Neurexophilin and PC‐esterase domain family member 4 (<i>NXPE4</i>) and prostate androgen‐regulated mucin‐like protein 1 (<i>PARM1</i>) as prognostic biomarkers for colorectal cancer

Liu, Yarui; Hu, Yang; Zeng, Ying; Li, Zhixing; Zhang, Haibo; Deng, Jun‐Li; Guo, Wei

doi:10.1002/jcb.29107

Cited by 15 publications

(7 citation statements)

References 42 publications

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“…3,12 Several esterases have previously been reported to be dysregulated in specific cancers, with some also having the potential to be predictive or prognostic biomarkers. For example, low expression of neurexophilin and PC-esterase domain family member 4 (NXPE4) mRNA is a prognostic marker for shorter survival in patients with colorectal cancer, 13 and expression of platelet-activating factor acetylhydrolase 1B2 (PAFAH1B2) is inversely correlated with patient survival in pancreatic ductal adenocarcinoma. 14 In lung cancer, acetylcholinesterase (ACHE) may act as a tumour suppressor and is downregulated, 15 and high expression of granzyme A (GZMA) is significantly associated with an improved prognosis in multiple cancer types.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of esterase gene expression in multiple myeloma

et al. 2021

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Background Esterase enzymes differ in substrate specificity and biological function and may display dysregulated expression in cancer. This study evaluated the biological significance of esterase expression in multiple myeloma (MM). Methods For gene expression profiling and evaluation of genomic variants in the Institute for Molecular Medicine Finland (FIMM) cohort, bone marrow aspirates were obtained from patients with newly diagnosed MM (NDMM) or relapsed/refractory MM (RRMM). CD138+ plasma cells were enriched and used for RNA sequencing and analysis, and to evaluate genomic variation. The Multiple Myeloma Research Foundation (MMRF) Relating Clinical Outcomes in MM to Personal Assessment of Genetic Profile (CoMMpass) dataset was used for validation of the findings from FIMM. Results MM patients (NDMM, n = 56; RRMM, n = 78) provided 171 bone marrow aspirates (NDMM, n = 56; RRMM, n = 115). Specific esterases exhibited relatively high or low expression in MM, and expression of specific esterases (UCHL5, SIAE, ESD, PAFAH1B3, PNPLA4 and PON1) was significantly altered on progression from NDMM to RRMM. High expression of OVCA2, PAFAH1B3, SIAE and USP4, and low expression of PCED1B, were identified as poor prognostic markers (P < 0.05). The MMRF CoMMpass dataset provided validation that higher expression of PAFAH1B3 and SIAE, and lower expression of PCED1B, were associated with poor prognosis. Conclusions Esterase gene expression levels change as patients progress from NDMM to RRMM. High expression of OVCA2, PAFAH1B3, USP4 and SIAE, and low expression of PCED1B, are poor prognostic markers in MM, suggesting a role for these esterases in myeloma biology.

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Section: Introductionmentioning

confidence: 99%

Prognostic significance of esterase gene expression in multiple myeloma

et al. 2021

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“…Large numbers of gene expression datasets for CRC are available in the Gene Expression Omnibus (GEO) database, and numerous studies have used these datasets for the identification of differentially expressed genes (DEGs) in CRC (6–9). Previous studies have revealed the prognostic value of certain DEGs in CRC (10–13). However, the results of these individual studies varied and the studies demonstrated differences in sample collection, platform types and analysis methods.…”

Section: Introductionmentioning

confidence: 99%

Four targeted genes for predicting the prognosis of colorectal cancer: A bioinformatics analysis case

