2023
DOI: 10.3390/biom13091325
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Neuroactive Steroid–Gut Microbiota Interaction in T2DM Diabetic Encephalopathy

Silvia Diviccaro,
Lucia Cioffi,
Rocco Piazza
et al.

Abstract: The pathological consequences of type 2 diabetes mellitus (T2DM) also involve the central nervous system; indeed, T2DM patients suffer from learning and memory disabilities with a higher risk of developing dementia. Although several factors have been proposed as possible contributors, how neuroactive steroids and the gut microbiome impact brain pathophysiology in T2DM remain unexplored. On this basis, in male Zucker diabetic fatty (ZDF) rats, we studied whether T2DM alters memory abilities using the novel obje… Show more

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