2022
DOI: 10.21203/rs.3.rs-2152573/v1
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Neurobehavioral and neurochemical basis of compulsive behavior: A 7T magnetic resonance spectroscopy study in humans

Abstract: There has been relatively little analysis of possible neurochemical correlates of compulsive behavior to illuminate its underlying neural mechanisms. We utilised 7-Tesla proton magnetic resonance spectroscopy (1H-MRS) to assess the balance of excitatory and inhibitory neurotransmission by measuring glutamate and GABA levels in anterior cingulate cortex and supplementary motor area (SMA) of healthy volunteers and patients with Obsessive-Compulsive Disorder (OCD). Within the SMA, trait and clinical measures of c… Show more

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