Neural stem cell metabolism revisited: a critical role for mitochondria

Complex II ambiguities—FADH2 in the electron transfer system

“…As a consequence, the prosthetic group FADH 2 appears erroneously as the substrate of CII in the ETS linked to succinate oxidation. This error is widely propagated in publications found from 2001 to 2023 ( 4 , 23 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 …”

Systemic phospho-defective and phospho-mimetic Drp1 mice exhibit normal growth and development with altered anxiety-like behavior

“…During embryonic development, neuronal stem cells are mitotic and actively proliferate to support brain growth. 57 , 58 , 59 The mitosis of neuronal stem cells is important for the proper regulation of cell fate determination in the developing brain. 58 , 59 , 60 At the same time, neuronal stem cells differentiate into specific types of neurons and glial cells in neurogenesis.…”

“… 57 , 58 , 59 The mitosis of neuronal stem cells is important for the proper regulation of cell fate determination in the developing brain. 58 , 59 , 60 At the same time, neuronal stem cells differentiate into specific types of neurons and glial cells in neurogenesis. 57 , 58 , 59 It is possible that the mitotic regulation of mitochondrial division is crucial in such neuronal stem cells for proper neurogenesis and thereby establishing neural circuits.…”

“… 58 , 59 , 60 At the same time, neuronal stem cells differentiate into specific types of neurons and glial cells in neurogenesis. 57 , 58 , 59 It is possible that the mitotic regulation of mitochondrial division is crucial in such neuronal stem cells for proper neurogenesis and thereby establishing neural circuits. In addition to mitotic regulation, mitochondrial division and fusion are important for cell fate determination in neurogenesis in post-mitotic neuronal stem cells.…”

“…In addition to mitotic regulation, mitochondrial division and fusion are important for cell fate determination in neurogenesis in post-mitotic neuronal stem cells. 59 , 61 We hypothesize that Drp1 phosphorylation regulates mitochondrial division during the mitosis of neural stem cells for brain development, and/or in post-mitotic neural stem cells for neurogenesis. We envision that a delicate balance between mitochondrial division and fusion plays critical roles in both processes, and alterations in these processes lead to altered animal behaviors, observed as changes in anxiety behaviors.…”