Neuroanatomical identification of the frog habenular connections using peroxidase (HRP)

Kemali, Milena; Guglielmotti, Vittorio; Gioffrè, Domenico

doi:10.1007/bf00236654

Cited by 49 publications

(42 citation statements)

References 22 publications

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“…These cells were few but consistently present in Taricha brains. The IPN receives major afferent connections via the fasciculus retroflexus from the habenula (Herrick, 1948;Kemali et al, 1980;Clairambault et al, 1986;Yaiiez and Anadon, 1994), which contains a high density of AR-ir cells. Androgen receptors have not been reported previously in this region in fish or amphibians, but DHT-concentrating cells in the lizard Anolis carolinensis were found to extend ventrally from the mesencephalic tegmental area to the interpeduncular nucleus (Morrell et al, 1979).…”

Section: Pattern Of Ar Localizationmentioning

confidence: 96%

Neuroanatomical distribution of androgen and estrogen receptor-immunoreactive cells in the brain of the male roughskin newt

Davis

Moore

1996

J. Comp. Neurol.

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Immunohistochemistry was used to investigate the neuroanatomical distribution of androgen and estrogen receptors in brains of adult male roughskin newts, Taricha granulosa, collected during the breeding season. Immunoreactive cells were found to be widely distributed in specific brain areas of this urodele amphibian. Androgen receptor-immunoreactive (AR-ir) cells were observed in the olfactory bulbs, habenula, pineal body, preoptic area, hypothalamus, interpeduncular nucleus, area acusticolateralis, cerebellum, and motor nuclei of the medulla oblongata. Estrogen receptor-immunoreactive (ER-ir) cells were found in the lateral septum, amygdala pars lateralis, pallium, preoptic area, hypothalamus, and dorsal mesencephalic tegmentum. This immunocytochemical study of the newt brain reveals AR-ir and ER-ir cells in several regions that have not been previously reported to contain androgen and estrogen receptors in non-mammalian vertebrates. Additionally, the distribution of AR-ir and ER-ir cells in the newt brain, in general, is consistent with previous studies, suggesting that the distribution of sex steroid receptor-containing neurons in some brain regions is relatively conserved among vertebrates.

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Section: Pattern Of Ar Localizationmentioning

confidence: 96%

Neuroanatomical distribution of androgen and estrogen receptor-immunoreactive cells in the brain of the male roughskin newt

Davis

Moore

1996

J. Comp. Neurol.

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“…However, as in our olfactory bulb injections, we observed a dense innervation of the entopeduncular nucleus from the lateral pallium. Because this nucleus projects to the habenula in another elasmobranch [ Chiloscyllium arabicum, Giuliani et al, 2002] as well as in other vertebrates [Filion and Harnois, 1978;Kemali et al, 1980;Yáñez and Anadón, 1996] could be an indirect projection to the habenula in Platyrhinoidis instead of a direct one as in Scyliorhinus .…”

Section: Tertiary Olfactory Projectionsmentioning

confidence: 99%

Organization of Major Telencephalic Pathways in an Elasmobranch, the Thornback Ray Platyrhinoidis triseriata

