Neuroapoptosis in newborns with respiratory acidosis at birth

Cañavate-Solano, Consuelo; Quintero-Prado, Rocío; González‐Macías, C.; Soto-Pazos, Estefanía; Sánchez, Ángel Vilar; Mesa-Suárez, Pablo; Ramos-Ramos, Victoria; Cuadros-Muñoz, Juan F.; Mayor-Reyes, María; Pérez-Ramos, Santiago; Alba, Juan Jesús Fernández

doi:10.1016/j.clinbiochem.2019.08.013

Cited by 8 publications

(7 citation statements)

References 13 publications

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“…In the present study, a statistically significant increase was found in the S100B concentration of calves with perinatal asphyxia compared to healthy calves at the time of admission, 24, 48, and 72 h. Higher S100B concentrations in calves with perinatal asphyxia compared to healthy calves have been associated with the development of hypoxic-ischemic encephalopathy [ 50 , 51 ]. In our study, the concomitant elevation of S100B, lactate [ 52 , 53 ], and UCHL1 concentrations in calves with perinatal asphyxia supports the development of hypoxic-ischemic encephalopathy.…”

Section: Discussionsupporting

confidence: 61%

“…In term and preterm infants with hypoxic-ischemic encephalopathy, S100B concentration was found to be elevated within the first 72 h [ 50 ]. In contrast, Nagdyman et al [ 51 ] reported that S100B is rapidly released in hypoxic brain injury and returns to normal ranges within 48 h. Previous studies showed that in the umbilical cord blood of infants born with neonatal asphyxia S100B and lactate concentrations were increased, and these markers could be helpful as an early predictive marker for diagnosis of neonatal hypoxic-ischemic encephalopathy [ 52 , 53 ]. In the present study, a statistically significant increase was found in the S100B concentration of calves with perinatal asphyxia compared to healthy calves at the time of admission, 24, 48, and 72 h. Higher S100B concentrations in calves with perinatal asphyxia compared to healthy calves have been associated with the development of hypoxic-ischemic encephalopathy [ 50 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

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The Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxia

Naseri

Ateş

et al. 2022

Animals

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The purpose of the present study was to determine hypoxic brain damage in calves with perinatal asphyxia using brain-specific damage biomarkers. Ten healthy and 25 calves with perinatal asphyxia were enrolled in the study. Clinical examination, neurological status score, and laboratory analysis were performed at admission, 24, 48, and 72 h. Serum concentrations of ubiquitin carboxy-terminal hydrolysis 1 (UCHL1), calcium-binding protein B (S100B), adrenomodullin (ADM), activitin A (ACTA), neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP) and creatine kinase-brain (CK-B) were measured. Histopathological and immunohistochemical examinations of the brain tissue were performed in 13 nonsurvivor calves. The neurological status score of the calves with asphyxia was significantly (p < 0.05) lower. Mix metabolic-respiratory acidosis and hypoxemia were detected in calves with asphyxia. Serum UCHL1 and S100B were significantly (p < 0.05) increased, and NSE, ACTA, ADM, and CK-B were decreased (p < 0.05) in calves with asphyxia. Histopathological and immunohistochemical examinations confirmed the development of mild to severe hypoxic-ischemic encephalopathy. In conclusion, asphyxia and hypoxemia caused hypoxic-ischemic encephalopathy in perinatal calves. UCHL1 and S100B concentrations were found to be useful markers for the determination of hypoxic-ischemic encephalopathy in calves with perinatal asphyxia. Neurological status scores and some blood gas parameters were helpful in mortality prediction.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

The Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxia

Naseri

Ateş

et al. 2022

Animals

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“…S100B was found to directly correlate with pCO 2 levels, suggesting an association between UA pCO 2 levels and neuronal damage. 15 While this biochemical study offered a possible causal relationship between neuronal damage and pCO 2 levels, it lacked clinically relevant outcomes. A Scandinavian study by Kro et al analyzed UA gases from 25,806 term deliveries and associated Apgar's scores.…”

Section: Discussionmentioning

confidence: 99%

“…[12][13][14] UA hypercarbia may cause neonatal morbidity through many potential mechanisms, including neuronal apoptosis. 15 However, there are only limited, conflicting data on UA pCO 2 and neonatal morbidity. [15][16][17] Most research has focused on UA pH, BE, lactate, and pO 2 .…”

mentioning

confidence: 99%

The Risk of Neonatal Morbidity in Umbilical Artery Hypercarbia and Respiratory Acidosis

et al. 2022

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Objective To test the hypothesis that elevated umbilical artery (UA) partial pressure of carbon dioxide (pCO2) is associated with neonatal morbidity and to compare the risk of neonatal morbidity with different patterns of UA acidosis. Study Design This was a secondary analysis of a prospective cohort of term, singleton, nonanomalous deliveries with universal cord gas collection. The primary outcome was composite neonatal morbidity. Multivariable logistic regression was used to determine the relative risk (RR) for neonatal morbidity in patients with and without UA hypercarbia. A receiver operating characteristic curve determined the predictive value of pCO2 for neonatal morbidity. An additional multivariable logistic regression was used to evaluate the risk of neonatal morbidity in different patterns of UA acidosis. Results UA hypercarbia was associated with an increased risk of neonatal morbidity (RR: 2.56, 95% confidence interval [CI]: [2.07, 3.17]). After adjusting for UA acidemia, this association remained significant (adjusted RR: 1.39, 95% CI: [1.05, 1.83]). UA pCO2 was less predictive of neonatal morbidity than UA pH (area under the curve [AUC]: 0.65, 95% CI: [0.62, 0.68] vs. AUC: 0.72, 95% CI: [0.69, 0.75], p < 0.01). The odds ratios for neonatal morbidity for respiratory, mixed, and metabolic acidosis compared with normal cord gases were 1.48 (95% CI: [0.88, 2.49]), 6.41 (95% CI: [3.68, 11.17]), and 7.49 (95% CI: [5.76, 9.72]), respectively, p-trend < 0.01. Conclusion UA hypercarbia is an independent predictor of neonatal morbidity, even in the setting of concomitant UA acidemia. UA mixed and metabolic acidosis carry significantly greater risk of neonatal morbidity compared with respiratory acidosis. Key Points

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“…Utilising biosensors that target biomarkers could lead to the generation of low cost devices that are able to be easily used in the diagnostics or progression monitoring of different disease states [56] that would be useful in a point of care setting [57]. The pH of biological fluids is a biomarker, for example blood pH is a biomarker for acidosis [58,59] and salivary pH is a biomarker indicating the seriousness of periodontal disease [60].…”

Section: Biomarker Biosensorsmentioning

confidence: 99%

The Development of Electrochemical Sensors and their Application in Real Biological Environments

Whelan

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The author would also like to thank Professor Owen Guy who whilst not a member of the supervisory team has also contributed to the support and guidance of the author over the course of the project as well as Zimmer & Peaock and KESS2 for project funding.The author would like to thank friends and family including Shirin Naserikarimvand, Peter, Kim and Liam Whelan as well as colleagues at the Centre for Nanohealth.

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Neuroapoptosis in newborns with respiratory acidosis at birth

Cited by 8 publications

References 13 publications

The Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxia

The Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxia

The Risk of Neonatal Morbidity in Umbilical Artery Hypercarbia and Respiratory Acidosis

The Development of Electrochemical Sensors and their Application in Real Biological Environments

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