Neural tube derived Wnt signals cooperate with FGF signaling in the formation and differentiation of the trigeminal placodes

Canning, Claire Ann; Lee, Lily; Luo, Sarah Xinwei; Graham, Anthony; Jones, C. Michael

doi:10.1186/1749-8104-3-35

Cited by 45 publications

(66 citation statements)

References 31 publications

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“…This area will give rise to the otic, lateral line, and epibranchial placodes, with otic placodes being favored by Wnt and epibranchial placodes by persistent FGF signaling (Freter, Muta, Mak, Rinkwitz, & Ladher, 2008;Ladher, Anakwe, Gurney, Schoenwolf, & Francis-West, 2000;Nechiporuk, Linbo, Poss, & Raible, 2007;Ohyama, Mohamed, Taketo, Dufort, & Groves, 2006). The profundal placode marked by Pax3 expression and the trigeminal placode are induced in between by various signals (Wnt, FGF, PDGF) from the neural plate (Canning, Lee, Luo, Graham, & Jones, 2008;Lassiter et al, 2007;McCabe & Bronner-Fraser, 2008). …”

Section: Origin and Patterning Of Cranial Placodesmentioning

confidence: 97%

Vertebrate Cranial Placodes as Evolutionary Innovations—The Ancestor's Tale

Schlosser

2015

Current Topics in Developmental Biology

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Section: Origin and Patterning Of Cranial Placodesmentioning

confidence: 97%

Vertebrate Cranial Placodes as Evolutionary Innovations—The Ancestor's Tale

Schlosser

2015

Current Topics in Developmental Biology

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“…FGF and Wnt signaling pathways cross talk, in either cooperative or antagonistic fashions, in several developmental and cellular processes, such as embryonic morphogenesis and patterning, cell proliferation, cell fate determination and tissue induction (Gunhaga et al, 2003;Katoh, 2006;Takemoto et al, 2006;Canning et al, 2008;Hong et al, 2008). Cross-interaction between these pathways can further modulate individual fluctuations of each signal, generating specific intracellular environments in different tissues and/or developmental stages.…”

Section: Introductionmentioning

confidence: 99%

FGF/MAPK/Ets signaling renders pigment cell precursors competent to respond to Wnt signal by directly controllingCi-Tcftranscription

et al. 2011

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SUMMARYFGF and Wnt pathways constitute two fundamental signaling cascades, which appear to crosstalk in cooperative or antagonistic fashions in several developmental processes. In vertebrates, both cascades are involved in pigment cell development, but the possible interplay between FGF and Wnt remains to be elucidated. In this study, we have investigated the role of FGF and Wnt signaling in development of the pigment cells in the sensory organs of C. intestinalis. This species possesses the basic features of an ancestral chordate, thus sharing conserved molecular developmental mechanisms with vertebrates. Chemical and targeted perturbation approaches revealed that a FGF signal, spreading in time from early gastrulation to neural tube closure, is responsible for pigment cell precursor induction. This signal is transmitted via the MAPK pathway, which activates the Ci-Ets1/2 transcription factor. Targeted perturbation of Ci-TCF, a downstream factor of the canonical Wnt pathway, indicated its contribution to pigment cell differentiation Furthermore, analyses of the Ci-Tcf regulatory region revealed the involvement of the FGF effector, Ci-Ets1/2, in Ci-Tcf transcriptional regulation in pigment cell precursors. Our results indicate that both FGF and the canonical Wnt pathways are involved in C. intestinalis pigment cell induction and differentiation. Moreover, we present a case of direct transcriptional regulation exerted by the FGF signaling cascade, via the MAPK-ERK-Ets1/2, on the Wnt downstream gene CiTcf. Several examples of FGF/Wnt signaling crosstalk have been described in different developmental processes; however, to our knowledge, FGF-Wnt cross-interaction at the transcriptional level has never been previously reported. These findings further contribute to clarifying the multitude of FGF-Wnt pathway interactions.

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“…At the midbrain level of stage nine embryos, Pax3 protein expression was first observed in the dorsal part of the midbrain-level PPR (not shown), and at later stages such as stage 11, this expression expanded ventro-laterally (Fig. 2) as previously described by Canning et al 2008 at the mRNA level. Six1 expression confirmed the placodal identity of this Pax3-domain (Fig.…”

Section: Resultsmentioning

confidence: 55%

“…Previous studies indicated that platelet-derived growth factor and Wnt ligands provided by the midbrain and midbrain ⁄ hindbrain boundary region induce Pax3 expression expanding from a medial to ventro-lateral direction (Lassiter et al 2007;Canning et al 2008;McCabe & Bronner-Fraser 2008). Pax3 function is important for the promotion of further differentiation of trigeminal placode ⁄ sensory neurons (Dude et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Mutual repression between Pax3 and Pax6 is involved in the positioning of ophthalmic trigeminal placode in avian embryo

Wakamatsu

2011

Development, Growth &Amp; Differentiation

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Cranial sense organs and a subset of cranial sensory neurons are generated from placodes, thickenings of the ectoderm. Pax3 has been known as a marker for ophthalmic trigeminal placode specification, and also an important regulator of trigeminal placode neuron differentiation. In this study, I show that Pax6 is initially expressed in the preplacodal region at the level of ophthalmic trigeminal placode, and that this expression gradually regresses in a medial-to-lateral direction as Pax3 expression expands in the same direction. Misexpression studies revealed that Pax6 represses Pax3 expression indirectly as a transcriptional activator in a cell-autonomous manner. Pax3-misexpression represses Pax6 expression in an indirect fashion, suggesting that unknown factor(s) downstream of Pax3 may repress Pax6 expression, and thereby allow an expansion of Pax3-positive ophthalmic trigeminal placode region. These results indicate that the mutual repression between Pax3 and Pax6 has important roles in the specification and the positioning of the ophthalmic trigeminal placode.

show abstract

Neural tube derived Wnt signals cooperate with FGF signaling in the formation and differentiation of the trigeminal placodes

Cited by 45 publications

References 31 publications

Vertebrate Cranial Placodes as Evolutionary Innovations—The Ancestor's Tale

Vertebrate Cranial Placodes as Evolutionary Innovations—The Ancestor's Tale

FGF/MAPK/Ets signaling renders pigment cell precursors competent to respond to Wnt signal by directly controllingCi-Tcftranscription

Mutual repression between Pax3 and Pax6 is involved in the positioning of ophthalmic trigeminal placode in avian embryo

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