Neural Substrate to Associate Odorants and Pheromones: Convergence of Projections from the Main and Accessory Olfactory Bulbs in Mice

Cádiz-Moretti, Bernardita; Martı́nez-Garcı́a, Fernando; Lanuza, Enrique

doi:10.1007/978-1-4614-5927-9_1

Cited by 15 publications

(22 citation statements)

References 23 publications

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“…Our results confirm that the CxA receives convergent projections arising from the main and accessory olfactory bulbs ( Figure 8A ), corroborating previous works done with anterograde and retrograde tracers (Pro-Sistiaga et al, 2007; Kang et al, 2009; Cádiz-Moretti et al, 2013). The MOB is the main sensory input to the CxA, sending much stronger projections than the AOB, which sends only minor projections.…”

Section: Discussionsupporting

confidence: 92%

“…The superficial injections (mainly centered in layer I) displayed more labeling in the AOB than injections centered in layer II. The AOB fibers that project to CxA mainly innervate layer I, with only some fibers coursing inward to innervate deep layers (in rat, Pro-Sistiaga et al, 2007; in mouse, Cádiz-Moretti et al, 2013). The fibers in layer I were described as thick and varicose, suggesting that they may form en passant synapses in the distal portions of the dendrites of the CxA neurons (Pro-Sistiaga et al, 2007; Cádiz-Moretti et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…The AOB fibers that project to CxA mainly innervate layer I, with only some fibers coursing inward to innervate deep layers (in rat, Pro-Sistiaga et al, 2007; in mouse, Cádiz-Moretti et al, 2013). The fibers in layer I were described as thick and varicose, suggesting that they may form en passant synapses in the distal portions of the dendrites of the CxA neurons (Pro-Sistiaga et al, 2007; Cádiz-Moretti et al, 2013). Therefore, the differences in the observed retrograde labeling in the AOB could be explained by the uptake of the tracer by these fibers in the superficial injections, and consequently we consider unlikely the possibility of the uptake of the tracer by fibers damaged in the lo by the micropipette tip.…”

Section: Discussionmentioning

confidence: 99%

“…From the hodological point of view, the CxA also differs from the adjacent Pir in the reception of a small projection from the AOB, both in rats (Pro-Sistiaga et al, 2007) and mice (Cádiz-Moretti et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

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Afferent and Efferent Connections of the Cortex-Amygdala Transition Zone in Mice

et al. 2016

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The transitional zone between the ventral part of the piriform cortex and the anterior cortical nucleus of the amygdala, named the cortex-amygdala transition zone (CxA), shows two differential features that allow its identification as a particular structure. First, it receives dense cholinergic and dopaminergic innervations as compared to the adjacent piriform cortex and amygdala, and second, it receives projections from the main and accessory olfactory bulbs. In this work we have studied the pattern of afferent and efferent projections of the CxA, which are mainly unknown, by using the retrograde tracer Fluorogold and the anterograde tracer biotinylated dextranamine. The results show that the CxA receives a relatively restricted set of intratelencephalic connections, originated mainly by the olfactory system and basal forebrain, with minor afferents from the amygdala. The only relevant extratelencephalic afference originates in the ventral tegmental area (VTA). The efferent projections of the CxA reciprocate the inputs from the piriform cortex and olfactory amygdala. In addition, the CxA projects densely to the basolateral amygdaloid nucleus and the olfactory tubercle. The extratelencephalic projections of the CxA are very scarce, and target mainly hypothalamic structures. The pattern of connections of the CxA suggests that it is indeed a transitional area between the piriform cortex and the cortical amygdala. Double labeling with choline acetyltransferase indicates that the afferent projection from the basal forebrain is the origin of its distinctive cholinergic innervation, and double labeling with dopamine transporter shows that the projection from the VTA is the source of dopaminergic innervation. These connectivity and neurochemical features, together with the fact that it receives vomeronasal in addition to olfactory information, suggest that the CxA may be involved in processing olfactory information endowed with relevant biological meaning, such as odors related to reproductive or defensive behaviors.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Afferent and Efferent Connections of the Cortex-Amygdala Transition Zone in Mice

et al. 2016

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“…Only the MeA gives rise to significant projections to the anterior Pir, particularly around the lo, where they may converge with a light innervation directly originated by the mitral cells of the AOB (Cadiz-Moretti et al, in press). Therefore, as suggested previously (see Martínez-García et al, 2012), the Pir should not be viewed as a primary olfactory cortex, but as an associative chemosensory cortex.…”

Section: Discussionmentioning

confidence: 99%

Differential efferent projections of the anterior, posteroventral, and posterodorsal subdivisions of the medial amygdala in mice

Pardo-Bellver¹,

Cádiz-Moretti²,

Novejarque³

et al. 2012

Front. Neuroanat.