et al. 2019

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The molecular mechanisms underlying the development and progression of colorectal cancer (CRC) have not been clarified. The purpose of the present study was to identify key genes that may serve as novel therapeutic targets or prognostic predictors in patients with CRC using bioinformatics analysis. Four gene expression datasets were downloaded from the Gene Expression Omnibus database, which revealed 19 upregulated and 34 downregulated differentially expressed genes (DEGs). The downregulated DEGs were significantly enriched in eight pathways according to Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. A protein-protein interaction network was constructed with 52 DEGs and 458 edges. Ten key genes were identified according to the degree value, betweenness centrality and closeness centrality. Survival analysis revealed that low expression of four of the ten genes, carcinoembryonic antigen related cell adhesion molecule 7 (CEACAM7), solute carrier family 4 member 4 (SLC4A4), glucagon (GCG) and chloride channel accessory 1 (CLCA1) genes, were associated with unfavorable prognosis in CRC. Furthermore, gene set enrichment analysis revealed that two pathways were significantly enriched in the CEACAM7 low-expression group. Thus, CEACAM7, SLC4A4, GCG and CLCA1 may be prognostic markers or therapeutic targets of CRC. Low CEACAM7 expression may be associated with the activation of glycosaminoglycan biosynthesis-chondroitin sulfate and extracellular matrix receptor interaction pathways and may affect the prognosis of CRC.

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“…The PARM1 gene encodes a prostate androgen-regulated mucin-like protein 1. PARM1 has first been described as a transcript specifically upregulated in the rat ventral prostate after castration 28 and, since it is involved in the cell proliferation enhancement, it has been suggested as a potential oncogene and prognostic biomarker for colorectal cancer 29,30 . However, no specific function of this transcript in the brain has been described to date.…”

Section: Resultsmentioning

confidence: 99%

Identification of transcriptome alterations in the prefrontal cortex, hippocampus, amygdala and hippocampus of suicide victims

Glăvan

Gheorman

Gresita

et al. 2021

Sci Rep

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Suicide is one of the leading causes of death globally for all ages, and as such presents a very serious problem for clinicians worldwide. However, the underlying neurobiological pathology remains to a large extent unknown. In order to address this gap, we have carried out a genome-wide investigation of the gene expression in the amygdala, hippocampus, prefrontal cortex and thalamus in post-mortem brain samples obtained from 20 suicide completers and 7 control subjects. By KEGG enrichment analysis indicated we identified novel clusters of downregulated pathways involved in antigen neutralization and autoimmune thyroid disease (amygdala, thalamus), decreased axonal plasticity in the hippocampus. Two upregulated pathways were involved in neuronal death in the hippocampus and olfactory transduction in the thalamus and the prefrontal cortex. Autoimmune thyroid disease pathway was downregulated only in females. Metabolic pathways involved in Notch signaling amino acid metabolism and unsaturated lipid synthesis were thalamus-specific. Suicide-associated changes in the expression of several genes and pseudogenes that point to various functional mechanisms possibly implicated in the pathology of suicide. Two genes (SNORA13 and RNU4-2) involved in RNA processing were common to all brain regions analyzed. Most of the identified gene expression changes were related to region-specific dysregulated manifestation of genetic and epigenetic mechanisms underlying neurodevelopmental disorders (SNORD114-10, SUSd1), motivation, addiction and motor disorders (CHRNA6), long-term depression (RAB3B), stress response, major depression and schizophrenia (GFAP), signal transduction at the neurovascular unit (NEXN) and inhibitory neurotransmission in spatial learning, neural plasticity (CALB2; CLIC6, ENPP1). Some of the differentially expressed genes were brain specific non-coding RNAs involved in the regulation of translation (SNORA13). One, (PARM1) is a potential oncogene and prognostic biomarker for colorectal cancer with no known function in the brain. Disturbed gene expression involved in antigen neutralization, autoimmunity, neural plasticity, stress response, signal transduction at the neurovascular unit, dysregulated nuclear RNA processing and translation and epigenetic imprinting signatures is associated with suicide and point to regulatory non-coding RNAs as potential targets of new drugs development.

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Neurexophilin and PC‐esterase domain family member 4 (NXPE4) and prostate androgen‐regulated mucin‐like protein 1 (PARM1) as prognostic biomarkers for colorectal cancer

Cited by 15 publications

References 42 publications

Prognostic significance of esterase gene expression in multiple myeloma

Prognostic significance of esterase gene expression in multiple myeloma

Four targeted genes for predicting the prognosis of colorectal cancer: A bioinformatics analysis case

Identification of transcriptome alterations in the prefrontal cortex, hippocampus, amygdala and hippocampus of suicide victims

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