Neuro- and nephroprotective effect of grape seed proanthocyanidin extract against carboplatin and thalidomide through modulation of inflammation, tumor suppressor protein p53, neurotransmitters, oxidative stress and histology

Yousef, Mokhtar I.; Khalil, Dina K.A.M.; Abdou, Heba M.

doi:10.1016/j.toxrep.2018.04.006

Cited by 32 publications

(19 citation statements)

References 58 publications

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“…It also suppressed mechanical and thermal hypersensitivity in rats while a decline of astrocytes activation in the spinal cord was monitored. The grape seed proanthocyanidin extract also showed neuroprotective power against carboplatin in a study reported by Yousef et al [ 137 ]. The main way of acting was through decreasing the oxidative stress in brain tissue and reducing cytokines, p53, neurotransmitters and biochemical parameters.…”

Section: Antioxidants In the Treatment Of Platinum-based Chemothermentioning

confidence: 93%

Antioxidant Supplementation in the Treatment of Neurotoxicity Induced by Platinum-Based Chemotherapeutics—A Review

Stanković

Selaković

Mihailović

et al. 2020

IJMS

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Cancer represents one of the most pernicious public health problems with a high mortality rate among patients worldwide. Chemotherapy is one of the major therapeutic approaches for the treatment of various malignancies. Platinum-based drugs (cisplatin, oxaliplatin, carboplatin, etc.) are highly effective chemotherapeutic drugs used for the treatment of several types of malignancies, but their application and dosage are limited by their toxic effects on various systems, including neurotoxicity. Simultaneously, researchers have tried to improve the survival rate and quality of life of cancer patients and decrease the toxicity of platinum-containing drugs by combining them with non-chemotherapy-based drugs, dietary supplements and/or antioxidants. Additionally, recent studies have shown that the root cause for the many side effects of platinum chemotherapeutics involves the production of reactive oxygen species (ROS) in naive cells. Therefore, suppression of ROS generation and their inactivation with antioxidants represents an appropriate approach for platinum drug-induced toxicities. The aim of this paper is to present an updated review of the protective effects of different antioxidant agents (vitamins, dietary antioxidants and supplements, medicaments, medicinal plants and their bioactive compounds) against the neurotoxicity induced by platinum-based chemotherapeutics. This review highlights the high potential of plant antioxidants as adjuvant strategies in chemotherapy with platinum drugs.

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Section: Antioxidants In the Treatment Of Platinum-based Chemothermentioning

confidence: 93%

Antioxidant Supplementation in the Treatment of Neurotoxicity Induced by Platinum-Based Chemotherapeutics—A Review

Stanković

Selaković

Mihailović

et al. 2020

IJMS

View full text Add to dashboard Cite

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“…Grape seed extract is found to reduce severe acute tubular necrosis and improve kidney function in cisplatin-treated rabbits, partially showing its protective effect against nephrotoxicity (Benzer et al, 2012 ). Recently, grape seed proanthocyanidin extract reduces thalidomide and carboplatin combination-induced renal damage in rats by reducing oxidative stress, inflammation, p53 change, and apoptosis (Yousef et al, 2018 ), as well as attenuates arsenic-induced renal inflammatory injury in mice by inhibiting NF-κB signaling activation and inflammatory cytokine production (Wang C. et al, 2017 ). Up to 2,500 mg of this extract administration for 4 weeks is found to be generally safe and well-tolerated in humans (Sano, 2017 ).…”

Section: Capacity To Relief Nephrotoxicitymentioning

confidence: 99%

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

et al. 2018

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Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy are the common cancer treatments. However, the development of adverse effects resulting from chemotherapy and radiotherapy hinders the clinical use, and negatively reduces the quality of life in cancer patients. Natural products including crude extracts, bioactive components-enriched fractions and pure compounds prepared from herbs as well as herbal formulas have been proved to prevent and treat cancer. Of significant interest, some natural products can reduce chemotherapy and radiotherapy-induced oral mucositis, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, hematopoietic system injury, cardiotoxicity, and neurotoxicity. This review focuses in detail on the effectiveness of these natural products, and describes the possible mechanisms of the actions in reducing chemotherapy and radiotherapy-induced side effects. Recent advances in the efficacy of natural dietary supplements to counteract these side effects are highlighted. In addition, we draw particular attention to gut microbiotan in the context of prebiotic potential of natural products for the protection against cancer therapy-induced toxicities. We conclude that some natural products are potential therapeutic perspective for the prevention and treatment of chemotherapy and radiotherapy-induced side effects. Further studies are required to validate the efficacy of natural products in cancer patients, and elucidate potential underlying mechanisms.

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“…In a study conducted in 2018, Yousef et al [ 60 ] explored the neuroprotective and nephroprotective effects of GSPE on the modulation of inflammation, the tumor suppressor protein p53, neurotransmitters, oxidative stress, and histology. The combination of thalidomide and carboplatin is one of the most effective chemotherapeutic strategies for the treatment of cancer.…”

Section: Studies Related To the Neuroprotective Effectmentioning

confidence: 99%

Health Effects of Grape Seed and Skin Extracts and Their Influence on Biochemical Markers

et al. 2020

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This review is focused on the study of the effects of grape seed and skin extract (GSSE) on human health. GSSE contains high concentrations of important polyphenolic substances with high biological activity. This review is a summary of studies that investigate the effects of GSSE on diabetes mellitus, cardiovascular disease and cancer, its neuroprotective effect, and its effects on the gastrointestinal tract and other health complications related to these diseases. The results of the studies confirm that the anti-inflammatory, antiapoptotic, and pro-proliferative effects of “Vitis vinifera L.” seed extract reduce the level of oxidative stress and improve the overall lipid metabolism.

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Neuro- and nephroprotective effect of grape seed proanthocyanidin extract against carboplatin and thalidomide through modulation of inflammation, tumor suppressor protein p53, neurotransmitters, oxidative stress and histology

Cited by 32 publications

References 58 publications

Antioxidant Supplementation in the Treatment of Neurotoxicity Induced by Platinum-Based Chemotherapeutics—A Review

Antioxidant Supplementation in the Treatment of Neurotoxicity Induced by Platinum-Based Chemotherapeutics—A Review

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

Health Effects of Grape Seed and Skin Extracts and Their Influence on Biochemical Markers

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