Neuro-nutraceutical potential of Asparagus racemosus: A review

Majumdar, Shreyasi; Gupta, Smriti; Prajapati, Santosh Kumar; Krishnamurthy, Sairam

doi:10.1016/j.neuint.2021.105013

Cited by 25 publications

(14 citation statements)

References 127 publications

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“…Neuro-nutraceutical potential of Asparagus racemosus: A review (Majumdar et al, 2021) Revisão integrativa da literatura Entender a maioria das descobertas neuro-baseadas de A. racemosus, sortidas em um lugar plausivelmente incitando para a futura elucidação das vias biomoleculares em interação por trás da atividade biológica observada do fitofármaco (A. racemosus).…”

Section: Potential Benefits Of Incorporatingunclassified

“…Assim, o extrato de A. racemosus diminuiu a AChE de maneira dose-dependente e, portanto, comprovando o efeito da planta no sistema colinérgico central (Ojha et al, 2010). Há também trabalhos ressaltando como a administração do extrato metanólico das raízes de A. racemosus pode inibir a monoamina oxidase (MAO) de maneira competitiva (Jagdish et al, 2015;Meena et al, 2011;Majumdar et al, 2021).…”

Section: Memória E Função Cognitivaunclassified

“…Não obstante, a teoria das monoaminas leva a crer que a depressão envolve um desequilíbrio no nível de neurotransmissores como a serotonina, dopamina e norepinefrina (Stahl, 2000), ainda que se saiba que a etiologia é altamente complexa (Majumdar et al, 2021).…”

Section: Efeito Antiestresseunclassified

“…Demonstrou-se também que extratos de A. racemosus diminuíram o aumento induzido pelo estresse na tribulina, um marcador endógeno de estresse (Bhattacharya et al, 2000;Majumdar et al, 2021).…”

Section: Efeito Antiestresseunclassified

“…Além disso, ratos pré-tratados com o extrato exibiram maiores contrações induzidas por 5-HTP do que o grupo controle destacando o aumento do nível de 5-HT extracelular em cérebros de roedores (Schreiber et al, 1995). Por isso, A. racemosus tem potencial para ser usado como um adaptógeno envolvendo o sistema serotoninérgico (Majumdar et al, 2021).…”

Section: Efeito Antiestresseunclassified

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Como os adaptógenos influenciam a performance cognitivo-mental: uma revisão integrativa

Zago

Negro-Dellacqua²

2022

RSD

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Dada a alta demanda pela otimização do desempenho pessoal em vários aspectos da vida social e, tendo em vista as prevalentes situações de estresse da vida moderna, foram aperfeiçoados os adaptógenos, termo cunhado em 1943 pelos russos. O objetivo deste estudo é analisar essas substâncias “tônicas” que aumentavam a performance física em soldados durante a II Guerra Mundial, e que adquiriram uma nova abordagem nos anos seguintes, tomando espaço significativo na melhora da performance cognitivo-mental. Para tal, o estudo, uma revisão integrativa da literatura, será baseado nas plataformas científicas Scientific Eletronic Library Online – SCIELO, Google Acadêmico, a U. S. National Library of Medicine (NLM) - PubMed e ScienceDirect. Espera-se encontrar correlação entre o uso de adaptógenos na melhora da resposta a eventos estressores, promovendo, por fim, a performance cognitivo-mental. Os estudos demonstram que os adaptógenos apresentam ações positivas na memória, na função cognitiva e neuroproteção; também demonstram efeito ansiolítico, nootrópico e antiestresse. Dentre as doenças, há evidências de que os adaptógenos possam ter benefício na Doença de Parkinson e na de Alzheimer. A Ashwagandha, especialmente, recebe destaque nos estudos. Uma limitação do presente trabalho, é que a maioria dos estudos recentes obtidos como resultados foram também apresentados na forma de revisão da literatura, deixando claro que há necessidades de novas evidências científicas. Mesmo assim, os resultados corroboram para novas pesquisas relacionadas com a compreensão das propriedades terapêuticas dos adaptógenos, com foco, principalmente, em estudos clínicos.

