Neuro-ophthalmological symptoms in patients with pineal and suprasellar germinoma

Serova, N K; Grigoreva, N.N.; Khavboshina, A.G.; Butenko, E.I.

doi:10.17116/oftalma202013604139

Cited by 2 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, we found that most of the cases in the HEV‐high group were female (Figure 4B). It has been reported that males took up the majority of pineal germinomas, while females prevailed in suprasellar ones 29,30 . In addition, the present study found more HEV‐high cases in suprasellar than in pineal germinomas.…”

Section: Discussionsupporting

confidence: 66%

“…It has been reported that males took up the majority of pineal germinomas, while females prevailed in suprasellar ones. 29 , 30 In addition, the present study found more HEV‐high cases in suprasellar than in pineal germinomas. Thus, it is possible that the disparity of HEVs distribution between genders is related to different tumor locations in male and female patients.…”

Section: Discussionsupporting

confidence: 65%

See 1 more Smart Citation

High endothelial venules in intracranial germinomas: Implications for lymphocytes infiltration

Chen

Cui

et al. 2022

Cancer Medicine

View full text Add to dashboard Cite

BackgroundReactive lymphocytes are substantial components of germinoma, which are believed to be related to the favorable prognosis of this intracranial tumor and better response to immunotherapy. However, the mechanisms managing the recruitment of lymphocytes are poorly understood. High endothelial venules (HEVs) are specialized blood vessels that play key roles in lymphocyte tra cking in Lymph nodes. These vessels are associated with lymphocytes in ltration in chronic in ammatory diseases and various malignant tumors, but their distribution and implications in germinoma are unknown. MethodsThis study investigated the presence and distribution of HEVs in 42 germinomas by immunohistochemical staining of peripheral node addressin (PNAd) and transmission electron microscopic examination. The correlation of the densities of HEVs with the extent of T and B lymphocytes in ltration and several clinicopathological characteristics were also analyzed to determine whether HEVs are responsible for lymphocytes recruitment and their roles in anti-tumor immunity in germinoma. ResultsPNAd-positive HEVs were detected in 31% (13/42) of germinomas, and their presence correlated with abundant in ltrating CD3 + T cells, CD20 + B cells and CD8 + Cytotoxic T Lymphocytes (p = 0.0410, 0.0023, 0.0061, respectively). Higher HEVs density was also correlated with several clinicopathological parameters, which are recognized indicators for favorable prognosis in germinomas, including typical tumor location (p = 0.0093), lower tumor cell content (P = 0.0428), and younger age at diagnosis (p = 0.0121). Furthermore, bioinformatics analysis showed HEVs-associated genes mainly enriched in immune-related Gene Ontology terms, including innate immune response, in ammatory response, and B cell receptor signaling pathway. The xCell analysis revealed that germinomas with higher HEVs enrichment scores had increased levels of the immune score, microenvironment score, dendritic cells, CD8 + central memory T-cells, CD4 + memory T-cells, and B-cells. ConclusionOur ndings indicate that HEVs could contribute to lymphocytes recruitment in germinomas, thus may serve as a predictor of favorable prognosis and better response to immunotherapy in this intracranial tumor.

show abstract

Section: Discussionsupporting

confidence: 66%

Section: Discussionsupporting

confidence: 65%

High endothelial venules in intracranial germinomas: Implications for lymphocytes infiltration

Chen

Cui

et al. 2022

Cancer Medicine

View full text Add to dashboard Cite

show abstract

“…These 24 neuroophthalmological symptoms tend to manifest in early stages of disease and require ophthalmological exam at all stages of diagnosis and treatment. 25 …”

Section: Diagnosismentioning

confidence: 99%

“…These field deficits are often asymmetric. 25 , 28 Unilateral blindness and loss of the papillomacular bundle from tumor cells seeding the optic nerve sheath and/or infiltrating the optic nerve can occur. 29 This seeding may occur in a delayed manner and has been observed to occur as long as 12 years after initial diagnosis.…”

Section: Diagnosismentioning

confidence: 99%

“… 27 , 31 Up to 75% patients may have Parinaud’s Syndrome. 25 The most characteristic sign is supranuclear palsy of conjugate upward gaze when eyes are straight in primary position, as seen in 69.7% of patients. 32 Compared to other pineal tumors, up-gaze paresis is more common in germinoma because the pattern by which germinoma grows near the midbrain compresses or infiltrates the vertical gaze centers near the superior colliculus, including the interstitial nucleus of Cajal and the rostral interstitial nucleus of the medial longitudinal fasciculus (riMFL).…”

Section: Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

Diagnosis and Management of Pineal Germinoma: From Eye to Brain

Cohen¹,

Litofsky²

2023

View full text Add to dashboard Cite

Pineal germinomas can be very complex in terms of presentation, diagnosis, and management. This review attempts to simplify this complexity in an organized manner, addressing the anatomic relationships that provide the basis for the uniqueness of pineal germinoma. Ocular findings and signs and symptoms of elevated intracranial pressure are the keys to suspecting the diagnosis and obtaining the necessary imaging and cerebrospinal fluid studies. Other symptoms can suggest spread beyond the pineal region. Surgery may only be needed to obtain tissue for a definitive diagnosis, as germinoma is highly responsive to chemotherapy and focused radiation therapy. Hydrocephalus, usually related to tumor obstruction of the cerebral aqueduct, may also need to be addressed. Outcome for pineal germinoma is usually excellent, but relapse can occur and may require additional intervention. These issues are detailed in this review.

show abstract

Neuro-ophthalmological symptoms in patients with pineal and suprasellar germinoma

Cited by 2 publications

References 14 publications

High endothelial venules in intracranial germinomas: Implications for lymphocytes infiltration

High endothelial venules in intracranial germinomas: Implications for lymphocytes infiltration

Diagnosis and Management of Pineal Germinoma: From Eye to Brain

Contact Info

Product

Resources

About