Neuroanatomy of Dopamine: Reward and Addiction

Taber, Katherine H.; Black, Deborah N.; Porrino, Linda J.; Hurley, Robin A.

doi:10.1176/appi.neuropsych.24.1.1

Cited by 69 publications

(44 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…External factors such as exposure to the light source from the internet device, leading to suppression of melatonin secretion [45], and lack of physical activity that is important for restorative sleep [46] may help in explaining the results. Internal factors reported in other studies such as below-normal functioning of the dopaminergic system are the known risk factors for addiction [47, 48] and activation of sympathetic nervous tone in subjects with IA [49] may contribute to DIS, DMS and DFI. The association of several parasomnias with IA has been previously reported, but parasomnias, including sleep snoring, apnea, bruxism, and nightmares [10, 50] were not evaluated and they could be explainable factors for DMS.…”

Section: Discussionmentioning

confidence: 99%

Poor sleep quality and suicide attempt among adults with internet addiction: A nationwide community sample of Korea

et al. 2017

View full text Add to dashboard Cite

PurposeInternet addiction (IA) is defined as a psychological dependence on the internet, regardless of the type of activities once logged on, and previous studies have focused on adolescents and young adults. The aim of this study was to investigate the association between suicide attempts and sleep among community-dwelling adults with IA.MethodsThe Young’s Internet Addiction Test (IAT), the Korean version of the Composite International Diagnostic Interview (K-CIDI) and a suicide questionnaire were used in this cross-sectional multistage, cluster sampling population-based study. A total of 3212 adults aged 18–64 years were interviewed face-to-face, and they had been randomly selected through a one-person-per-household method.ResultsOf the 3212 adults, 204 were assessed as having IA (6.35%). Adults with IA were younger, and more frequently male, unmarried, and unemployed, and had poorer sleep quality than adults without IA (32.8% vs. 19.8%), whereas there was no significant difference in the absolute duration of sleep between the two groups. Adults with IA showed more frequent difficulty initiating and maintaining sleep, non-restorative sleep, daytime functional impairment, and duration of sleep more than 10 hours on weekdays than adults without IA. IA with poor sleep quality was significantly associated with lifetime suicide attempts (AOR = 3.34, 95% CI 1.38–8.05) after adjusting for demographic covariates. Adults with IA who had more sleep problems showed more severe IA, especially those who experienced a previous suicidal attempt. Among mental disorders, IA with poor sleep quality was significantly associated with anxiety disorder and overall psychiatric disorders.ConclusionsAmong adults with IA, poor sleep quality was found to be associated with more severe IA and lifetime suicide attempt.

show abstract

Section: Discussionmentioning

confidence: 99%

Poor sleep quality and suicide attempt among adults with internet addiction: A nationwide community sample of Korea

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Scores ranged from one to nine (most impaired) with scores greater than five indicating clinically significant impairment, as previously described [3, 8, 20]. The neuropsychological evaluation emphasizes tests that are sensitive to the particular deficits observed in HIV infection and includes seven domains: verbal fluency, speed of information processing, learning, memory, executive functions, attention and working memory, and motor skills.…”

Section: Methodsmentioning

confidence: 99%

“…The presence of HIV-DNA in peripheral monocytes has been linked to HAND, providing a possible link between peripheral immune activation and CNS damage. [20–22]…”

Section: Introductionmentioning

confidence: 99%

Plasma soluble CD163 is associated with postmortem brain pathology in human immunodeficiency virus infection

