Neuro-inflammatory response in rats chronically exposed to 137Cesium

Lestaevel, Philippe; Grandcolas, Line; Paquet, F.; Voisin, Philippe; Aigueperse, Jocelyne; Gourmelon, P.

doi:10.1016/j.neuro.2008.01.001

Cited by 24 publications

(10 citation statements)

References 30 publications

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“…Th ere are studies in literature that support radiation-induced neuroimmune and infl ammatory response (Gourmelon et al 2005, Lestaevel et al 2008. It has already been stated that neuro-infl ammatory brain response may bring out electrophysiological and biochemical alterations (Lestaevel et al 2008). In the present study, change in mI levels post irradiation might be associated with neuro-infl ammatory response of microglial cells.…”

Section: Discussionmentioning

confidence: 99%

Altered brain metabolism after whole body irradiation in mice: A preliminary in vivo¹H MRS study

Rana¹,

Khan²,

Modi³

et al. 2012

International Journal of Radiation Biology

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Section: Discussionmentioning

confidence: 99%

Altered brain metabolism after whole body irradiation in mice: A preliminary in vivo¹H MRS study

Rana¹,

Khan²,

Modi³

et al. 2012

International Journal of Radiation Biology

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“…We thus developed in our laboratory a rodent model of chronic contamination through ingestion of drinking water containing radionuclides. Animal models showed that chronic exposure to a low concentration of 137 Cs in drinking water induced modifications in several physiological systems, such as the central nervous system (Lestaevel et al, 2006(Lestaevel et al, , 2008 and several metabolisms (Grignard et al, 2008;Tissandie et al, 2009). However no pathological consequences were observed in association with these modifications (Lestaevel et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Chronic exposure to low concentrations of strontium 90 affects bone physiology but not the hematopoietic system in mice

Synhaeve

Wade‐Gueye

Musilli

et al. 2012

J of Applied Toxicology

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The aim of this work was to delineate the effects of chronic ingestion of strontium 90 ((90) Sr) at low concentrations on the hematopoiesis and the bone physiology. A mouse model was used for that purpose. Parent animals ingested water containing 20 kBq l(-1) of (90) Sr two weeks before mating. Offspring were then continuously contaminated with (90) Sr through placental transfer during fetal life, through lactation after birth and through drinking water after weaning. At various ages between birth and 20 weeks, animals were tested for hematopoietic parameters such as blood cell counts, colony forming cells in spleen and bone marrow and cytokine concentrations in the plasma. However, we did not find any modification in (90) Sr ingesting animals as compared with control animals. By contrast, the analysis of bone physiology showed a modification of gene expression towards bone resorption. This was confirmed by an increase in C-telopeptide of collagen in the plasma of (90) Sr ingesting animals as compared with control animals. This modification in bone metabolism was not linked to a modification of the phosphocalcic homeostasis, as measured by calcium, phosphorus, vitamin D and parathyroid hormone in the blood. Overall these results suggest that the chronic ingestion of (90) Sr at low concentration in the long term may induce modifications in bone metabolism but not in hematopoiesis.

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“…Earlier, altered tau and mI levels in brain have been considered to be associated with osmotic dysregulation and neuroinflammation 7,8 . It has been shown that radiation induced neuroimmune and inflammatory response 3,27,28 may bring out electrophysiological and biochemical alterations 27 . Altered mI is usually interpreted to indicate as glial activation and macrophage infiltration 29 .…”

Section: Discussionmentioning

confidence: 99%

Early Differential Neurometabolite Response of Hippocampus on Exposure to Graded dose of Whole Body Radiation: An in Vivo 1H MR Spectroscopy Study

et al. 2017

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Whole body radiation exposure induced injury may occur during medical or industrial accidents as well as during terrorist radiation exposure scenario. A lot of information is available on alterations in brain function and metabolism post localised cranial irradiation; changes in brain associated with whole body radiation exposure are still limited. The present study has been conducted to assess early differential effect of low and high whole body radiation exposure on hippocampus neurometabolites using in vivo proton magnetic resonance spectroscopy ( 1 H MRS). Hippocampal 1 H MRS was carried out in controls (n = 6) and irradiated mice exposed to 3 Gy, 5 Gy, and 8 Gy of radiation (n = 6 in each group) at different time points i.e., day 0, 1, 3, 5 and 10 post irradiation at 7 T MRI system. Quantitative assessment of the neurometabolites was done using LCModel. The results revealed significant decrease in myoionisitol (mI)/creatine (tCr) and taurine (tau)/tCr in animals exposed to 5 Gy and 8 Gy dose compared to controls. In 3 Gy dose group, none of the metabolites showed significant alterations at any of the time point post irradiation as compared to controls. Overall our findings suggest differential change in hippocampal volume regulatory mechanism associated neuro-metabolites following whole body radiation exposure with maximum reduction in case of high dose group. We speculate that these alterations may be a consequence of oxidative stress, neuro inflammation or systemic inflammatory response following whole body radiation exposure.

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Neuro-inflammatory response in rats chronically exposed to 137Cesium

Cited by 24 publications

References 30 publications

Altered brain metabolism after whole body irradiation in mice: A preliminary in vivo¹H MRS study

Altered brain metabolism after whole body irradiation in mice: A preliminary in vivo¹H MRS study

Chronic exposure to low concentrations of strontium 90 affects bone physiology but not the hematopoietic system in mice

Early Differential Neurometabolite Response of Hippocampus on Exposure to Graded dose of Whole Body Radiation: An in Vivo 1H MR Spectroscopy Study

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Neuro-inflammatory response in rats chronically exposed to 137Cesium

Cited by 24 publications

References 30 publications

Altered brain metabolism after whole body irradiation in mice: A preliminary in vivo1H MRS study

Altered brain metabolism after whole body irradiation in mice: A preliminary in vivo1H MRS study

Chronic exposure to low concentrations of strontium 90 affects bone physiology but not the hematopoietic system in mice

Early Differential Neurometabolite Response of Hippocampus on Exposure to Graded dose of Whole Body Radiation: An in Vivo 1H MR Spectroscopy Study

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Altered brain metabolism after whole body irradiation in mice: A preliminary in vivo¹H MRS study

Altered brain metabolism after whole body irradiation in mice: A preliminary in vivo¹H MRS study