2020
DOI: 10.1503/jpn.180207
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Neuroanatomical predictors of response to subcallosal cingulate deep brain stimulation for treatment-resistant depression

Abstract: Background: Deep brain stimulation targeting the subcallosal cingulate gyrus (SCG DBS) improves the symptoms of treatment-resistant depression in some patients, but not in others. We hypothesized that there are pre-existing structural brain differences between responders and nonresponders to SCG DBS, detectable using structural MRI. Methods: We studied preoperative, T 1 -weighted MRI scans of 27 patients treated with SCG DBS from 2003 to 2011. Responders (n = 15) were patients with a > 50% improvement in Hamil… Show more

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Cited by 27 publications
(15 citation statements)
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References 79 publications
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“…Twenty-six studies were candidates for inclusion at the abstract level. Thirteen studies were excluded because they did not compare active to sham stimulation [31][32][33][34][35][36][37][38][39][40][41][42][43], and one study was excluded as it included only three patients [44]. Therefore, 12 studies [15][16][17][18][19][20][21][22][23][24][25] (186 unique patients) were included in the meta-analysis and meta-regression ( Table 1).…”
Section: Resultsmentioning
confidence: 99%
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“…Twenty-six studies were candidates for inclusion at the abstract level. Thirteen studies were excluded because they did not compare active to sham stimulation [31][32][33][34][35][36][37][38][39][40][41][42][43], and one study was excluded as it included only three patients [44]. Therefore, 12 studies [15][16][17][18][19][20][21][22][23][24][25] (186 unique patients) were included in the meta-analysis and meta-regression ( Table 1).…”
Section: Resultsmentioning
confidence: 99%
“…The large-scale trials, however, did not reveal a significant difference between the control and treatment groups. A number of reasons have been posited to explain these negative results, including choice of stimulation target, electrode placement technique, patient selection, and short-term follow-up of patients [43,[46][47][48][49][50][51][52].…”
Section: Discussionmentioning
confidence: 99%
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“…BA25 is also targeted for deep brain stimulation in patients with treatment-resistant depression, where larger volumes predict better treatment outcomes (Mayberg et al, 2005;Sankar et al, 2019). Subgenual regions of vmPFC have also been identified as components of a central autonomic network monitoring visceral functions (Beissner et al, 2013;Gianaros and Sheu, 2009;Gianaros and Wager, 2015;Myers, 2016;Shoemaker et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…A subregion of the vmPFC, the subgenual cingulate cortex (BA25), is activated by sadness-provoking stimuli, responds to social isolation, and has reduced volume in MDD patients (Beckmann et al, 2009; Liotti et al, 2000; Vijayakumar et al, 2017). BA25 is also targeted for deep brain stimulation in patients with treatment-resistant depression, where larger volumes predict better treatment outcomes (Mayberg et al, 2005; Sankar et al, 2019). Subgenual regions of vmPFC have also been identified as components of a central autonomic network monitoring visceral functions (Beissner et al, 2013; Gianaros and Sheu, 2009; Gianaros and Wager, 2015; Myers, 2016; Shoemaker et al, 2016).…”
Section: Introductionmentioning
confidence: 99%