Neuritic Manifestations in Diabetes Mellitus

Jordan, William R.

doi:10.1001/archinte.1936.00170060069004

Cited by 299 publications

(34 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 1882, the 'Rapport du Congres' published in London, named these distinct pathological changes as 'Charcot's joint'. Since then case reports of CN in association with neurological disorders other than tabes dorsalis have been made and in 1936 Jordan made the first report of CN in diabetes mellitus [19]. Several neurological conditions such as spina bifida, meningomyelocele, cerebral palsy, syringomyelia have been associated with the development of CN [20,21].…”

Section: Historymentioning

confidence: 99%

Charcot neuroarthropathy in diabetes mellitus

et al. 2002

View full text Add to dashboard Cite

Charcot neuroarthropathy has been recognised for over 130 years and yet it remains a major cause of morbidity for patients with diabetes mellitus and a continuing challenge for physicians. It is rare but it seems to be increasing in prevalence and this provides hope that with larger studies it will soon be possible to clarify the natural history and optimal treatment regimens. The underlying cause is thought to be trauma in a neuropathic foot that leads to a complex series of pathological processes culminating in bone and joint destruction and subsequent deformity. The acute reaction is often misdiagnosed and many patients present late with established deformity. Even when the diagnosis is considered at an early stage there are no definitive criteria or tests to confirm charcot neuroarthropathy and a high index of suspicion is necessary in any diabetic patient with a swollen warm foot in the presence of somatic or autonomic neuropathy. Treatment has traditionally involved the use of various methods to avoid weight bearing but recent work has begun to suggest that bisphosphonates might be able to arrest the acute process. In the long term, treatment involves a multidisciplinary approach aimed at providing appropriate footwear to reduce plantar pressures and avoid foot ulceration; in some circumstances this involves surgical correction of deformities before adequate footwear can be supplied. Further studies of the emerging treatments for Charcot neuroarthropathy are needed to provide long-term outcome data on morbidity and deformity.

show abstract

Section: Historymentioning

confidence: 99%

Charcot neuroarthropathy in diabetes mellitus

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Aseptic arthropathy in diabetes mellitus is classically characterized as the cause of underlying abnormalities of nervous tissue because diabetes mellitus causes peripheral nerve fragility [2]. The loss of somatic and autonomic nervous functions in diabetes mellitus is the principal factor in neuropathic arthropathy, which leads to joint destruction [3][4][5][6].…”

Section: Discussionmentioning

confidence: 99%

Allograft bone transplantation for neuropathic arthropathy of the knee associated with type 1 diabetes mellitus

2013

View full text Add to dashboard Cite

“…In diabetic neuropathy, the duration of diabetes prior to the onset of the neurological symptoms may vary from several weeks to several years [8], yet the average duration of the diabetes prior to the onset of clinical neuropathy was 5.9 years in Jordan's series of 120 cases [9]. In 28 of them, however, diabetes had been present for 1 year or less.…”

Section: Discussionmentioning

confidence: 99%

Uncommon early-onset neuropathy in diabetic patients

Saïd

Bigo

Ameri³

et al. 1998

Journal of Neurology

View full text Add to dashboard Cite

An acute neuropathy rarely occurs early in the course of diabetes mellitus. Five cases are described of adult patients who developed a peripheral neuropathy at the time or shortly after the onset or discovery of diabetes mellitus. Patient 1, an 80-year-old woman who developed a subacute tetraparesis with proximal and distal muscle weakness with normal cranial nerves, proved to have insulin-requiring diabetes mellitus. In the other patients, all men aged 23-34 years, symptomatic neuropathy occurred simultaneously (patient 2) or 1-6 months after the onset of insulin-dependent diabetes mellitus (IDDM) (patients 3-5). Patients 2 and 3 developed a symptomatic multifocal neuropathy; patients 4 and 5, a painful distal symmetrical sensory polyneuropathy (DSSP) shortly after beginning treatment with insulin. Nerve biopsy showed active axonal lesions in patients 2 and 5 and mixed axonal and demyelinating lesions in the others, with severe axon loss in patients 4 and 5. Vasculitic lesions were found in patient 2, who improved without additional treatment. Neurological examination remained unchanged after 2 years in patients 3-5. Although a coincidence cannot be excluded for patients 1-3, whose neuropathy was not of the pattern commonly found in diabetes, it is suggested that acute disequilibrium in the diabetic status may facilitate the occurrence of a variety of neuropathies. Alternatively, the autoimmune process which led to IDDM may also trigger an autoimmune neuropathy with vasculitis (patient 2) or demyelinative nerve lesions. Only the distal symmetrical sensory polyneuropathy with severe axonal lesions observed in patients 4 and 5 seems directly related to diabetes mellitus. In spite of their occurrence shortly after beginning insulin therapy, the role of treatment with insulin in the onset is uncertain.

show abstract

Neuritic Manifestations in Diabetes Mellitus

Cited by 299 publications

References 73 publications

Charcot neuroarthropathy in diabetes mellitus

Charcot neuroarthropathy in diabetes mellitus

Allograft bone transplantation for neuropathic arthropathy of the knee associated with type 1 diabetes mellitus

Uncommon early-onset neuropathy in diabetic patients

Contact Info

Product

Resources

About