Neuroadhesive protein coating improves the chronic performance of neuroelectronics in mouse brain

Golabchi, Asiyeh; Woeppel, Kevin; Li, Xia; Lagenaur, Carl F.; Cui, Xiufang

doi:10.1016/j.bios.2020.112096

Cited by 50 publications

(50 citation statements)

References 82 publications

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“…Likewise, the neuronal distribution was slightly more pronounced at superficial depths as well. While these findings are preliminary, our observations are consistent with previous studies that examined the foreign body response of silicon-based probes [22,27,28], where superficial depths tend to show a more pronounced immunohistological response than deeper regions. Since the MS microelectrode sites are located within deeper regions in the cortex when implanted, the loss of activity may not be entirely related to a local tissue response.…”

Section: Resultssupporting

confidence: 92%

Influence of Implantation Depth on the Performance of Intracortical Probe Recording Sites

et al. 2021

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Microelectrode arrays (MEAs) enable the recording of electrical activity from cortical neurons which has implications for basic neuroscience and neuroprosthetic applications. The design space for MEA technology is extremely wide where devices may vary with respect to the number of monolithic shanks as well as placement of microelectrode sites. In the present study, we examine the differences in recording ability between two different MEA configurations: single shank (SS) and multi-shank (MS), both of which consist of 16 recording sites implanted in the rat motor cortex. We observed a significant difference in the proportion of active microelectrode sites over the 8-week indwelling period, in which SS devices exhibited a consistent ability to record activity, in contrast to the MS arrays which showed a marked decrease in activity within 2 weeks post-implantation. Furthermore, this difference was revealed to be dependent on the depth at which the microelectrode sites were located and may be mediated by anatomical heterogeneity, as well as the distribution of inhibitory neurons within the cortical layers. Our results indicate that the implantation depth of microelectrodes within the cortex needs to be considered relative to the chronic performance characterization.

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Section: Resultssupporting

confidence: 92%

Influence of Implantation Depth on the Performance of Intracortical Probe Recording Sites

et al. 2021

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“…[ 30,31,58,59 ] The axonal promoting effect of L1 coating on neural probe has been previously reported by our group. [ 11,33,60 ] The result here is consistent with the previous finding.…”

Section: Discussionsupporting

confidence: 93%

“…[ 29–32 ] When bound to the neural electrode, L1 decreases microglia activation and astrogliosis, increases the number of neurons adjacent to the electrode, and improves electrophysiological recording for up to 16 weeks. [ 11,29,33–35 ] While highly promising, bioactive coatings may have limitations stemming from their limited bioactive lifetimes and their binding being limited to the surface area of the electrode.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle and Biomolecule Surface Modification Synergistically Increases Neural Electrode Recording Yield and Minimizes Inflammatory Host Response

Woeppel

Cui

2021

Adv Healthcare Materials

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Due to their ability to interface with neural tissues, neural electrodes are the key tool used for neurophysiological studies, electrochemical detection, brain computer interfacing, and countless neuromodulation therapies and diagnostic procedures. However, the long‐term applications of neural electrodes are limited by the inflammatory host tissue response, decreasing detectable electrical signals, and insulating the device from the native environment. Surface modification methods are proposed to limit these detrimental responses but each has their own limitations. Here, a combinatorial approach is presented toward creating a stable interface between the electrode and host tissues. First, a thiolated nanoparticle (TNP) coating is utilized to increase the surface area and roughness. Next, the neural adhesion molecule L1 is immobilized to the nanoparticle modified substrate. In vitro, the combined nanotopographical and bioactive modifications (TNP+L1) elevate the bioactivity of L1, which is maintained for 28 d. In vivo, TNP+L1 modification improves the recording performance of the neural electrode arrays compared to TNP or L1 modification alone. Postmortem histology reveals greater neural cell density around the TNP+L1 coating while eliminating any inflammatory microglial encapsulation after 4 weeks. These results demonstrate that nanotopographical and bioactive modifications synergistically produce a seamless neural tissue interface for chronic neural implants.

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“…The curve resulted in an initial AEY value of ~75% and slope of –2.2 percent/week with adjusted R 2 and Pearson’s R values of 0.67 and –0.83 respectively. Data used to create Figure 3 was extrapolated from the references as follows: Custom [ 16 , 30 , 32 , 51 , 52 , 55 , 61 , 62 , 71 , 84 , 88 , 92 ], Microwire [ 58 , 63 , 81 , 82 ], Neuronexus [ 24 , 25 , 26 , 27 , 44 , 68 , 91 ], Blackrock [ 29 , 98 , 99 , 103 ].…”

Section: Figurementioning

confidence: 99%

Intracortical Microelectrode Array Unit Yield under Chronic Conditions: A Comparative Evaluation

et al. 2021

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While microelectrode arrays (MEAs) offer the promise of elucidating functional neural circuitry and serve as the basis for a cortical neuroprosthesis, the challenge of designing and demonstrating chronically reliable technology remains. Numerous studies report “chronic” data but the actual time spans and performance measures corresponding to the experimental work vary. In this study, we reviewed the experimental durations that constitute chronic studies across a range of MEA types and animal species to gain an understanding of the widespread variability in reported study duration. For rodents, which are the most commonly used animal model in chronic studies, we examined active electrode yield (AEY) for different array types as a means to contextualize the study duration variance, as well as investigate and interpret the performance of custom devices in comparison to conventional MEAs. We observed wide-spread variance within species for the chronic implantation period and an AEY that decayed linearly in rodent models that implanted commercially-available devices. These observations provide a benchmark for comparing the performance of new technologies and highlight the need for consistency in chronic MEA studies. Additionally, to fully derive performance under chronic conditions, the duration of abiotic failure modes, biological processes induced by indwelling probes, and intended application of the device are key determinants.

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Neuroadhesive protein coating improves the chronic performance of neuroelectronics in mouse brain

Cited by 50 publications

References 82 publications

Influence of Implantation Depth on the Performance of Intracortical Probe Recording Sites

Influence of Implantation Depth on the Performance of Intracortical Probe Recording Sites

Nanoparticle and Biomolecule Surface Modification Synergistically Increases Neural Electrode Recording Yield and Minimizes Inflammatory Host Response

Intracortical Microelectrode Array Unit Yield under Chronic Conditions: A Comparative Evaluation

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