Neural signature of attention impairment in allergic asthma: an ERP study

Gholami-Mahtaj, Leila; Mooziri, Morteza; Bamdad, Sobhan; Mikaili, Mohammad; Jamaati, Hamidreza; Raoufy, Mohammad Reza

doi:10.1080/00207454.2022.2151908

Cited by 4 publications

(2 citation statements)

References 40 publications

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“…While the exact mechanisms by which asthma influences the central nervous system (CNS) and vice versa are not known, there is evidence that chronic inflammatory conditions can lead to a disruption in the homeostasis of the neuroimmune environment ( Konstantinou et al, 2022 ). Potential mechanisms associated with asthma and ADHD ( Tsai et al, 2014 ; van der Schans et al, 2016 ; Chang et al, 2022 ; Gholami-Mahtaj et al, 2022 ; Jin et al, 2022 ) are possibly related to the effects of chronic allergic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Omalizumab in combination with subcutaneous immunotherapy for the treatment of multiple allergies associated with attention-deficit/hyperactivity disorder: a case report and a literature review

Ding,

2024

Front. Pharmacol.

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We describe the case of a 10-year-old boy with asthma (AS), accompanied by allergic rhinitis (AR), food allergy (FA), and combined attention-deficit/hyperactivity disorder (ADHD), who was treated at Shanghai Renji Hospital on 11 July 2020. The efficiency of the previous treatment with salmeterol/ticlosone was poor. Treatment with montelukast sodium resulted in development of neurological symptoms. Treatment with omalizumab in combination with subcutaneous immunotherapy (SCIT) was then initiated in our department based on anti-asthmatic therapy. Symptoms of asthma were completely controlled, and FA and AR symptoms improved. The treatment regimen led to a significant improvement in ADHD symptoms and the overall quality of life of the patient. The literature search was done in the PubMed database using “attention deficit/hyperactivity disorder/ADHD” and “asthma” as keywords, and we identified 47 relevant articles. In conclusion, our results show that treating asthma with omalizumab in combination with salmeterol/ticlosone and SCIT is efficient in controlling symptoms of multiple allergies and may lead to the improvement in ADHD symptoms and the overall quality of life of pediatric patients with ADHD. While current studies suggest that allergic diseases are closely related to ADHD, there is still a lack of studies or case reports of complete treatment protocols to provide clinical clues for management of the disease.

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Section: Discussionmentioning

confidence: 99%

Omalizumab in combination with subcutaneous immunotherapy for the treatment of multiple allergies associated with attention-deficit/hyperactivity disorder: a case report and a literature review

Ding,

2024

Front. Pharmacol.

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“…In this line, it is shown that OB local activity is elevated in animals during fear 10 , 12 . Furthermore, human and animal studies show that allergic respiratory diseases, such as allergic rhinitis, are associated with cognitive and psychiatric abnormalities as well as disrupted brain activity 2 , 6 , 8 , 14 , 15 , 19 – 21 , which are suggested to be mediated by changes in OB function due to olfactory sensory neurons (OSNs) dysfunction 10 , 22 – 24 . Furthermore, OB activity is believed to be strongly entrained by respiration, a phenomenon which might have substantial contributions to different behaviors 10 , 12 , 18 .…”

Section: Introductionmentioning

confidence: 99%

Olfactory bulb-medial prefrontal cortex theta synchronization is associated with anxiety

Mooziri,

Samii Moghaddam,

Mirshekar

et al. 2024

Sci Rep

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Anxiety is among the most fundamental mammalian behaviors. Despite the physiological and pathological importance, its underlying neural mechanisms remain poorly understood. Here, we recorded the activity of olfactory bulb (OB) and medial prefrontal cortex (mPFC) of rats, which are critical structures to brain’s emotional processing network, while exploring different anxiogenic environments. Our results show that presence in anxiogenic contexts increases the OB and mPFC regional theta activities. Also, these local activity changes are associated with enhanced OB-mPFC theta power- and phase-based functional connectivity as well as OB-to-mPFC information transfer. Interestingly, these effects are more prominent in the unsafe zones of the anxiogenic environments, compared to safer zones. This consistent trend of changes in diverse behavioral environments as well as local and long-range neural activity features suggest that the dynamics of OB-mPFC circuit theta oscillations might underlie different types of anxiety behaviors, with possible implications for anxiety disorders.

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Neuroimmune pathways regulating airway inflammation

Trevizan‐Baú

Mazzone

2023

Annals of Allergy, Asthma & Immunology

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Neural signature of attention impairment in allergic asthma: an ERP study

Cited by 4 publications

References 40 publications

Omalizumab in combination with subcutaneous immunotherapy for the treatment of multiple allergies associated with attention-deficit/hyperactivity disorder: a case report and a literature review

Omalizumab in combination with subcutaneous immunotherapy for the treatment of multiple allergies associated with attention-deficit/hyperactivity disorder: a case report and a literature review

Olfactory bulb-medial prefrontal cortex theta synchronization is associated with anxiety

Neuroimmune pathways regulating airway inflammation

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