Neuregulin directed molecular mechanisms of visual cortical plasticity

Grieco, Steven F.; Holmes, Todd C.; Xu, Xiangmin

doi:10.1002/cne.24414

Cited by 18 publications

(20 citation statements)

References 118 publications

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“…While PV interneurons in the visual cortex express ErbB4 at high levels (Grieco et al, ; Gu et al, ; Sun et al, ), expression of the other ErbBs should also be examined. To test if ErbB4 forms heterodimers with other ErbBs allowing for NRG signaling (Mei & Nave, ) in PV neurons, the expression of four erbB family members were measured at P28, P56, and P104.…”

Section: Resultsmentioning

confidence: 99%

“…Neuregulins (NRGs) are a family of Epidermal Growth Factor (EGF) domain‐containing receptor ligands that are expressed in the nervous system, among which Neuregulin1 (NRG1) is best characterized. It was recently discovered that NRG1/ErbB4 signaling in parvalbumin (PV) inhibitory interneurons is critical for the initiation of visual cortical plasticity by controlling excitatory synaptic inputs onto PV neurons and thus PV cell mediated cortical disinhibition that occurs following visual deprivation (Grieco, Holmes, & Xu, ; Gu et al, ; Sun et al, ). However, there are multiple types of NRGs and ErbBs known to be involved in the development and function of the nervous system.…”

Section: Introductionmentioning

confidence: 99%

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Neuregulin and ErbB expression is regulated by development and sensory experience in mouse visual cortex

Grieco

Wang

Mahapatra

et al. 2019

J of Comparative Neurology

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Neuregulins (NRGs) are protein ligands that impact neural development and circuit function. NRGs signal through the ErbB receptor tyrosine kinase family. NRG1/ErbB4 signaling in parvalbumin-expressing (PV) inhibitory interneurons is critical for visual cortical plasticity. There are multiple types of NRGs and ErbBs that can potentially contribute to visual cortical plasticity at different developmental stages. Thus, it is important to understand the normal developmental expression profiles of NRGs and ErbBs in specific neuron types in the visual cortex, and to study whether and how their expression changes in PV inhibitory neurons and excitatory neurons track with sensory perturbation. Cell type-specific translating ribosome affinity purification and qPCR was used to compare mRNA expression of nrg1,2,3,4 and erbB1,2,3,4 in PV and excitatory neurons in mouse visual cortex. We show that the expression of nrg1 and nrg3 decreases in PV neurons at the critical period peak, postnatal day 28 (P28) after monocular deprivation and dark rearing, and in the adult cortex (at P104) after 2-week long dark exposure. In contrast, nrg1 expression by excitatory neurons is unchanged at P28 and P104 following sensory deprivation, whereas nrg3 expression by excitatory neurons shows changes depending on the age and the mode of sensory deprivation. ErbB4 expression in PV neurons remains consistently high and does not appear to change in response to sensory deprivation. These data provide new important details of cell type-specific NRG/ErbB expression in the visual cortex and support that NRG1/ErbB4 signaling is implicated in both critical period and adult visual cortical plasticity.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuregulin and ErbB expression is regulated by development and sensory experience in mouse visual cortex

Grieco

Wang

Mahapatra

et al. 2019

J of Comparative Neurology

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“…Neuregulin-3 (Nrg3) is a member of the neuregulin (Nrg1-4) family of growth factors, which play important roles in the developing and mature nervous system (Birchmeier & Bennett, 2016;Grieco, Holmes, & Xu, 2018;Mei & Nave, 2014;Mei & Xiong, 2008). Nrg3 is of particular interest as it has emerged as a candidate risk gene for several neuropsychiatric disorders including bipolar disorder and schizophrenia (SZ) (Avramopoulos, 2018; P. L. Chen et al, 2009;Hayes et al, 2016;Loos et al, 2014;Paterson et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Developmental expression of Neuregulin‐3 in the rat central nervous system

Rahman

Weber

Labin

et al. 2018

J of Comparative Neurology

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Neuregulin‐3 (Nrg3) is a member of the Nrg family of growth factors identified as risk factors for schizophrenia. There are three Nrgs expressed in the nervous system (Nrg1‐3) and of these Nrg1 has been the best characterized. To set the groundwork for elucidating neural roles for Nrg3, we studied its expression in the rat brain at both the RNA and protein levels. Using an antibody developed against Nrg3, we observed a developmental increase of Nrg3 protein expression from embryonic stages to adulthood and determined that it carries O‐linked carbohydrates. In cortical neuronal cultures, transfected Neuro2a cells, and brain tissue sections Nrg3 protein was localized to the soma, neurites, and to the Golgi apparatus, where it is prominently expressed. Nrg3 was detected in excitatory, GABAergic and parvalbumin‐expressing inhibitory neurons while expression in glia was limited. Nrg3 mRNA and protein were widely expressed during both embryonic and postnatal ages. At E17, Nrg3 was detected within the cortical plate and ventricular zone suggesting possible roles in cell proliferation or migration. At postnatal ages, Nrg3 was abundantly expressed throughout the cerebral cortex and hippocampus. Multiple thalamic nuclei expressed Nrg3, while detection in the striatum was limited. In the cerebellum, Nrg3 was found in both Purkinje cells and granule neurons. In the rodent brain, Nrg3 is the most abundantly expressed of the Nrgs and its patterns of expression differ both temporally and spatially from that of Nrg1 and Nrg2. These findings suggest that Nrg3 plays roles that are distinct from the other Nrg family members.

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“…We next reasoned that the physiological impact of ketamine-mediated reduction in inhibitory input to excitatory pyramidal neurons might be reversed by enhancing NRG1/ErbB4 signaling. This was motivated by our previous findings that NRG1 strongly modulates evoked synaptic inhibition to pyramidal neurons in visual cortical slices when NRG1/ErbB4 signaling is downregulated (Grieco et al, 2019a;Sun et al, 2016) recombinant NRG1 containing the epidermal growth factor (EGF) core domain of NRG1-β1 applied to the bath greatly reverses reductions in inhibitory inputs to the same group of L2/3 pyramidal cells recorded from visual cortex of the mice receiving in vivo ketamine treatment only shortly before ( Figure 2D).…”

Section: Cortical Disinhibition Evoked By Subanesthetic In Vivo Ketaminementioning

confidence: 99%

“…Neuregulin-1 (NRG1) is essential for the normal development of the nervous system, and signaling through its tyrosine kinase receptor ErbB4 has been implicated in visual cortical plasticity (Sun et al, 2016;Gu et al, 2016;Grieco et al, 2019a). Our previous work demonstrates that PV inhibitory interneurons are the initial circuit locus for the establishment of visual cortex critical period plasticity (Kuhlman et al, 2013).…”

Section: Introductionmentioning

confidence: 99%