Neurilemoma-like uterine myomas: An ultrastructural reaffirmation of their non-Schwannian nature

Gisser, Susan D.; Young, Irving

doi:10.1016/0002-9378(77)90582-8

Cited by 22 publications

(12 citation statements)

References 3 publications

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“…These tumors have usually been observed in young women ranging from 25 years of age to perimenopausal age, and their symptoms are typically associated with the location and size of the tumor; in several cases, abnormal vaginal bleeding was described as a symptom. Moreover, tumor sizes ranging from 1.5 cm to 7 cm have been described (Gisser and Young, 1977), but tumors with large volume of this type of cervical origin has not been previously described.…”

Section: Discussionmentioning

confidence: 99%

“…Tumor subtypes with unusual histological patterns have also been described, including leiomyomas with schwannoma-like or neurilemmoma-like differentiation. Because these tumors are very rare, preoperative diagnosis is difficult, and their characteristics are often only determined after surgery and histological study (Gisser and Young, 1977). Specifically, these tumors exhibit a regular, spindle-shaped cellular pattern that suggests a peripheral nerve sheath tumor (Gisser and Young, 1977, Kempson and Hendrickson, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Surgical management of a large neurilemmoma-like leiomyoma of the uterine cervix mimicking a retroperitoneal tumor

Morales

Suescún

Martínez

et al. 2017

Gynecologic Oncology Reports

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surgical management of a large neurilemmoma-like leiomyoma of the uterine cervix mimicking a retroperitoneal tumor

Morales

Suescún

Martínez

et al. 2017

Gynecologic Oncology Reports

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“…In the present examination, two of 164 pleomorphic adenomas showed multiple foci of spindleshaped MMCs with a nuclear palisading arrangement in myxoid areas. To examine one possibility, we postulated that such palisading arrangement of MMCs might be suggestive of differentiation or transformation of MMCs into cells more smooth muscle in nature, because of the palisading leiomyoma occasionally seen in the myometrium and gastrointestinal tract 2,5,7,12) . However, immunohistochemical findings of palisading MMCs in pleomorphic adenoma were similar to those of non-palisading MMCs 3,10,11) , and no evidence of the smooth muscle differentiation reported in spindle cell stromal tumors 2,5,12) .…”

Section: Discussionmentioning

confidence: 99%

Pleomorphic adenoma with nuclear palisading arrangement of modified myoepithelial cells: Histopathologic and immunohistochemical study.

Takeda

Shimono

1999

Bull. Tokyo Dent. Coll.

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Pleomorphic adenomas with a nuclear palisading arrangement of spindle-shaped modified myoepithelial cells (MMCs), suggesting the appearance of palisading leiomyoma or Antoni's A type of neurilemmoma, are quite rare, and its cytologic nature has been poorly understood. This paper reports histologic and immunohistochemical findings of palisading MMCs in two cases of pleomorphic adenoma. Histologically, foci of spindle-shaped MMCs with nuclei in a palisading arrangement were scattered in the myxoid areas. Near the large foci of spindle-shaped MMCs with nuclear palisading arrangements, tiny foci of spindle-shaped MMCs forming nuclear palisading or rosettelike arrangements were seen. Such nuclear palisading arrangements of MMCs were suggestive of differentiation or transformation of MMCs into cells that were more smooth muscle in nature, supported by occasional existence of palisading leiomyoma in the myometrium and gastrointestinal tract. However, immunohistochemical findings of palisading MMCs in pleomorphic adenoma were similar to those of non-palisading MMCs, and showed no evidence of smooth muscle differentiation; neither palisading nor non-palisading MMCs in pleomorphic adenoma expressed desmin, muscle specific actin (HHF-35), alpha smooth muscle actin, or myoglobin.The biologic significance and formative mechanism of nuclear palisading arrangement of MMCs in pleomorphic adenoma could not be determined in the present study. However, if the MMCs with nuclear palisading arrangements in pleomorphic adenoma, presented here, are aspirated for cytologic diagnosis or are included in a small biopsy specimen, the correct diagnosis of pleomorphic adenoma may be confused by a suspicion of myogenic or neurogenic tumor.

