Neuraminidase Inhibitors from the Fruiting Body of <i>Phellinus igniarius</i>

Kim, Ji-Yul; Kim, Dae‐Won; Hwang, Byung Kook; Woo, E-Eum; Lee, Yoon-Ju; Jeong, Kyeong-Woon; Lee, In‐Kyoung; Yun, Bong‐Sik

doi:10.5941/myco.2016.44.2.117

Cited by 7 publications

(7 citation statements)

References 15 publications

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“…The components in Phellinus igniarius also showed good antiviral activity. Two compounds, the phelligridins E and G were isolated from the methanol extract of Phellinus igniarius fruiting bodies, which showed neuraminidase inhibitory activity against recombinant H1N1, H3N2, and H5N1 in a dose-dependent manner [ 19 ]. An in vitro experiment of Phellinus igniarius aqueous extract PIW shows that it has inhibitory activity on 2009 pandemic H1N1, human H3N2, avian H9N2, and oseltamivir-resistant H1N1 viruses, and its mechanism may be related to interfering with the early replication process of the virus [ 20 ].…”

Section: Antiviral Activitymentioning

confidence: 99%

Medicinal Fungi with Antiviral Effect

Zhang

Ling

2022

Molecules

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Pandemics from various viruses make natural organisms face challenges over and over again. Therefore, new antiviral drugs urgently need to be found to solve this problem. However, drug research and development is a very difficult task, and finding new antiviral compounds is desirable. A range of medicinal fungi such as Ganoderma lucidum and Cordyceps sinensis are widely used all over the world, and they can enhance human immunity and direct anti-virus activities and other aspects to play an antiviral role. Medicinal fungi are used as foods or as food supplements. In this review, the species of medicinal fungi with antiviral activity in recent decades and the mechanism of antiviral components were reviewed from the perspectives of human, animal, and plant viruses to provide a comprehensive theory based on better clinical utilization of medicinal fungi as antiviral agents.

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Section: Antiviral Activitymentioning

confidence: 99%

Medicinal Fungi with Antiviral Effect

Zhang

Ling

2022

Molecules

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“…The study on neuraminidase inhibitors also demonstrated the efficacy of P. igniarius extracts against the influenza virus. Two active compounds, phelligridin E and G, were isolated from the methanolic extract and were identified as neuraminidase inhibitors of H1N1, H3N2, and H5N1 strains with IC 50 values in the range of 0.7∼8.1 μM [50] …”

Section: Phellinus Igniariusmentioning

confidence: 99%

Selected Species of the Genus Phellinus – Chemical Composition, Biological Activity, and Medicinal Applications

Sułkowska-Ziaja

Balik

Muszyńska

2021

Chemistry & Biodiversity

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This study presents the current knowledge on chemical composition, biological activity, and possible medicinal applications of Phellinus igniarius, Phellinus pini, Phellinus pomaceus, and Phellinus robustus. These inedible arboreal species are phytopathogens that cause the enzymatic decomposition of wood. These species belong to the medicinal mushrooms and have been known for centuries in the traditional medicine of the Far East. They have been used as an effective remedy for stomach and intestinal ailments, diarrhea, and hemorrhages. Mycochemical studies have proved the presence of polysaccharides, phenolic compounds, and terpenoids. These compounds show biological activities such as anticancer, antioxidant, antiangiogenic, and antiviral. Research studies conducted using modern analytical methods have advanced the knowledge on the potential therapeutic use of compounds isolated not only from the fruiting bodies but also from biomass obtained with in vitro biotechnological methods.

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“…P. igniarius is rich in secondary metabolites with biological activities, such as polysaccharides, polyphenols, flavonoids, and other chemical species [ 4 , 5 ]. Phelligridins are a class of chemical compounds from P. igniarius that possess radical-scavenging activity and a broad range of pharmacological properties, and includes chemicals such as Phelligridin D and Phelligridin G [ 6 , 7 ]. Based on structural analyses, it has been postulated that hispidin is a key intermediate of phelligridins [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Screening for proteins related to the biosynthesis of hispidin and its derivatives in Phellinus igniarius using iTRAQ proteomic analysis

Guo

Liu

et al. 2021

BMC Microbiol

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Background Hispidin (HIP) and its derivatives, a class of natural fungal metabolites, possess complex chemical structures with extensive pharmacological activities. Phellinus igniarius, the most common source of HIP, can be used as both medicine and food. However, the biosynthetic pathway of HIP in P. igniarius remains unclear and we have a limited understanding of the regulatory mechanisms related to HIP. In this work, we sought to illustrate a biosynthesis system for hispidin and its derivatives at the protein level. Results We found that tricetolatone (TL) is a key biosynthetic precursor in the biosynthetic pathway of hispidin and that its addition led to increased production of hispidin and various hispidin derivatives. Based on the changes in the concentrations of precursors and intermediates, key timepoints in the biosynthetic process were identified. We used isobaric tags for relative and absolute quantification (iTRAQ) to study dynamic changes of related proteins in vitro. The 270 differentially expressed proteins were determined by GO enrichment analysis to be primarily related to energy metabolism, oxidative phosphorylation, and environmental stress responses after TL supplementation. The differentially expressed proteins were related to ATP synthase, NAD binding protein, oxidoreductase, and other elements associated with electron transfer and dehydrogenation reactions during the biosynthesis of hispidin and its derivatives. Multiple reaction monitoring (MRM) technology was used to selectively verify the iTRAQ results, leading us to screen 11 proteins that were predicted to be related to the biosynthesis pathways. Conclution These findings help to clarify the molecular mechanism of biosynthesis of hispidin and its derivatives and may serve as a foundation for future strategies to identify new hispidin derivatives.

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Neuraminidase Inhibitors from the Fruiting Body of Phellinus igniarius

Cited by 7 publications

References 15 publications

Medicinal Fungi with Antiviral Effect

Medicinal Fungi with Antiviral Effect

Selected Species of the Genus Phellinus – Chemical Composition, Biological Activity, and Medicinal Applications

Screening for proteins related to the biosynthesis of hispidin and its derivatives in Phellinus igniarius using iTRAQ proteomic analysis

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