Neuro-ophthalmological Features of Cerebral Venous Sinus Thrombosis

Eliseeva, N M; Serova, N K; Yakovlev, S B; Mikeladze, K G; Gasparyan, S. A.

doi:10.3109/01658107.2014.953697

Cited by 13 publications

(9 citation statements)

References 19 publications

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“…Coutinho et al ( 2014 ) found that papilledema was more common in patients with cortical hemorrhage (44 vs. 9%) than in those without. Eliseeva et al ( 2015 ) conducted a retrospective case study of 49 patients diagnosed with CVT, including 15 who were acute (30.6%), 11 who were subacute (22.4%) and 23 who were chronic (47.0%). Papilledema was observed in 84.6% of the CVT patients with acute and subacute onset, and all patients with chronic onset had papilledema.…”

Section: Clinical Featuresmentioning

confidence: 99%

Diagnosis and Treatment of Cerebral Venous Thrombosis: A Review

Luo

Tian

Wang

2018

Front. Aging Neurosci.

128

145

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Cerebral venous thrombosis (CVT), also called cerebral venous sinus thrombosis (CVST), is a cerebrovascular disease with diverse clinical manifestations that often affects young adults, women of childbearing age, and children. It's most common clinical manifestations are headache, seizures, altered consciousness, and neurological focal signs on physical examination. CVT can manifest as a single symptom, or it can present as a syndrome consisting of multiple symptoms. This non-specific clinical picture makes diagnosing CVT difficult. Although the mortality rate of CVT has been significantly reduced by improvements in treatment and diagnostic techniques, the mortality rate of severe CVT remains as high as 34.2%. Survivors of this type of CVT have varying degrees of residual symptoms and are not able to return to their previous work. Hence, we performed a comprehensive literature search in the PubMed, EMBASE, and Medline databases to review the diagnosis and treatment of CVT.

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Section: Clinical Featuresmentioning

confidence: 99%

Diagnosis and Treatment of Cerebral Venous Thrombosis: A Review

Luo

Tian

Wang

2018

Front. Aging Neurosci.

128

145

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“…[ 5 ] It typically affects the superior sagittal and transverse sinus more frequently. [ 6 ] As CVT presents in various locations, its clinical manifestation also presents various symptoms depending on the location and mimics other disorders. Diagnosing CVT is challenging and takes an average of several days [ 7 ] owing to its low incidence and nonspecific symptoms, including headache, nausea, vomiting, and altered consciousness.…”

Section: Discussionmentioning

confidence: 99%

Homonymous hemianopia due to cerebral venous thrombosis: A case report

Choi,

Yoon,

Lee

2023

Medicine

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Rationale: Diagnosing cerebral venous thrombosis (CVT) can be difficult because of nonspecific symptoms, such as headache and homonymous hemianopia (HH). Herein, we present a case of delayed CVT diagnosis due to nonspecific neurological symptoms and nonprominent lesions in a patient with HH. Patient concern: A 65-year-old woman presented with a sudden onset headache accompanied by right HH that lasted for 1 day. Brain computed tomography and magnetic resonance imaging were initially performed due to suspicion of ischemic lesions or hemorrhage in the left postchiasmal visual pathway; however, no remarkable acute brain lesions were detected. Ophthalmological examinations revealed no notable findings, except for a definite field defect in the Humphrey visual field test. The headaches then waxed and waned but recurred 3 days after the initial symptom. A repeat brain magnetic resonance imaging was performed, which revealed left sectoral gyral swelling and vascular enhancement in the occipital lobe. To further evaluate venous drainage, additional 3-dimensional cerebral computed tomography angiography and 4-vessel angiography were conducted, revealing a partial filling defect in the left transverse sinus and superior venous drainage impairment. These findings suggested the presence of venous thrombosis in the left transverse sinus. Diagnosis: The patient was diagnosed with thrombosis of the left transverse sinus, which subsequently caused the right HH. Intervention: Anticoagulation therapy with parenteral heparin was started as soon as the diagnosis of CVT was confirmed. Eventually, the patient was solely managed with oral warfarin administration. Outcomes: Following 3 days of treatment, her headache resolved, and a subsequent visual field testing conducted 2 weeks later revealed a definite improvement in the field defect. Lessons: Despite its favorable prognosis, CVT can be challenging to diagnose. CVT should be considered as a differential diagnosis when diagnosing patients who present with headaches accompanied by HH without prominent brain lesions.

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“…DVST should be suspected in all patients with papilledema as it can present in a very similar manner to IIH as was seen in Case 1. 3,8 All cases of DVST should be investigated for an underlying hypercoagulable state, which is likely to be present in most patients. We found that only 2 out of 15 patients in our series (13%) had no identifiable prothrombotic factors.…”

Section: Discussionmentioning

confidence: 99%

Dural Venous Sinus Thrombosis and Papilledema Related to JAK2 Mutation: A Case Series

Donaldson

Dhoot

Margolin

2021

Can. J. Neurol. Sci.

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Background: Dural venous sinus thrombosis (DVST) is an important cause of papilledema. Patients diagnosed with DVST should undergo work-up for underlying hypercoagulable state, including genetic causes. One important prothrombotic mutation is in the JAK2 gene, which is a driver of myeloproliferative neoplasms including polycythemia vera (PV). We aimed to determine the prevalence of JAK2 mutation in patients in presenting to neuro-ophthalmology clinic with DVST and papilledema. Methods: Retrospective case series of patients seen in a tertiary neuro-ophthalmology practice who presented with papilledema due to DVST and were investigated for presence of JAK2 mutation. Results: Four out of 15 patients with DVST (26%) were found to have JAK2 V617F mutation which led to subsequent diagnosis of PV in 2. One additional patient had a known diagnosis of essential thrombocytosis. We describe the clinical presentation of these four patients with papilledema and JAK2 mutation. Conclusions: A significant proportion of patients with papilledema secondary to DVST will harbor mutations in the JAK2 gene. Clinicians should be aware of this mutation as early testing will facilitate timely diagnosis and treatment of myeloproliferative disease to improve prognosis and reduce risk of recurrent thrombotic events.

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Neuro-ophthalmological Features of Cerebral Venous Sinus Thrombosis

Cited by 13 publications

References 19 publications

Diagnosis and Treatment of Cerebral Venous Thrombosis: A Review

Diagnosis and Treatment of Cerebral Venous Thrombosis: A Review

Homonymous hemianopia due to cerebral venous thrombosis: A case report

Dural Venous Sinus Thrombosis and Papilledema Related to JAK2 Mutation: A Case Series

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