Neuramins�urehaltige Glykoproteide des Liquor cerebrospinalis bei Erkrankungen des Nervensystems

The Neuraminic Acid Content of Cerebrospinal Fluid as Affected by Neurological Diseases*

“…In these states the increased NA content is of no greater significance than the nonspecific increase of CSF proteins. This conclusion supports the observa- tions of Ross and B6hm (17). In (16,17).…”

“…This conclusion supports the observa- tions of Ross and B6hm (17). In (16,17). The reason for this difference probably resides in the fact that the CSF contains about 15 times more proteins not precipitated by TCA than does serum, as was recently shown in a detailed study by Bauer (22).…”

“…The first form is represented by the fraction which is nondialyzable and partly precipitated by trichloracetic acid. This corresponds to the protein-bound forms studied by Bdhm, Baumeister and Ross (6,17). The second fraction is the freely dialyzable NA moiety of CSF.…”

“…were also observed in cases of meningitis where the CSF protein levels were proportionately elevated. Further studies by Ross and B6hm (17) on the protein-bound NA suggested a "normal" value of 2.7 ± 0.55 ug. per ml.…”

Studies on Sialic Acid (Neuraminic Acid) in Cerebrospinal Fluid

“…Roboz et al .29) used 70% one. Bohm et al 30,31) and Uzman et al 11,32) used 10% one. But we concluded that saturated solution was most suitable for this purpose and searched for a satisfactory procedures.…”