Neuroanatomical changes of the medial prefrontal cortex of male pups of Wistar rat after prenatal and postnatal noise stress

Teimouri, Mahtab; Heidari, Mohammad Hassan; Amini, Abdollah; Sadeghi, Yousef; Abdollahifar, Mohammad‐Amin; Aliaghaei, Abbas; Khavanin, Ali; Nadri, Farshad; Danyali, Samira; Sanchooli, Tayebeh

doi:10.1016/j.acthis.2020.151589

Cited by 10 publications

(5 citation statements)

References 30 publications

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“…5-HT decreases glutamatergic synaptic strength by activating 5-HT 1A , 5-HT 2A , and 5-HT 7 receptors in PFC slices from P14-16 animals. This is consistent with gene expression and electrophysiological studies, showing that these receptors are highly expressed in PFC pyramidal cells between the second and third week of the postnatal period 29 , 33 , 41 – 45 . This is also consistent with other studies reporting that 5-HT 1A , 5-HT 2A , and 5-HT 7 receptors stimulation directly depress PFC synapses 32 , 33 , 45 , 46 .…”

Section: Discussionsupporting

confidence: 90%

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5-HT-dependent synaptic plasticity of the prefrontal cortex in postnatal development

Higa

Oliveira

Carlos-Lima

et al. 2022

Sci Rep

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Important functions of the prefrontal cortex (PFC) are established during early life, when neurons exhibit enhanced synaptic plasticity and synaptogenesis. This developmental stage drives the organization of cortical connectivity, responsible for establishing behavioral patterns. Serotonin (5-HT) emerges among the most significant factors that modulate brain activity during postnatal development. In the PFC, activated 5-HT receptors modify neuronal excitability and interact with intracellular signaling involved in synaptic modifications, thus suggesting that 5-HT might participate in early postnatal plasticity. To test this hypothesis, we employed intracellular electrophysiological recordings of PFC layer 5 neurons to study the modulatory effects of 5-HT on plasticity induced by theta-burst stimulation (TBS) in two postnatal periods of rats. Our results indicate that 5-HT is essential for TBS to result in synaptic changes during the third postnatal week, but not later. TBS coupled with 5-HT2A or 5-HT1A and 5-HT7 receptors stimulation leads to long-term depression (LTD). On the other hand, TBS and synergic activation of 5-HT1A, 5-HT2A, and 5-HT7 receptors lead to long-term potentiation (LTP). Finally, we also show that 5-HT dependent synaptic plasticity of the PFC is impaired in animals that are exposed to early-life chronic stress.

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Section: Discussionsupporting

confidence: 90%

“…to chronic stress in the postnatal period [37][38][39][40][41] . Maternal separation (MS) impairs 5-HT modulation of PFC activity during the early life and these effects cause behavioral modifications that persist until adult life 35 .…”

Section: -Ht Fails To Facilitate Synaptic Plasticity In Ms Animals Th...mentioning

confidence: 99%

5-HT-dependent synaptic plasticity of the prefrontal cortex in postnatal development

Higa

Oliveira

Carlos-Lima

et al. 2022

Sci Rep

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“…Our results, by highlighting the signi cance of the prenatal and early postnatal period, show that minor in ammation during the critical period before birth in conjunction with stress in the early days after birth could be detrimental to PFC myelination. This extensive destruction could be associated with abnormalities in various brain functions in adulthood (Tottenham 2013;Teimouri et al 2020).…”

Section: Discussionmentioning

confidence: 99%

“…The prefrontal cortex (PFC), one of the most critical brain regions involved in behavioral exibility, plays an important role in control of anxiety and stress. In addition, the integrity of the myelin structure in this area is of utmost importance for accurate functioning of neural circuits in the brain (Hoban et al 2016;Noshadian et al 2020;Teimouri et al 2020). Myelin in the CNS is produced by oligodendrocytes, and it is a continuous process that starts during prenatal development and continues during the postnatal period (Bradl and Lassmann 2010;Soomro et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Prepubertal Stress Following Mild Maternal Immune System Activation Damages Prefrontal White MatterStructure and Related Molecules in Adult Mice Offspring

