Neuro-ophthalmological findings in TAFRO syndrome in a patient from South America, a variant of multicentric Castleman’s disease

Abstract

The optic disk edema could be present as a neuro-ophthalmological finding in TAFRO syndrome. To the best of our knowledge, this is the first report on the ophthalmic manifestations in the TAFRO syndrome.

Severe refractory TAFRO syndrome requiring continuous renal replacement therapy complicated with Trichosporon asahii infection in the lungs and myocardial infarction: an autopsy case report and literature review

“…g After percutaneous old balloon angioplasty, reperfusion of blood flow is achieved treatment is recommended. Although ophthalmological findings of TAFRO syndrome have been rarely reported, Oritz et al first reported that optic disk edema could be an ophthalmological finding in TAFRO syndrome [30]. In addition to optic disk edema, Roth's spot was observed in the present case on fundus examination.…”

Validated international definition of the thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly clinical subtype (TAFRO) of idiopathic multicentric Castleman disease

“…Since it was first described, a number of cases of TAFRO syndrome have been reported worldwide. [2][3][4][5][6][7][8][9][10] This heterogeneous clinical entity can occur in the context of infectious diseases, malignancies, rheumatologic disorders, and idiopathic multicentric Castleman disease (iMCD). Multicentric Castleman disease (MCD) is a rare heterogenous systemic disorder characterized by systemic inflammation, multicentric lymphadenopathy with characteristic histopathological features, and organ dysfunction due to elevated pro-inflammatory cytokines including interleukin-6 (IL-6).…”

“…In 2010, Takai et al 1 first reported a series of cases exclusively in Japan with a constellation of non‐specific clinical symptoms, including thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis or renal insufficiency (R), and organomegaly (O). Since it was first described, a number of cases of TAFRO syndrome have been reported worldwide 2–10 . This heterogeneous clinical entity can occur in the context of infectious diseases, malignancies, rheumatologic disorders, and idiopathic multicentric Castleman disease (iMCD).…”

Comparison of the clinical characteristics of TAFRO syndrome and idiopathic multicentric Castleman disease in general internal medicine: a 6‐year retrospective study

“…8 Previously, MCD was considered to occur mainly in association with a human herpes virus 8 (HHV-8) infection in immunocompromised patients. [10][11][12][13] Although the clinical characteristics are similar in these two disorders, TAFRO syndrome has been described as a clinical entity distinct from iMCD because TAFRO syndrome is usually associated with hypogammaglobulinaemia, which is in stark contrast to iMCD, and with poor treatment response. 7 iMCD was thus further defined by HIV-and HHV-8-negative MCD subtypes.…”