Neuro-orchestration of sleep and wakefulness

Sulaman, Bibi A.; Wang, Su; Tyan, Jean; Eban-Rothschild, Ada

doi:10.1038/s41593-022-01236-w

Cited by 49 publications

(46 citation statements)

References 151 publications

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“…While some have suggested that the lower sleeping Tb is due to a failure or ‘suspension of thermoregulation’ [ 59 ], most agree that the lower Tb is a regulated process, which our results strongly support. Defended Tbs are context dependent, being higher during fever [ 60 ] and lower during torpor [ 61 ].…”

Section: Discussionsupporting

confidence: 83%

Beyond day and night: The importance of ultradian rhythms in mouse physiology

Škop,

Liu,

Xiao

et al. 2024

Molecular Metabolism

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Section: Discussionsupporting

confidence: 83%

Beyond day and night: The importance of ultradian rhythms in mouse physiology

Škop,

Liu,

Xiao

et al. 2024

Molecular Metabolism

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“…To examine how noradrenergic signaling modulates arousal states via downstream effector regions, we chose two projections of LC NE neurons to well-known wake-promoting structures, one to the posterior basal forebrain (BF) and the other to the medial thalamus (Thal) 19,20 . As shown in LC NE tonic frequency typically ranges from 1-6Hz 12,21 , though it has been shown to go up to ~8-10Hz with significant stress 22,23 .…”

Section: Resultsmentioning

confidence: 99%

Activity-dependent constraints on catecholamine signaling

Rana

et al. 2023

Preprint

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Catecholamine signaling is thought to modulate cognition in an inverted-U relationship, but the mechanisms are unclear. We measured norepinephrine and dopamine release, postsynaptic calcium responses, and interactions between tonic and phasic firing modes under various stimuli and conditions. High tonic activity in vivo depleted catecholamine stores, desensitized postsynaptic responses, and decreased phasic transmission. Together this provides a clearer understanding of the inverted-U relationship, offering insights into psychiatric disorders and neurodegenerative diseases with impaired catecholamine signaling.

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“…The hypothalamic orexin/hypocretin neurons are indispensable for sleep/wakefulness regulation [ 5 ]. It has been found that loss of these neurons leads to a fairly wide range of abnormalities in sleep/wakefulness behaviors [ 3 , 6 ]. Chief among them are deficits related to dysregulation of wakefulness state or rapid eye movement (REM) sleep, including excessive daytime sleepiness, frequent sleep–wakefulness transitions, cataplexy, vivid hallucinations, sleep paralysis, REM sleep behavior disorder (RBD), and sleep onset REM (SOREM) sleep [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Orexin Neurons to Sublaterodorsal Tegmental Nucleus Pathway Prevents Sleep Onset REM Sleep-Like Behavior by Relieving the REM Sleep Pressure

Feng,

Qiao,

Luo

et al. 2024

Research

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Proper timing of vigilance states serves fundamental brain functions. Although disturbance of sleep onset rapid eye movement (SOREM) sleep is frequently reported after orexin deficiency, their causal relationship still remains elusive. Here, we further study a specific subgroup of orexin neurons with convergent projection to the REM sleep promoting sublaterodorsal tegmental nucleus (OX SLD neurons). Intriguingly, although OX SLD and other projection-labeled orexin neurons exhibit similar activity dynamics during REM sleep, only the activation level of OX SLD neurons exhibits a significant positive correlation with the post-inter-REM sleep interval duration, revealing an essential role for the orexin-sublaterodorsal tegmental nucleus (SLD) neural pathway in relieving REM sleep pressure. Monosynaptic tracing reveals that multiple inputs may help shape this REM sleep-related dynamics of OX SLD neurons. Genetic ablation further shows that the homeostatic architecture of sleep/wakefulness cycles, especially avoidance of SOREM sleep-like transition, is dependent on this activity. A positive correlation between the SOREM sleep occurrence probability and depression states of narcoleptic patients further demonstrates the possible significance of the orexin-SLD pathway on REM sleep homeostasis.

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Neuro-orchestration of sleep and wakefulness

Cited by 49 publications

References 151 publications

Beyond day and night: The importance of ultradian rhythms in mouse physiology

Beyond day and night: The importance of ultradian rhythms in mouse physiology

Activity-dependent constraints on catecholamine signaling

Orexin Neurons to Sublaterodorsal Tegmental Nucleus Pathway Prevents Sleep Onset REM Sleep-Like Behavior by Relieving the REM Sleep Pressure

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