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Section: Potential Benefits Of Incorporatingunclassified

Section: Memória E Função Cognitivaunclassified

Section: Efeito Antiestresseunclassified

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Como os adaptógenos influenciam a performance cognitivo-mental: uma revisão integrativa

Zago

Negro-Dellacqua²

2022

RSD

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High‐performance thin‐layer chromatography coupled attenuated total reflectance‐Fourier‐transform infrared and NMR spectroscopy‐based identification of α‐amylase inhibitor from the aerial part of Asparagus racemosus Willd

Das

Ashraf

Baishya

et al. 2022

Phytochemical Analysis

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Introduction: α-Amylase inhibitors from natural sources are of interest for new drug development for the treatment of diabetes mellitus (DM). High-performance thinlayer chromatography (HPTLC) coupled bioassay guided isolation of bioactive compounds has been improved within last few years.Objective: A microchemical derivatised HPTLC-coupled attenuated total reflectance-Fourier-transform infrared (ATR-FTIR) and nuclear magnetic resonance (NMR) spectroscopy was employed for profiling α-amylase inhibitor from the aerial part of Asparagus racemosus Willd.Methodology: Asparagus racemosus Willd. aerial part extracted with different solvents (n-hexane, chloroform, ethyl acetate, and methanol) and assayed to detect free radical scavengers and α-amylase inhibitor by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and starch-iodine assay method, respectively. HPTLC-coupled ATR-FTIR and NMR spectroscopy was used to identify the α-amylase inhibitor.Results: Methanolic extract of A. racemosus showed highest antioxidant activity (21.99 μg GAE/μL) where n-hexane extract showed lowest antioxidant activity (5.87 μg GAE/μL). The α-amylase inhibition was recorded as highest and lowest in ethyl acetate extract (13.13 AE/μL) and n-hexane extract (3.92 AE/μL), respectively.The deep blue zone of α-amylase sprayed TLC plate of extracts with hR F = 72 analysed for ATR-FTIR and NMR spectroscopy which revealed the presence of stigmasterol is responsible for α-amylase inhibition. Conclusion:The present work establishes the α-amylase inhibiting properties of A. racemosus maintaining its use for the treatment of DM as a traditional medicine.Bioassay guided isolation through HPTLC-coupled ATR-FTIR and NMR spectroscopy offers an effective method for the exploration of bioactive compounds such as α-amylase inhibitor from complex plant extracts.

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Combining Network Pharmacology and Experimental Verification to Ascertain the Mechanism of Action of Asparagus officinalis Against the Brain Damage Caused by Fluorosis

Wang,

Liu,

et al. 2024

Environmental Toxicology

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Asparagus officinalis (ASP) has antioxidation, anti‐inflammatory, antiaging, and immune system‐enhancing effects. We explored the preventive and therapeutic consequences of ASP on the brain damage elicited by fluorosis through network pharmacology and in vivo experimental validation. We ascertained the pharmaceutically active ingredients and drug targets of ASP from the Traditional Chinese Medicine Systems Pharmacology database, predicted the disease targets of fluorosis‐induced brain injury using GeneCards and Online Mendelian Inheritance in Man databases, obtained target protein–protein interaction networks in the Search Tool for the Retrieval of Interacting Genes/Proteins database, used Cytoscape to obtain key targets and active ingredients, and conducted enrichment analyses of key targets in the Database for Annotation, Visualization and Integrated Discovery. Enrichment analyses showed that “mitogen‐activated protein kinase” (MAPK), “phosphoinositide 3‐kinase/protein kinase B” (PI3K‐Akt), “nuclear factor‐kappa B” (NF‐κB), and the “neurotrophin signaling pathway” were the most enriched biological processes and signaling pathways. ASP could alleviate fluorosis‐based injury, improve brain‐tissue damage, increase urinary fluoride content, and improve oxidation levels and inflammatory‐factor levels in the body. ASP could also reduce dental fluorosis, bone damage, fluoride concentrations in blood and bone, and accumulation of lipid peroxide. Upon ASP treatment, expression of silent information regulator (SIRT)1, brain‐derived neurotrophic factor (BDNF), tropomyosin receptor kinase B (TrkB), MAPK, NF‐κB, PI3K, Akt, and B‐cell lymphoma‐2 in rat brain tissue increased gradually, whereas that of Bax, caspase‐3, and p53 decreased gradually. We demonstrated that ASP could regulate the brain damage caused by fluorosis through the SIRT1/BDNF/TrkB signaling pathway, and reported the possible part played by ASP in preventing and treating fluorosis.

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Neuro-nutraceutical potential of Asparagus racemosus: A review

Cited by 25 publications

References 127 publications

Como os adaptógenos influenciam a performance cognitivo-mental: uma revisão integrativa

Como os adaptógenos influenciam a performance cognitivo-mental: uma revisão integrativa

High‐performance thin‐layer chromatography coupled attenuated total reflectance‐Fourier‐transform infrared and NMR spectroscopy‐based identification of α‐amylase inhibitor from the aerial part of Asparagus racemosus Willd

Combining Network Pharmacology and Experimental Verification to Ascertain the Mechanism of Action of Asparagus officinalis Against the Brain Damage Caused by Fluorosis

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