Bryant

Moore

Burdo

et al. 2017

Aids

View full text Add to dashboard Cite

Objective Higher plasma soluble CD163 (sCD163), shed by monocytes and macrophages, correlates with neurocognitive impairment in human immunodeficiency virus (HIV) infection. We hypothesized that higher antemortem plasma or cerebrospinal fluid sCD163 would be associated with greater postmortem neurodegeneration and/or microgliosis. Design Retrospective, postmortem observational study. Methods We measured sCD163 levels in antemortem plasma (n=54) and cerebrospinal fluid (n=32) samples from 74 HIV+ participants (median 5 months before death) who donated their brains to research at autopsy. Postmortem, we quantified markers of synaptodendritic damage (microtubule-associated protein 2 [MAP2], synaptophysin [SYP]), microgliosis (HLA-DR, ionized calcium binding adaptor molecule 1), astrocytosis (glial fibrillary acidic protein) and impaired protein clearance (beta-amyloid) in frontal cortex, hippocampus, putamen, and internal capsule. Multivariable least-squares regression was used to evaluate the association between plasma or cerebrospinal fluid sCD163 and histological measures, correcting for multiple comparisons. Results Higher plasma sCD163 was associated with lower MAP2 in frontal cortex (B=−0.23, 95% CI −0.41 to −0.06, p=0.04), putamen (B=0.32, 95% CI −0.52 to −0.12, p=0.02), and hippocampus (B=−0.23, 95% CI −0.35 to −0.10, p=0.01), and with lower SYP in hippocampus (B=−0.25, 95% CI −0.42 to −0.03, p=0.02) but not putamen or frontal cortex (p>0.05). Higher plasma sCD163 was associated with higher HLA-DR in putamen (B=0.17, 95% CI 0.08 to 0.26, p = 0.008). Cerebrospinal fluid sCD163 was not associated with any histological measure (p>0.05). Conclusions Higher plasma sCD163 in life is associated with greater synaptodendritic damage and microglial activation in cortical and subcortical brain regions.

show abstract

“…The neurobiology of the reward system including dopamine and opioid systems that mediate the reinforcing effects of addictive drugs, and the importance of the CRF/dynorphin systems that signal increasing drug aversiveness during escalated drug taking are prominent neurobiologic adaptations that contribute to the progression of drug use (Koob, 2010; Koob et al, 2014; Koob & Le Moal, 2001; Taber, Black, Porrino, & Hurley, 2012; Zorrilla, Logrip, & Koob, 2014). …”

Section: Sex/gender Differences In the Neurobiology Of Addictionmentioning

confidence: 99%

Emergence of sex differences in the development of substance use and abuse during adolescence

Kuhn

2015

Pharmacology & Therapeutics

147

109

View full text Add to dashboard Cite

Substance use and abuse begins during adolescence. Male and female adolescent humans initiate use at comparable rates, but males increase use faster. In adulthood, more men than women use and abuse addictive drugs. However, some women progress more rapidly from initiation of use to entry into treatment. In animal models, adolescent males and females consume addictive drugs similarly. However, reproductively mature females acquire self-administration faster, and in some models, escalate use more. Sex/gender differences exist in neurobiologic factors mediating both reinforcement (dopamine, opioids) and aversiveness (CRF, dynorphin), as well as intrinsic factors (personality, psychiatric co-morbidities) and extrinsic factors (history of abuse, environment especially peers and family) which influence the progression from initial use to abuse., Many of these important differences emerge during adolescence, and are moderated by sexual differentiation of the brain. Estradiol effects which enhance both dopaminergic and CRF-mediated processes contribute to the female vulnerability to substance use and abuse. Testosterone enhances impulsivity and sensation seeking in both males and females. Several protective factors in females also influence initiation and progression of substance use including hormonal changes of pregnancy as well as greater capacity for self-regulation and lower peak levels of impulsivity/sensation seeking. Same sex peers represent a risk factor more for males than females during adolescence, while romantic partners increase risk for women during this developmental epoch. In summary, biologic factors, psychiatric co-morbidities as well as personality and environment present sex/gender-specific risks as adolescents begin to initiate substance use.

show abstract

Neuroanatomy of Dopamine: Reward and Addiction

Cited by 69 publications

References 29 publications

Poor sleep quality and suicide attempt among adults with internet addiction: A nationwide community sample of Korea

Poor sleep quality and suicide attempt among adults with internet addiction: A nationwide community sample of Korea

Plasma soluble CD163 is associated with postmortem brain pathology in human immunodeficiency virus infection

Emergence of sex differences in the development of substance use and abuse during adolescence

Contact Info

Product

Resources

About