Neural Signaling Metabolites May Modulate Energy Use in Hibernation

Drew, Kelly L.; Frare, Carla; Rice, Sarah A

doi:10.1007/s11064-016-2109-4

Cited by 10 publications

(4 citation statements)

References 112 publications

(148 reference statements)

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“…In the laboratory, after transfer from summer-like conditions [LD photoperiod and warm ambient temperature (LD-Warm)] to winter-like conditions [SD photoperiod and cold ambient temperature (SD-Cold)], most Syrian hamsters require a long pre-HIB (typically 2–3 months) before initiating hibernation (Figure 1A) (Jansky et al, 1984; Chayama et al, 2016). This requirement of a long induction period in SD-Cold implies that the pre-hibernation remodeling process, involving changes in the thermoregulatory system and the regulation of body mass, is present in Syrian hamsters, as in strictly seasonal hibernators (Arnold et al, 2011; Olson et al, 2013; Sheriff et al, 2013; Drew et al, 2017). In fact, during the pre-HIB, the female Syrian hamsters underwent physiological body remodeling; they gradually reduce their body mass and the set-point of core body temperature (Arai et al, 2005; Chayama et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Molecular Basis of White Adipose Tissue Remodeling That Precedes and Coincides With Hibernation in the Syrian Hamster, a Food-Storing Hibernator

et al. 2019

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Mammalian hibernators store fat extensively in white adipose tissues (WATs) during pre-hibernation period (Pre-HIB) to prepare for hibernation. However, the molecular mechanisms underlying the pre-hibernation remodeling of WAT have not been fully elucidated. Syrian hamsters, a food-storing hibernator, can hibernate when exposed to a winter-like short day photoperiod and cold ambient temperature (SD-Cold). Animals subjected to prolonged SD-Cold had smaller white adipocytes and beige-like cells within subcutaneous inguinal WAT (iWAT). Time-course analysis of gene expression with RNA-sequencing and quantitative PCR demonstrated that the mRNA expression of not only genes involved in lipid catabolism (lipolysis and beta-oxidation) but also lipid anabolism (lipogenesis and lipid desaturation) was simultaneously up-regulated prior to hibernation onset in the animals. The enhanced capacity of both lipid catabolism and lipid anabolism during hibernation period (HIB) is striking contrast to previous observations in fat-storing hibernators that only enhance catabolism during HIB. The mRNA expression of mTORC1 and PPAR signaling molecules increased, and pharmacological activation of PPARs indeed up-regulated lipid metabolism genes in iWAT explants from Syrian hamsters. These results suggest that the Syrian hamster rewires lipid metabolisms while preparing for hibernation to effectively utilize body fat and synthesize it from food intake during HIB.

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Section: Introductionmentioning

confidence: 99%

Molecular Basis of White Adipose Tissue Remodeling That Precedes and Coincides With Hibernation in the Syrian Hamster, a Food-Storing Hibernator

et al. 2019

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“…TRH receptor density decreases in torpor compared with euthermia in the PVN and in the medial preoptic area of the POA, both thermoregulatory regions (Stanton et al, ). As TRH is linked to metabolic state, we can speculate that a metabolic clue may trigger thermogenesis, however the signaling mechanisms initiating rewarming are still unknown (Drew et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Adenosine is a well‐known endogenous sleep promoting neurotransmitter (Bjorness and Greene, ) and the role of the A 1 AR in hibernation and torpor has been shown in AGS, hamsters and mice (Drew et al, ). We identify the TMN, within the sleep–wake pathway as the major nuclei mediating the somnogenic effect of CHA.…”

Section: Discussionmentioning

confidence: 99%

Seasonal decrease in thermogenesis and increase in vasoconstriction explain seasonal response to N⁶‐cyclohexyladenosine‐induced hibernation in the Arctic ground squirrel (Urocitellus parryii)

