Neuroanatomical correlates of cognitive aging: Evidence from structural magnetic resonance imaging.

Raz, Naftali; Gunning-Dixon, Faith M.; Head, Denise; Dupuis, James H.; Acker, James D.

doi:10.1037/0894-4105.12.1.95

Cited by 476 publications

(412 citation statements)

References 136 publications

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“…The egocentricity of older adults reflects the default position of a general self-prioritizing processing bias. In line with the decline in cognitive flexibility in this age group, however (e.g., Dempster, 1992;Raz, Gunning-Dixon, Head, Dupuis, & Acker, 1998;van der Linden, Brédart, & Beerten, 1994), they were less able than the younger group to suppress self-bias when it interfered with task performance.…”

Section: Flexibility Of Self-biasesmentioning

confidence: 78%

Editorial: A Review of Self-Processing Biases in Cognition

Cunningham

Turk

2017

Quarterly Journal of Experimental Psychology

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Section: Flexibility Of Self-biasesmentioning

confidence: 78%

Editorial: A Review of Self-Processing Biases in Cognition

Cunningham

Turk

2017

Quarterly Journal of Experimental Psychology

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“…Rates are highest among the young (17% for ages 18-29), considerably less in middle age (4% for ages 30-59), and virtually non-existent in those over 60 (Miller 1991). While such figures may represent the "wisdom" commonly associated with aging, they may also reflect age-related brain changes (Bartzokis et al 2000;Coffey et al 1992;Gottfries et al 1983;Jernigan et al 1990;Lepage et al 1985;Lim et al 1992;Matsumae et al 1996;Pfefferbaum et al 1994;Raz et al 1998;Sullivan et al 1995;Wahlund et al 1990;Wang et al 1996), which alter the balance between the addicting versus the aversive effects of cocaine by diminishing the euphoric experience of drug intoxication. Consequently, the tendency to develop a dependence syndrome decreases and the capacity to discontinue use increases (Miller 1991;Cook and Harrell 1987;Facy et al 1991;Bartzokis et al 1999b,c).…”

Section: Discussionmentioning

confidence: 99%

Increased CSF Volumes Are Associated with Diminished Subjective Responses to Cocaine Infusion

Bartzokis

Beckson

et al. 2000

Neuropsychopharmacology

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We evaluated the hypothesis that ventricular and cortical CSF volume increases are associated with reductions in the magnitude of euphoric effects produced by intravenous IV cocaine infusion in cocaine dependent (CD) individuals. Eleven CD patients participating in a cocaine-infusion study and eleven control subjects underwent magnetic resonance imaging (MRI). Two CSF regions of interest (lateral ventricles and frontal cortex CSF) and two comparison regions (third ventricle and posterior cortex CSF) were measured. Self-reported ratings of the intensity of euphoric response ("high") were obtained from the CD subjects at 3, 10, and 30 minutes after IV administration of cocaine. A significant negative correlation was observed between the volume of the lateral ventricles and subjective ratings of the "high" experienced at 3 minutes, but not at 10 The relationship between brain variables and subjective effects of cocaine has not been extensively studied. Morgan et al. (1993), using non-contrast computerized tomography (CT), examined the association between ventricular brain ratio (VBR) and intensity of response to the effects of 40 mg of intravenous cocaine. They obtained subjective ratings of drug effect every minute for 30 minutes after the cocaine injection and observed a significant negative correlation (r ϭ Ϫ .53, p ϭ .02) between VBR and the average rating of drug response over the first 10 minute interval but no relationship over the last two 10 minute intervals (r ϭ Ϫ .22 and r ϭ (Morgan et al. 1993). This suggested that subjects with larger ventricles had reduced sensitivity to cocaine's immediate euphoric effects.As part of a recent study investigating the possible attenuating effects of selegiline on cocaine-induced euphoria and brain metabolism (Bartzokis et al. 1999a), non-treatment seeking "crack" cocaine smokers were evaluated with magnetic resonance imaging (MRI) of the brain in order to identify patients with enlarged ventricles who may be less responsive to IV cocaine's euphoric effects. The total volume of the lateral ventricles was measured in order to evaluate the magnitude of the negative association between this volume measure and the experience of euphoria ("high") associated with cocaine infusion. The volume of the third ventricle was also measured in order to assess whether this structure/function association was specific to the lateral ventricles or a phenomenon associated with generalized ventriculomegaly.In addition, the volume of the supracortical cerebrospinal fluid (CSF) in the frontal region of the cerebral cortex was measured in order to indirectly assess whether reduced frontal cortex gray matter observed in the polysubstance dependent (Liu et al. 1998) and alcohol dependent (Pfefferbaum et al. 1998) populations is also associated with a diminished intensity of cocaine infusion-induced euphoria. As with the ventricular volumes, we hypothesized that the volume of CSF in this cortical region will also correlate negatively to the cocaine infusion-associated experience of euphoria...

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“…In two other studies with subjects aged 18 to 80 years no relation could be established between brain volumes and neuropsychological test results after controlling for the effects of age [22,32]. However, in studies where only 55ϩ subjects were included a significant relation was found between limbic structures and memory test performance [13,14,32].…”

Section: Relation Between Brain Volumes and Cognitive Performancementioning

confidence: 92%

“…Only two studies have investigated the relation between regional brain atrophy and cognitive deterioration using quantitative (i.e. volumetric) analysis methods in a large sample [14,32]. A relation was found between limbic structures and memory in subjects over 55 years of age.…”

Section: Introductionmentioning

confidence: 99%

The relation between global and limbic brain volumes on MRI and cognitive performance in healthy individuals across the age range

Tisserand

Visser

Boxtel

et al. 2000

Neurobiology of Aging

118

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The present study investigated the range of age-related changes in brain morphology and the relation with performance on memory and other cognitive tests in a healthy population. A group of 61 subjects (21 to 81 years old, mean ϭ 55.7), free from cognitive and medical deficits, underwent MRI scanning and neuropsychological assessment encompassing memory and other cognitive tests. Volumetry of the hippocampus, parahippocampal gyrus, mamillary bodies, third ventricle, and total brain matter was performed. The results indicate that in healthy individuals increases in ventricular volume and volume decreases in total brain matter, hippocampus and parahippocampal gyrus, but not mamillary bodies, are clearly apparent with increasing age. However, no relation could be established between the brain volumes and test performance when controlling for the effects of age. To conclude, variations in total and limbic brain volumes do not seem predictive for cognitive performance independent of age.

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Neuroanatomical correlates of cognitive aging: Evidence from structural magnetic resonance imaging.

Cited by 476 publications

References 136 publications

Editorial: A Review of Self-Processing Biases in Cognition

Editorial: A Review of Self-Processing Biases in Cognition

Increased CSF Volumes Are Associated with Diminished Subjective Responses to Cocaine Infusion

The relation between global and limbic brain volumes on MRI and cognitive performance in healthy individuals across the age range

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