Hofmann

Northcutt²

2008

Brain Behav Evol

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The forebrain of elasmobranchs is well developed, and in some species the relative brain/body weight is comparable to that in mammals. However, little is known about the organization of major telencephalic pathways. We injected biotinylated dextran amines into the olfactory bulb, lateral pallium, dorsomedial pallium, and the forebrain bundles of the thornback ray, Platyrhinoidis triseriata. Secondary olfactory fibers from the bulb innervate the lateral pallium, the ventral division of the rostral telencephalon and area superficialis basalis. Retrogradely labeled cells were seen exclusively in the lateral periventricular area. The projections of the lateral pallium appeared basically similar to those of the olfactory bulb, but labeling was much denser in the superficial part of area basalis. Some fibers were also seen to innervate the posterior tuberal nucleus. Injections into the dorsomedial pallium revealed a major input from area basalis. Only a few cells were retrogradely labeled in the dorsal thalamus and posterior lateral thalamic nucleus. Major efferents of the dorsomedial pallium appear to reach the contralateral inferior lobe of the hypothalamus and the lateral mesencephalic nucleus. Tracer injections into the forebrain bundles retrogradely labeled many cells in the diencephalon and the mesencephalon and also revealed terminal fields in area superficialis basalis. In addition, a large number of cells were labeled in the dorsomedial pallium. Descending telencephalic fibers innervate heavily the inferior lobes and the lateral mesencephalic nucleus. Our results show that higher order olfactory pathway courses from the lateral pallium through area basalis to the dorsomedial pallium and that ascending non-olfactory input is integrated in area superficialis basalis and the dorsal pallium along with olfactory information, rather than being processed in separate, non-olfactory centers.

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“…B. orientalis is particularly interesting for this purpose because it belongs to a basal group in anuran phylogeny [Pyron and Wiens, 2011] and could provide useful information to elucidate the tetrapod brain morphotype [e.g., Northcutt, 1995] when considering that the more basal caecilians and urodeles underwent substantial secondary brain simplification during their evolutionary history [Roth et al, 1997;Schmidt and Wake, 1997]. Experimental studies of habenular complex connections have previously been conducted in the frog Rana esculenta [Kemali et al, 1980;Kemali and Guglielmotti, 1982;Kemali and Làzàr, 1985;Guglielmotti and Fiorino, 1998], but a precise picture of the projection patterns of different nuclei has yet to be achieved in any amphibian species. In frogs, the habenular complex displays dorsal and ventral nuclei on each side of the brain and the left dorsal nucleus shows conspicuous lateral and medial divisions.…”

mentioning

confidence: 99%

Efferent Axonal Projections of the Habenular Complex in the Fire-Bellied Toad Bombina orientalis

Laberge

Smith²

2017

Brain Behav Evol

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The habenular complex and its associated axonal pathways are often thought of as phylogenetically conserved features of the brain among vertebrates despite the fact that detailed studies of this brain region are limited to a few species. Here, the gross morphology and axonal projection pattern of the habenular complex of an anuran amphibian, the fire-bellied toad Bombina orientalis, was studied to allow comparison with the situation in other vertebrates. Axonal pathways were traced using biocytin applications in dissected brain preparations. The results show that the rostral part of the left dorsal nucleus is enlarged in this species, while the rostral ventral nucleus and caudal parts do not show left-right size differences. Biocytin applications revealed widespread axonal projections of the habenular complex to the posterior tuberculum/dorsal hypothalamic region, ventral tegmentum, interpeduncular nucleus (IPN), and raphe median. Additionally, axons targeting the lateral hypothalamus originated from the ventral habenular nuclei. The results also suggest an asymmetrical pattern of projection to the IPN in the rostral part of the habenular complex, where the left habenula preferentially targeted the dorsal IPN while the right habenula preferentially targeted the ventral IPN. The caudal habenular nuclei showed no asymmetry of projections as both sides targeted the ventral IPN. Comparison of the habenular complex axonal connectivity across vertebrates argues against strong phylogenetic conservation of the axonal projection patterns of different habenular nuclei.

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Neuroanatomical identification of the frog habenular connections using peroxidase (HRP)

Cited by 49 publications

References 22 publications

Neuroanatomical distribution of androgen and estrogen receptor-immunoreactive cells in the brain of the male roughskin newt

Neuroanatomical distribution of androgen and estrogen receptor-immunoreactive cells in the brain of the male roughskin newt

Organization of Major Telencephalic Pathways in an Elasmobranch, the Thornback Ray <i>Platyrhinoidis triseriata</i>

Efferent Axonal Projections of the Habenular Complex in the Fire-Bellied Toad <b><i>Bombina orientalis</i></b>

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