Neural systems contributing to acetylcholinesterase histochemical staining in primary visual cortex of the adult rat

Robertson, Richard T.; Fehrenbach, Charles J.; Yü, Jen

doi:10.1016/0006-8993(90)90543-k

Cited by 23 publications

(4 citation statements)

References 60 publications

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“…Saper (1984), using anterograde transport of tritiated amino acids, suggested the presence of a medial pathway from the septum and diagonal band through the cingulate bundle to innervate medial cortex and a lateral pathway through the internal capsule to innervate lateral cortex. This notion has received further support from axonal tracing studies (Luiten et al, 1987(Luiten et al, , 1990 and from studies using placement of lesions to disrupt corticopetal basal forebrain axons (Robertson et al, 1990).…”

Section: Pathways From Basal Forebrain To Visual Cortexmentioning

confidence: 96%

“…Studies based on anterograde and retrograde transport techniques demonstrate that occipital cortex receives a projection primarily from neurons in the horizontal and vertical limbs of the diagonal band and, to a lesser extent, the substantia innominata (Bigl et al, 1982;Price and Stern, 1983;Lamour et al, 1984;Rye et al, 1984;Carey and Rieck, 1987;Luiten et al, 1990). Anterograde transport studies have demonstrated that BFB projections to cerebral cortex (Lamour et al, 1984;Saper, 1984;Luiten et al, 1987Luiten et al, , 1990) display a laminar pattern remarkably similar to patterns of endogenous acetyl cholinesterase (AChE) staining and choline acetyltransferase ( C U T ) immunoreactivity (Kristt et al, 1985;Lysakowski et al, 1986Lysakowski et al, , 1989Robertson et al, 1990), with greatest density in the deep cortical layers and in layer I.…”

Section: Indexing Terms: Axons Cholinergic Dendrites Diagonal Bandmentioning

confidence: 99%

“…The cerebral cortex receives prominent innervation from axons of cholinergic neurons situated in the basal forebrain (BFB; Divac, 1975;Divac et al, 1978;Wenk et al, 1980;Bigl et al, 1982;McKinney et al, 1983;Mesulam et al, 1983;Kristt et al, 1985). This cholinergic projection recently has attracted a great deal of interest from neuroscientists, and several recent morphological studies have investigated the organization of this pathway in adults (Wenk et al, 1980;Bigl et al, 1982;McKinney et al, 1983;Price and Stern, 1983;Lamour et al, 1984;Rye et al, 1984;Saper, 1984;Kristt et al, 1985;Luiten et al, 1987;Luiten et al, 1990;Robertson et al, 1990). Although in humans and other primates cholinergic neurons of the BFB are concentrated largely in the medial septa1 nucleus and the basal nucleus of Meynert, these cholinergic neurons are more dispersed in other species.…”

Section: Indexing Terms: Axons Cholinergic Dendrites Diagonal Bandmentioning

confidence: 99%

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Development of basal forebrain projections to visual cortex: Dil studies in rat

Calarco

Robertson

1995

J of Comparative Neurology

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We performed experiments using retrograde and anterograde labeling with DiI to examine the development of basal forebrain (BFB) projections to the visual cortex in postnatal rats. DiI placed in occipital cortex led to retrograde labeling of BFB neurons as early as postnatal day 0 (P0); labeled cells were found mainly in the diagonal band complex but also in the medial septum, globus pallidus, and substantia innominata. The retrogradely labeled BFB cells displayed remarkably well-developed dendritic arbors, even in younger animals, and showed increases in soma size, dendritic arbors, and dendritic spines over the first 2 postnatal weeks. DiI placements in the diagonal band led to anterogradely labeled axons in cortex. At early ages (P0-P1), labeled axons were largely confined to white matter. With increasing age, greater numbers of labeled axons were seen in the white matter and in deep cortical layers, and labeled axons extended into superficial layers. The leading edge of labeled fibers reached layer V of visual cortex by P2 and layer IV by P4 and were found throughout the cortical layers by P6. Numbers and densities of labeled axons in visual cortex were greater in older animals, at least through P14. The time of ingrowth of labeled BFB axons into visual cortex indicates that these afferents grow into particular cortical layers after those layers have differentiated from the cortical plate. These data indicate that basal forebrain projections arrive in occipital cortex after cortical lamination is well underway and after the entry of primary thalamocortical projections.

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Section: Pathways From Basal Forebrain To Visual Cortexmentioning

confidence: 96%

Section: Indexing Terms: Axons Cholinergic Dendrites Diagonal Bandmentioning

confidence: 99%

Section: Indexing Terms: Axons Cholinergic Dendrites Diagonal Bandmentioning

confidence: 99%

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Development of basal forebrain projections to visual cortex: Dil studies in rat

Calarco

Robertson

1995

J of Comparative Neurology

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“…AChE is expressed by the neuronal somata and dendrites, and also by the axons of cholinergic neurons, making it a reliable and valid marker for revealing the presence and morphological features of BFCNs. AChE-positive neurons also are a normal component of cortical regions, including the hippocampus, entorhinal cortex and neocortex (Levey et al, 1984;Lysakowski et al, 1989;Robertson et al, 1988Robertson et al, , 1990Seress et al, 1987). Interestingly, these AChE-positive neurons appear not to be cholinergic (Levey et al, 1984).…”

Section: Technical Considerationsmentioning

confidence: 99%

Basal forebrain cholinergic cell attachment and neurite outgrowth on organotypic slice cultures of hippocampal formation

et al. 2002

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Postnatal development of cholinergic markers in the rat olfactory bulb: A histochemical and immunocytochemical study

Jeune

Jourdan

1991

J of Comparative Neurology

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The present study has defined the developmental time course and the distribution patterns of neuronal fibers and cell bodies displaying acetylcholinesterase (AChE) activity or choline acetyltransferase (ChAT) immunoreactivity in the rat olfactory bulb. The results indicate that the deployment of centrifugal AChE-containing fibers is essentially postnatal. The subset of atypical glomeruli, including the modified glomerular complex, is innervated as early as the first postnatal day while the normal ones are not reached by this type of afferent before postnatal day 6. The comparison of AChE labelling with ChAT immunoreactivity strongly supports the assumption that AChE-containing fibers represent mainly, if not exclusively, the cholinergic bulbopetal innervation emanating from the basal forebrain. A quantitative study has confirmed that the density of labelled fibers increases gradually in the postnatal period and spreads heterogeneously among the bulbar layers. The selective precocious innervation of atypical glomeruli is in favor of their involvement in the early processing of olfactory information in the olfactory bulb. Acetylcholinesterase is also expressed within a subset of ChAT-negative interneurons of the developing olfactory bulb. The number of neurons expressing AChE increases from birth to postnatal day 15 and then decreases to reach the adult value on about postnatal day 30. This neuronal population could constitute a cholinoceptive subset mediating the effects of cholinergic afferents on the bulbar neuronal network.

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Neural systems contributing to acetylcholinesterase histochemical staining in primary visual cortex of the adult rat

Cited by 23 publications

References 60 publications

Development of basal forebrain projections to visual cortex: Dil studies in rat

Development of basal forebrain projections to visual cortex: Dil studies in rat

Basal forebrain cholinergic cell attachment and neurite outgrowth on organotypic slice cultures of hippocampal formation

Postnatal development of cholinergic markers in the rat olfactory bulb: A histochemical and immunocytochemical study

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