Namvarpour¹,

Ranaei²,

Amini³

et al. 2021

Preprint

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Mild maternal immune activation (MIA) by inflammatory agents such as lipopolysaccharide (LPS) and prepubertal stress (PS) may individually and collectively affect the central nervous system (CNS) during adulthood. Here, we intend to assess the effects of mild MIA, alone or combined with PS, on prefrontal white matter structure and its related molecules in adult mice offspring. Pregnant mice received either a mild intraperitoneal (IP) dose of LPS (50 μg/kg) on gestational day 17 (GD17) or normal saline. Their pups were exposed to stress from postnatal days (PD) 30 to PD38 or no stress during prepubertal development. We randomly chose 56-day-old male offspring (n=2 offspring per mother) from each group and isolated their prefrontal areas according to relevant protocols. The tissue samples were prepared for structural, histological, and molecular examinations. According to the results, the LPS+stress group had evidence of increased damage in the white matter structures compared to the control, stress, and LPS groups (p<.05). The LPS+stress group also had significant downregulation of the genes involved in white matter formation (Sox10, Olig1, myelin regulatory factor (Aprato et al), and Wnt) compared to the control, stress, and LPS groups (p<.05).In conclusion, although each manipulation individually resulted in small changes in myelination, their combined effects were more pronounced. These changes were parallel to abnormal expression levels of the molecular factors that contribute to myelination.

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“…Water and food were withheld during the experiment. Scoring was given when the rat buried two-thirds of a marbles surface into the bedding material [41].…”

Section: Marble-burying Behavior Testmentioning

confidence: 99%

Impacts of Maternal Noise Exposure on Risk of Stillbirth and Oxidative Stress-Induced Neurobehavioral Changes in Offspring

2023

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Life does not start at birth but at conception. Embryonic development is a particularly difficult period in which genetic and environmental factors can interact to contribute to risk. In utero and early neonatal exposure to maternal stress are linked with psychiatric disorders, and the underlying mechanisms are currently being elucidated. This study examined novel relationships between maternal noise exposure causing oxidative-stress-induced neurobehavioral changes in cognition and autism spectrum disorder (ASD) in offspring. Pregnant Wistar albino rats were exposed to noise (100 dBA/4 h). There were three groups of pregnant rats exposed to noise during gestation, as well as a control group: early gestational stress (EGS), which occurs between the 1st and 10th days of pregnancy; late gestational stress (LGS), which occurs between the 11th day and the delivery day; and full-term gestational stress (FGS), which occurs during the entire pregnancy period. Maternal stress effects on the offspring were analyzed. This study observed that noise exposure becomes a psychosocial stressor in the prenatal period of motherhood. In the EGS and LGS groups, female rats showed continuous midterm abortion and stillbirth during noise exposure. The noise-exposed group exhibited significant changes in cognition, obsessive–compulsive behavior, fear, and anxiety. Corticosterone and oxidative stress markers increased, and the antioxidant level was significantly decreased in the noise-exposed group. Therefore, maternal noise exposure causes recurrent abortions and stillbirths, increases oxidative stress, and impairs the offspring’s neurodevelopment.

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Neuroanatomical changes of the medial prefrontal cortex of male pups of Wistar rat after prenatal and postnatal noise stress

Cited by 10 publications

References 30 publications

5-HT-dependent synaptic plasticity of the prefrontal cortex in postnatal development

5-HT-dependent synaptic plasticity of the prefrontal cortex in postnatal development

Prepubertal Stress Following Mild Maternal Immune System Activation Damages Prefrontal White MatterStructure and Related Molecules in Adult Mice Offspring

Impacts of Maternal Noise Exposure on Risk of Stillbirth and Oxidative Stress-Induced Neurobehavioral Changes in Offspring

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