Neurobehavior in fetal life

Kurjak, Asım; Stanojević, Milan; Predojević, Maja; Lausin, Iva; Salihagič-Kadić, Aida

doi:10.1016/j.siny.2012.06.005

Cited by 93 publications

(17 citation statements)

References 22 publications

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“…These include responsiveness to vibroacoustic stimuli (Divon et al, 1985), qualitative fetal movement patterns (Birnholz et al, 1978), and scoring of enumerated behaviors observed via ultrasound (Kurjak, Stanojevic, Predojevic, Lausin, & Salihagic-Kadic, 2012; Salisbury, Fallone, & Lester, 2005). However, we concur with Einspieler et al (2012) that the field is far from establishing a fetal exam based on patterning of motor behavior or any other performance metric.…”

Section: Chapter 13 Fetal Neurobehavioral Research Reimaginedmentioning

confidence: 99%

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DiPietro¹,

Costigan²,

Voegtline³

2015

Monographs Society Res Child

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Among the earliest volumes of this Monograph series was a report by Lester Sontag and colleagues, of the esteemed Fels Institute, on the heart rate of the human fetus as an expression of the developing nervous system. Here, some 75 years later, we commemorate this work and provide historical and contemporary context on knowledge regarding fetal development, as well as results from our own research. These are based on synchronized monitoring of maternal and fetal parameters assessed between 24 and 36 weeks gestation on 740 maternal-fetal pairs compiled from eight separate longitudinal studies, which commenced in the early 1990s. Data include maternal heart rate, respiratory sinus arrhythmia, and electrodermal activity and fetal heart rate, motor activity, and their integration. Hierarchical linear modeling of developmental trajectories reveals that the fetus develops in predictable ways consistent with advancing parasympathetic regulation. Findings also include: within-fetus stability (i.e., preservation of rank ordering over time) for heart rate, motor, and coupling measures; a transitional period of decelerating development near 30 weeks gestation; sex differences in fetal heart rate measures but not in most fetal motor activity measures; modest correspondence in fetal neurodevelopment among siblings as compared to unrelated fetuses; and deviations from normative fetal development in fetuses affected by intrauterine growth restriction and other conditions. Maternal parameters also change during this period of gestation and there is evidence that fetal sex and individual variation in fetal neurobehavior influence maternal physiological processes and the local intrauterine context. Results are discussed within the framework of neuromaturation, the emergence of individual differences, and the bidirectional nature of the maternal-fetal relationship. We pose a number of open questions for future research. Although the human fetus remains just out of reach, new technologies portend an era of accelerated discovery of the earliest period of development.

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Section: Chapter 13 Fetal Neurobehavioral Research Reimaginedmentioning

confidence: 99%

Untitled

DiPietro¹,

Costigan²,

Voegtline³

2015

Monographs Society Res Child

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“…Second, subjective determination to evaluate fetal facial expressions obtained by 4D HDlive ultrasound might lead to inter-observer variability [13,25]. Although relatively good intra-and inter-class correlation coefficients were obtained in the present study, further investigations are required [14,27]. Third, fetal consciousness state at the ultrasound examination were not determined.…”

Section: Page 7 Ofmentioning

confidence: 60%

Facial Expressions of Fetal Growth Restriction and Appropriate-for-Gestational Age Fetuses Assessed by Four-Dimensional High-Definition Live Ultrasound

Chida¹,

Kikuchi²,

Kanasugi³

et al. 2017

Gynecol Obstet

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Objective: To determine whether Fetal Growth Restriction (FGR) fetuses have less facial expressions than Appropriate-for-Gestational Age (AGA) counterparts with the assessment by four-dimensional high-definition live (4D HDlive) ultrasound.Methods: 4D HDlive ultrasound examinations of fetal facial expressions were performed on singleton pregnant women between 26 and 39 weeks of gestation. The duration of the 4D HDlive recordings was 15 minutes in all cases. The frequency of seven types of previously-reported facial expressions, or blinking, mouthing, yawning, tongue expulsion, sucking, smiling and scowling, were assessed. Two observers counted the frequencies, and inter-and intra-observer reproducibility was examined. Wilcoxon rank-sum test was used for comparison of FGR and AGA group. Kruskal-Wallis test was used for intra-group significance of frequencies of seven types of fetal facial expressions. P<0.05 was considered significant. Results:In this study, good intra-and inter-class correlation coefficients and intra-and inter-observer agreements were obtained. Thus, measurement values by only one examiner were used for further analysis. The facial expressions of 16 fetuses (FGR: n=8, AGA: n=8) were assessed. We noted a tendency for FGR fetuses to have less facial expressions than AGA counterparts. Although statistically significant inter-group difference was not detected in frequency of any facial expressions, this propensity is conspicuous in smiling (p=0.065) and mouthing (p=0.279). In AGA fetuses, the commonest facial expression was mouthing and was significantly more frequent than blinking (p=0.007), tongue expulsion (p=0.007) and sucking (p=0.002). We also noted a tendency that the frequency of facial expressions declines with fetal maturation. Although no statistically significant difference was shown, this propensity is prominent in mouthing of FGR (p=0.071). Conclusion:4D HDlive ultrasound provides promising modalities in novel evaluative imaging of fetal various facial expressions, and may help to elucidate functional development of Central Nervous System (CNS) and facial expressions both in normal and compromised fetuses.

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“…The data and their interpretation in the present study should be viewed with some degree of caution because of the small number of subjects. Moreover, the diagnostic indices of the KANET test, as well as the intra-and interobserver reproducibility, have yet to be validated [14]. Another limitation of this test is that it requires a highly experienced examiner who is familiar with fetal neurobehavior and can perform precise KANET evaluation.…”

Section: Discussionmentioning

confidence: 99%

Does ethnicity have an effect on fetal behavior? A comparison of Asian and Caucasian populations

Hanaoka

Hata

Kanenishi

et al. 2016

Journal of Perinatal Medicine

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Our results suggest that ethnicity should be considered when evaluating fetal behavior, especially during assessment of fetal facial expressions. Although there was a difference in the total KANET score between Japanese and Croatian populations, all the scores in both groups were within normal range. Our results indicate that ethnical differences in fetal behaviour do not affect the total KANET score, but close follow-up should be continued in some borderline cases.

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Neurobehavior in fetal life

Cited by 93 publications

References 22 publications

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Untitled

Facial Expressions of Fetal Growth Restriction and Appropriate-for-Gestational Age Fetuses Assessed by Four-Dimensional High-Definition Live Ultrasound

Does ethnicity have an effect on fetal behavior? A comparison of Asian and Caucasian populations

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