Frare

Jenkins

McClure

et al. 2019

Journal of Neurochemistry

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Hibernation is a seasonal phenomenon characterized by a drop in metabolic rate and body temperature. Adenosine A1 receptor agonists promote hibernation in different mammalian species, and the understanding of the mechanism inducing hibernation will inform clinical strategies to manipulate metabolic demand that are fundamental to conditions such as obesity, metabolic syndrome, and therapeutic hypothermia. Adenosine A1 receptor agonist‐induced hibernation in Arctic ground squirrels is regulated by an endogenous circannual (seasonal) rhythm. This study aims to identify the neuronal mechanism underlying the seasonal difference in response to the adenosine A1 receptor agonist. Arctic ground squirrels were implanted with body temperature transmitters and housed at constant ambient temperature (2°C) and light cycle (4L:20D). We administered CHA (N6‐cyclohexyladenosine), an adenosine A1 receptor agonist in euthermic‐summer phenotype and euthermic‐winter phenotype and used cFos and phenotypic immunoreactivity to identify cell groups affected by season and treatment. We observed lower core and subcutaneous temperature in winter animals and CHA produced a hibernation‐like response in winter, but not in summer. cFos‐ir was greater in the median preoptic nucleus and the raphe pallidus in summer after CHA. CHA administration also resulted in enhanced cFos‐ir in the nucleus tractus solitarius and decreased cFos‐ir in the tuberomammillary nucleus in both seasons. In winter, cFos‐ir was greater in the supraoptic nucleus and lower in the raphe pallidus than in summer. The seasonal decrease in the thermogenic response to CHA and the seasonal increase in vasoconstriction, assessed by subcutaneous temperature, reflect the endogenous seasonal modulation of the thermoregulatory systems necessary for CHA‐induced hibernation. Cover Image for this issue: doi: .

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“…Seasonal changes in brain adenosine levels may contribute to an increase in A1R sensitivity leading to the onset of hibernation (Frare and Drew, 2021). Although the mechanisms controlling hibernation are currently unclear, activation of A 1 Rs signaling in the CNS appears to be required for the onset of this phenomenon, as activation of the A 1 Rs in the CNS can induce hibernation or some hibernation-like states in obligate, facultative, or non-hibernating animals (Drew et al, 2017;Shimaoka et al, 2018;Frare and Drew, 2021). In addition, Shimaoka et al (2018) activated central A 1 Rs in rats, a nonhibernating animal, which induced a hypothermia response similar to hibernation.…”

Section: Central Activation Of a 1 Rs Is Sufficient To Induce And Mai...mentioning

confidence: 99%

Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation

Yuan

Zhang

et al. 2023

Front. Pharmacol.

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Graphical AbstractAdenosine mediates sleep, torpor and hibernation through P1 receptors. Recent reasearch has shown that P1 receptors play a vital role in the regulation of sleep-wake, torpor and hibernation-like states. In this review, we focus on the roles and neurobiological mechanisms of the CNS adenosine and P1 receptors in these three states. Among them, A1 and A2A receptors are key targets for sleep-wake regulation, A1Rs and A3Rs are very important for torpor induction, and activation of A1Rs is sufficient for hibernation-like state.

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Neural Signaling Metabolites May Modulate Energy Use in Hibernation

Cited by 10 publications

References 112 publications

Molecular Basis of White Adipose Tissue Remodeling That Precedes and Coincides With Hibernation in the Syrian Hamster, a Food-Storing Hibernator

Molecular Basis of White Adipose Tissue Remodeling That Precedes and Coincides With Hibernation in the Syrian Hamster, a Food-Storing Hibernator

Seasonal decrease in thermogenesis and increase in vasoconstriction explain seasonal response to N⁶‐cyclohexyladenosine‐induced hibernation in the Arctic ground squirrel (Urocitellus parryii)

Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation

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Neural Signaling Metabolites May Modulate Energy Use in Hibernation

Cited by 10 publications

References 112 publications

Molecular Basis of White Adipose Tissue Remodeling That Precedes and Coincides With Hibernation in the Syrian Hamster, a Food-Storing Hibernator

Molecular Basis of White Adipose Tissue Remodeling That Precedes and Coincides With Hibernation in the Syrian Hamster, a Food-Storing Hibernator

Seasonal decrease in thermogenesis and increase in vasoconstriction explain seasonal response to N6‐cyclohexyladenosine‐induced hibernation in the Arctic ground squirrel (Urocitellus parryii)

Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation

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Seasonal decrease in thermogenesis and increase in vasoconstriction explain seasonal response to N⁶‐cyclohexyladenosine‐induced hibernation in the Arctic ground squirrel (Urocitellus parryii)