Neuroactive Steroids, Relaxation, and Seizure Control

Wiener, Patricia

doi:10.1080/00207450390200080

Cited by 10 publications

(4 citation statements)

References 29 publications

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“…and gonads, which easily cross the blood-brain barrier and act as neuroactive steroids (6)(7)(8). These effects on neuron excitability are due to modulatory activity, either direct or mediated by steroid metabolites, on a variety of neurotransmitter receptors [e.g., γ -aminobutyric acid A (GABA A ) and N-methyl-D-aspartate (NMDA)] and/or ion channels on the cell membranes, involved in stress response, epileptogenesis, and seizure occurrence (7)(8)(9)(10)(11).…”

mentioning

confidence: 99%

Seizure Frequency and Cortisol and Dehydroepiandrosterone Sulfate (DHEAS) Levels in Women with Epilepsy Receiving Antiepileptic Drug Treatment

Galimberti

Magri

Copello³

et al. 2005

Epilepsia

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Summary:Purpose: Hormonal changes occur in epilepsy because of seizures themselves and of antiepileptic drug (AED) effects on steroid production, binding, and metabolism. Conversely, steroids may influence neuron activity and excitability by acting as neuroactive steroids. This cross-sectional observational study aimed to evaluating cortisol and dehydroepiandrosterone sulfate (DHEAS) levels in female epilepsy patients with different disease severity, as assessed by a seizure frequency score (SFS).Methods: Morning serum levels of cortisol and DHEAS were assayed in 113 consecutive women, aged 16 to 47 years, with varied epilepsy syndromes, receiving mono-or polytherapy with enzyme-inducing and/or noninducing antiepileptic drugs (AEDs). Hormonal data were correlated with clinical parameters (age, body mass index, epilepsy syndrome, disease onset and duration, SFS, AED therapy, and AED serum levels) and compared with those of 30 age-matched healthy women. Results:In epilepsy patients, cortisol levels and cortisolto-DHEAS ratios (C/Dr) were significantly higher, whereas DHEAS levels were significantly lower than those in controls. Patients with more frequent seizures showed higher cortisol and C/Dr values and lower DHEAS levels than did those with rarer or absent seizures during the previous 6 months. SFS mainly explained the increase of cortisol levels and C/Dr in patients with more active disease. Changes in DHEAS levels correlated with SFS and epilepsy syndrome, as well as with AED treatments and ages.Conclusions: Women with more frequent seizures had alterations of their adrenal steroids characterized by an increase of cortisol and a decrease of DHEAS levels. Such hormonal changes might be relevant in seizure control and in patient health.

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confidence: 99%

Seizure Frequency and Cortisol and Dehydroepiandrosterone Sulfate (DHEAS) Levels in Women with Epilepsy Receiving Antiepileptic Drug Treatment

Galimberti

Magri

Copello³

et al. 2005

Epilepsia

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“…These steroids are related to sex hormones, which in contrast to testosterone and corticosteroids, are recognised to have weak proconvulsant (oestrogen) and more importantly, anticonvulsant (progesterone and its metabolites) effects. [61][62][63][64] One of these drugs, ganaxolone-an ''epalon'', a shortened form of epiallopregnanolone 64 -has been shown to be effective in treating partial seizures and IS, and without the potentially severe side effects associated with ACTH and prednisolone. Further data are clearly required to assess not only the effectiveness but also, and arguably more importantly, the relative efficacy of this potentially less ''toxic'' and more specific neuroactive steroid, compared to prednisolone, ACTH, or hydrocortisone.…”

Section: Mechanism Of Action Of Corticosteroidsmentioning

confidence: 99%

Bronchial artery to bronchial vein fistula secondary to lung nodule resection

McHugh

Hegde²,

Brock³

et al. 2005

Archives of Disease in Childhood

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“…The extent to which stress can affect the CNS neurochemically by the action of neuroactive steroids, and thereby moderate the onset and intensity of seizures continues to be studied (Wiener 2002). Stress has been linked to interfere with endocrine and immune functions (Bauer et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Neurotherapy in Adult Management of Stress: Developmental Aspects of the Adult Immune System

Wiener¹

2011

J Adult Dev

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Stress, defined as a stimulus, a response, and an interaction between the person and the environment is eventually present in everyday life. Nevertheless, stress can be both dangerous and uncomfortable. Stress influences the corticotropin-releasing factor and the locus ceruleusnorepinephrine systems, which in turn impact the hypothalamic-pituitary-adrenal axis and the autonomic nervous system. At the same time, stress directly affects the immune system. Treatment by means of an alternative approach such as neurotherapy can enhance the immune system and thereby improve the patient's overall wellbeing.

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Neuroactive Steroids, Relaxation, and Seizure Control

Cited by 10 publications

References 29 publications

Seizure Frequency and Cortisol and Dehydroepiandrosterone Sulfate (DHEAS) Levels in Women with Epilepsy Receiving Antiepileptic Drug Treatment

Seizure Frequency and Cortisol and Dehydroepiandrosterone Sulfate (DHEAS) Levels in Women with Epilepsy Receiving Antiepileptic Drug Treatment

Bronchial artery to bronchial vein fistula secondary to lung nodule resection

Neurotherapy in Adult Management of Stress: Developmental Aspects of the Adult Immune System

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