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“…The benign uterine smooth muscle neoplasms include leiomyoma of usual type, cellular leiomyoma, 2 mitotically active leiomyoma, 3 leiomyoma with bizarre nuclei (synonyms: 'pleomorphic/symplastic' leiomyoma and previously termed atypical leiomyoma according to the WHO 2003) [4][5][6][7] leiomyoma with secondary hormonal changes, 8 leiomyoma with hydropic degeneration, 9 apoplectic leiomyoma 10 and rare subtypes like plexiform leiomyoma, 3 epithelioid leiomyoma, 11 myxoid leiomyoma 12 lipoleiomyoma, 13,14 leiomyoma with hematopoietic elements, 15 and neurilemmoma (schwannoma)-like leiomyoma. 16 Leiomyomas mainly occur in women of reproductive age with a frequency as high as 77% if hysterectomy specimens are carefully investigated. 3 In addition, there is strong evidence that these tumors are hormonally responsive and dependent.…”

Section: Introductionmentioning

confidence: 99%

Exploring chromosomal abnormalities and genetic changes in uterine smooth muscle tumors

et al. 2016

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Smooth muscle tumors of the uterus are a diagnostically challenging group of tumors. Molecular surrogate markers reliably distinguishing between benign and malignant tumors are not available. Therefore, the diagnosis is based on morphologic criteria. The aim was to investigate a well-characterized group of challenging uterine smooth muscle tumors consisting of 20 leiomyomas, 13 leiomyomas with bizarre nuclei, and 14 leiomyosarcomas for copy number alterations, MED12 mutations and FH deletions to search for potential diagnostically useful surrogate markers. MED12 mutations were detected in 47, 15, and 25% of leiomyomas, leiomyomas with bizarre nuclei and leiomyosarcomas, respectively. MED12 mutations in leiomyomas with bizarre nuclei were detected outside the hotspot region. FH-deletions were seen in 27, 30.8, and 25% of leiomyomas, leiomyomas with bizarre nuclei and leiomyosarcomas, respectively. By using copy number alteration profiling a clear separation of leiomyomas, leiomyomas with bizarre nuclei and leiomyosarcomas could not be observed. Copy number alterations revealed clear genetic similarities between leiomyomas with bizarre nuclei and leiomyosarcomas. Leiomyosarcomas showed a similar pattern of gains and losses as leiomyomas with bizarre nuclei, with additional copy number alterations and more homozygous losses and high-level amplifications compared to leiomyomas with bizarre nuclei. In conclusion, this study demonstrates that known FH-deletions, a recurrent molecular change in leiomyomas, occur in morphologically challenging variants of leiomyomas, leiomyomas with bizarre nuclei and leiomyosarcomas. Although MED12 mutations are common in leiomyomas, they infrequently occur in leiomyomas with bizarre nuclei and leiomyosarcomas. The genetic similarities between leiomyomas with bizarre nuclei and leiomyosarcomas raise the intriguing possibility that uterine leiomyomas with bizarre nuclei and leiomyosarcomas are closely related and challenge the traditional concept that leiomyoma with bizarre nuclei is a tumor with just marked 'degenerative' cellular changes. These findings support the hypothesis that tumor progression within uterine smooth muscle tumors might occur.

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Neurilemoma-like uterine myomas: An ultrastructural reaffirmation of their non-Schwannian nature

Cited by 22 publications

References 3 publications

Surgical management of a large neurilemmoma-like leiomyoma of the uterine cervix mimicking a retroperitoneal tumor

Surgical management of a large neurilemmoma-like leiomyoma of the uterine cervix mimicking a retroperitoneal tumor

Pleomorphic adenoma with nuclear palisading arrangement of modified myoepithelial cells: Histopathologic and immunohistochemical study.

Exploring chromosomal abnormalities and genetic changes in uterine smooth muscle tumors

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