Neural Responses to Facial Expressions of Disgust but not Fear are Modulated by Washing Symptoms in OCD

Get Aroused and Be Stronger: Emotional Facilitation of Physical Effort in the Human Brain

“…Indeed, the VLPFC, often accompanied by the amygdala and insula, was recently shown to be activated in relation to the intensity of IAPS pictures, anticipation of negative pictures, negative facial expressions, affect naming, emotional distraction, reappraisal and regulation, and experienced or self-induced sadness and happiness Pelletier et al, 2003;Habel et al, 2005;Dolcos and McCarthy, 2006;Drabant et al, 2006;Grimm et al, 2006;Lieberman et al, 2007;Mataix-Cols et al, 2008;Onoda et al, 2008;Wager et al, 2008). Abnormal activity in the same regions during emotional processing has been reported in a variety of psychiatric conditions involving emotional dysfunction such as mania, depression, negative psychotic symptoms, stress, anxiety, and obsessive compulsive disorders (Fahim et al, 2005;Monk et al, 2006;Taylor et al, 2006;Johnstone et al, 2007;Lawrence et al, 2007;Pavuluri et al, 2007;Foland et al, 2008;Guyer et al, 2008).…”

Integrating Diffusion Tensor Imaging-Based Tractography into Deep Brain Stimulation Surgery: A Review of the Literature

“…Studies comparing patients with neurological and psychiatric diseases and healthy volunteers using PET and fMRI have shown hyper- or hypoactivity in specific functional pathways and functional normalizations of these areas with pharmacological and nonpharmacological treatment options [62,63,64,65,66]. Although this approach might oversimplify the neurobiological interplay between structural and functional conditions, these findings have served as a rationale for the successful application of DBS in these areas for certain disorders [29,39].…”

OCD: obsessive–compulsive … disgust? The role of

“…Functional MRI studies of disgust facial perception have often reported activation of the caudate and putamen, in addition to the insula. 50,51 Increases in basal ganglia activity have been reported in fMRI studies using disgustinducing photographs, 51,54 facial expressions of disgust 55,56 and in fMRI studies that encouraged participants to recall events that evoked feelings of disgust. 57 The importance of the basal gan glia in the recognition of disgust was also demonstrated in a study in which carriers and patients with Huntington dis ease, a disorder involving the striatum, displayed impair ments in facial recognition of disgust, but not other emo tions.…”