchers should control for state anxiety so that systematic differences in brain activation resulting from MRI apprehension are not misleadingly attributed to demographic or environmental characteristics.

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“…Five articles in the special issue focused on examining the role of intolerance of uncertainty (or putative markers of intolerance of uncertainty) on neural and psychophysiological responses (fMRI, ERPs, skin Running Head: Editorial for SI conductance response, and startle potentiation (eye-blink reflex). Michalska et al, (2022) used parametric manipulation of threat probability during fMRI in youth with and without anxiety disorders. The findings revealed that youth with anxiety disorders-compared with controls-exhibited greater activation in the ventrolateral prefrontal cortex in response to uncertain threat as well as altered scaling of ventral striatum-subgenual anterior cingulate cortex activation with threat probability.…”

Section: Developmental and Clinical Populationsmentioning

confidence: 99%