Neural signature of behavioural inhibition in women with bulimia nervosa

Skunde, Mandy; Walther, Stephan; Simon, Joe J.; Wu, Mei‐Mei; Bendszus, Martin; Herzog, Wolfgang; Friederich, Hans‐Christoph

doi:10.1503/jpn.150335

Cited by 58 publications

(62 citation statements)

References 54 publications

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“…In keeping with this notion, research has found that impaired inhibitory control is positively associated with a poorer treatment outcome for overweight children [132,133]. It is thought that this inefficient self-regulatory system might be due to abnormal brain activation in the fronto-striatal networks [134][135][136][137]. Consequently, difficulties in inhibitory control may be one mechanism that helps to explain why people with obesity and binge eating develop eating behaviours that can become highly persistent and difficult to change.…”

Section: Control Over Eating Behaviour: Impulsive and Compulsive Traitsmentioning

confidence: 97%

Emotional Eating, Binge Eating and Animal Models of Binge-Type Eating Disorders

2017

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Evidence has been found to suggest that for some high-risk individuals, obesity/binge eating may develop as an impulsive reaction to negative emotions that over time becomes a compulsive habit. Animal models highlight the neural mechanisms that might underlie this process and suggest similarities with substance use disorders. Emotional difficulties and neurobiological factors have a role in the aetiology of eating and weight disorders. Precise treatments targeted at these mechanisms may be of help for people who have difficulties with compulsive overeating.

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Section: Control Over Eating Behaviour: Impulsive and Compulsive Traitsmentioning

confidence: 97%

Emotional Eating, Binge Eating and Animal Models of Binge-Type Eating Disorders

2017

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“…On task-based fMRI, BN patients display low frontostriatal activity on a number of cognitive control tasks, including the Simon Spatial task (Marsh et al, 2009b, 2011) and Go/No-Go (Skunde et al, 2016). Similarly, AN patients have also been shown to have altered frontostriatal activation on executive function tasks, including the Wisconsin Card Sorting Task (Lao-Kaim et al, 2015), and delay discounting (Wierenga et al, 2014; Decker et al, 2015).…”

Section: Abnormalities Of Sn-cstc Loop Circuits In Psychiatric Illnessesmentioning

confidence: 99%

Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment

Peters

Dunlop

Downar³

2016

Front. Syst. Neurosci.

462

298

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The salience network (SN) plays a central role in cognitive control by integrating sensory input to guide attention, attend to motivationally salient stimuli and recruit appropriate functional brain-behavior networks to modulate behavior. Mounting evidence suggests that disturbances in SN function underlie abnormalities in cognitive control and may be a common etiology underlying many psychiatric disorders. Such functional and anatomical abnormalities have been recently apparent in studies and meta-analyses of psychiatric illness using functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM). Of particular importance, abnormal structure and function in major cortical nodes of the SN, the dorsal anterior cingulate cortex (dACC) and anterior insula (AI), have been observed as a common neurobiological substrate across a broad spectrum of psychiatric disorders. In addition to cortical nodes of the SN, the network’s associated subcortical structures, including the dorsal striatum, mediodorsal thalamus and dopaminergic brainstem nuclei, comprise a discrete regulatory loop circuit. The SN’s cortico-striato-thalamo-cortical loop increasingly appears to be central to mechanisms of cognitive control, as well as to a broad spectrum of psychiatric illnesses and their available treatments. Functional imbalances within the SN loop appear to impair cognitive control, and specifically may impair self-regulation of cognition, behavior and emotion, thereby leading to symptoms of psychiatric illness. Furthermore, treating such psychiatric illnesses using invasive or non-invasive brain stimulation techniques appears to modulate SN cortical-subcortical loop integrity, and these effects may be central to the therapeutic mechanisms of brain stimulation treatments in many psychiatric illnesses. Here, we review clinical and experimental evidence for abnormalities in SN cortico-striatal-thalamic loop circuits in major depression, substance use disorders (SUD), anxiety disorders, schizophrenia and eating disorders (ED). We also review emergent therapeutic evidence that novel invasive and non-invasive brain stimulation treatments may exert therapeutic effects by normalizing abnormalities in the SN loop, thereby restoring the capacity for cognitive control. Finally, we consider a series of promising directions for future investigations on the role of SN cortico-striatal-thalamic loop circuits in the pathophysiology and treatment of psychiatric disorders.

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“…Only two published studies of binge-eating populations have used neuroimaging in combination with go/no-go tasks that included both food-specific and neutral stimuli [118,119]. In one task, one block included high-calorie food images as go stimuli and toy images as no-go stimuli, and in the other block this was reversed [118].…”

Section: Self-regulatory Controlmentioning

confidence: 99%

“…The task was used with concurrent magnetoencephalography (MEG) to determine the specific nature of inhibitory control deficits in individuals with BED relative to weight-matched controls [118]. The second task was used with fMRI to compare women with BN to controls [119] and was a variant of a paradigm that had been previously adapted to study substance-use specific inhibition in alcohol use disorders [35]. This task included only neutral shapes as go and no-go stimuli, or neutral object images as go stimuli and food images as no-go stimuli [119].…”

Section: Self-regulatory Controlmentioning

confidence: 99%

“…The second task was used with fMRI to compare women with BN to controls [119] and was a variant of a paradigm that had been previously adapted to study substance-use specific inhibition in alcohol use disorders [35]. This task included only neutral shapes as go and no-go stimuli, or neutral object images as go stimuli and food images as no-go stimuli [119]. Thus, these tasks used different combinations of image types paired differently with go or no-go instructions.…”

Section: Self-regulatory Controlmentioning

confidence: 99%

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Behind binge eating: A review of food-specific adaptations of neurocognitive and neuroimaging tasks

Berner

Winter

Matheson

et al. 2017

Physiology & Behavior

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Recurrent binge eating, or overeating accompanied by a sense of loss of control, is a major public health concern. Identifying similarities and differences among individuals with binge eating and those with other psychiatric symptoms and characterizing the deficits that uniquely predispose individuals to eating problems are essential to improving treatment. Research suggests that altered reward and control-related processes may contribute to dysregulated eating and other impulsive behaviors in binge-eating populations, but the best methods for reliably assessing the contributions of these processes to binge eating are unclear. In this review, we summarize standard neurocognitive and neuroimaging tasks that assess reward and control-related processes, describe adaptations of these tasks used to study eating and food-specific responsivity and deficits, and consider the advantages and limitations of these tasks. Future studies integrating both general and food-specific tasks with neuroimaging will improve understanding of the neurocognitive processes and neural circuits that contribute to binge eating and could inform novel interventions that more directly target or prevent this transdiagnostic behavior.

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Neural signature of behavioural inhibition in women with bulimia nervosa

Cited by 58 publications

References 54 publications

Emotional Eating, Binge Eating and Animal Models of Binge-Type Eating Disorders

Emotional Eating, Binge Eating and Animal Models of Binge-Type Eating Disorders

Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment

Behind binge eating: A review of food-specific adaptations of neurocognitive and neuroimaging tasks

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