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The medial amygdaloid nucleus (Me) is a key structure in the control of sociosexual behavior in mice. It receives direct projections from the main and accessory olfactory bulbs (AOB), as well as an important hormonal input. To better understand its behavioral role, in this work we investigate the structures receiving information from the Me, by analysing the efferent projections from its anterior (MeA), posterodorsal (MePD) and posteroventral (MePV) subdivisions, using anterograde neuronal tracing with biotinylated and tetrametylrhodamine-conjugated dextranamines. The Me is strongly interconnected with the rest of the chemosensory amygdala, but shows only moderate projections to the central nucleus and light projections to the associative nuclei of the basolateral amygdaloid complex. In addition, the MeA originates a strong feedback projection to the deep mitral cell layer of the AOB, whereas the MePV projects to its granule cell layer. The Me (especially the MeA) has also moderate projections to different olfactory structures, including the piriform cortex (Pir). The densest outputs of the Me target the bed nucleus of the stria terminalis (BST) and the hypothalamus. The MeA and MePV project to key structures of the circuit involved in the defensive response against predators (medial posterointermediate BST, anterior hypothalamic area, dorsomedial aspect of the ventromedial hypothalamic nucleus), although less dense projections also innervate reproductive-related nuclei. In contrast, the MePD projects mainly to structures that control reproductive behaviors [medial posteromedial BST, medial preoptic nucleus, and ventrolateral aspect of the ventromedial hypothalamic nucleus], although less dense projections to defensive-related nuclei also exist. These results confirm and extend previous results in other rodents and suggest that the medial amygdala is anatomically and functionally compartmentalized.

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Afferent and efferent projections of the anterior cortical amygdaloid nucleus in the mouse

Cádiz-Moretti

Abellán-Álvaro

Pardo-Bellver

et al. 2017

J of Comparative Neurology

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The anterior cortical amygdaloid nucleus (ACo) is a chemosensory area of the cortical amygdala that receives afferent projections from both the main and accessory olfactory bulbs. The role of this structure is unknown, partially due to a lack of knowledge of its connectivity. In this work, we describe the pattern of afferent and efferent projections of the ACo by using fluorogold and biotinylated dextranamines as retrograde and anterograde tracers, respectively. The results show that the ACo is reciprocally connected with the olfactory system and basal forebrain, as well as with the chemosensory and basomedial amygdala. In addition, it receives dense projections from the midline and posterior intralaminar thalamus, and moderate projections from the posterior bed nucleus of the stria terminalis, mesocortical structures and the hippocampal formation. Remarkably, the ACo projects moderately to the central nuclei of the amygdala and anterior bed nucleus of the stria terminalis, and densely to the lateral hypothalamus. Finally, minor connections are present with some midbrain and brainstem structures. The afferent projections of the ACo indicate that this nucleus might play a role in emotional learning involving chemosensory stimuli, such as olfactory fear conditioning. The efferent projections confirm this view and, given its direct output to the medial part of the central amygdala and the hypothalamic 'aggression area', suggest that the ACo can initiate defensive and aggressive responses elicited by olfactory or, to a lesser extent, vomeronasal stimuli.

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Neural Substrate to Associate Odorants and Pheromones: Convergence of Projections from the Main and Accessory Olfactory Bulbs in Mice

Cited by 15 publications

References 23 publications

Afferent and Efferent Connections of the Cortex-Amygdala Transition Zone in Mice

Afferent and Efferent Connections of the Cortex-Amygdala Transition Zone in Mice

Differential efferent projections of the anterior, posteroventral, and posterodorsal subdivisions of the medial amygdala in mice

Afferent and efferent projections of the anterior cortical amygdaloid nucleus in the mouse

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