Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Review of Evidence and Guidelines for Assessment

Doyle, Lauren R; Mattson, Sarah N.

doi:10.1007/s40474-015-0054-6

Cited by 61 publications

(37 citation statements)

References 92 publications

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“…It has been widely applied in epidemiologic studies 14,93 and in clinical settings and has been found to accurately describe the end of the continuum of FASD without dysmorphology. 111,112 In contrast, ND-PAE is an experimental mental health diagnostic code that is intended to be used in clinical settings by clinicians from a variety 99,114 An ARND diagnosis can be made based on global cognitive deficits alone without the behavioral issues that fall into the psychiatric realm. ARND also can be diagnosed if there is evidence of behavioral deficits in at least 2 behavioral domains in the absence of cognitive deficits.…”

Section: Differentiation Between Arnd and Neurobehavioral Disorder Wimentioning

confidence: 99%

Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders

et al. 2016

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The adverse effects of prenatal alcohol exposure constitute a continuum of disabilities (fetal alcohol spectrum disorders [FASD]). In 1996, the Institute of Medicine established diagnostic categories delineating the spectrum but not specifying clinical criteria by which diagnoses could be assigned. In 2005, the authors published practical guidelines operationalizing the Institute of Medicine categories, allowing for standardization of FASD diagnoses in clinical settings. The purpose of the current report is to present updated diagnostic guidelines based on a thorough review of the literature and the authors' combined expertise based on the evaluation of >10 000 children for potential FASD in clinical settings and in epidemiologic studies in conjunction with National Institute on Alcohol Abuse and Alcoholismfunded studies, the Collaborative Initiative on Fetal Alcohol Spectrum Disorders, and the Collaboration on FASD Prevalence. The guidelines were formulated through conference calls and meetings held at National Institute on Alcohol Abuse and Alcoholism offices in Rockville, MD. Specific areas addressed include the following: precise definition of documented prenatal alcohol exposure; neurobehavioral criteria for diagnosis of fetal alcohol syndrome, partial fetal alcohol syndrome, and alcohol-related neurodevelopmental disorder; revised diagnostic criteria for alcoholrelated birth defects; an updated comprehensive research dysmorphology scoring system; and a new lip/philtrum guide for the white population, incorporating a 45-degree view. The guidelines reflect consensus among a large and experienced cadre of FASD investigators in the fields of dysmorphology, epidemiology, neurology, psychology, developmental/ behavioral pediatrics, and educational diagnostics. Their improved clarity and specificity will guide clinicians in accurate diagnosis of infants and children prenatally exposed to alcohol. abstract

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Section: Differentiation Between Arnd and Neurobehavioral Disorder Wimentioning

confidence: 99%

Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders

et al. 2016

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“…3,12–14 In fact, only ~25% of children affected by in utero exposure to alcohol exhibit physical features. 15 In 2011, under the auspices of the Interagency Coordinating Committee on Fetal Alcohol Spectrum Disorders, the National Institute on Alcohol Abuse and Alcoholism and the CDC convened a panel of experts to evaluate the research on FASDs not associated with the typical physical features.…”

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confidence: 99%

Neurobehavioral Disorder Associated With Prenatal Alcohol Exposure

et al. 2016

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Children and adolescents affected by prenatal exposure to alcohol who have brain damage that is manifested in functional impairments of neurocognition, self-regulation, and adaptive functioning may most appropriately be diagnosed with neurobehavioral disorder associated with prenatal exposure. This Special Article outlines clinical implications and guidelines for pediatric medical home clinicians to identify, diagnose, and refer children regarding neurobehavioral disorder associated with prenatal exposure. Emphasis is given to reported or observable behaviors that can be identified as part of care in pediatric medical homes, differential diagnosis, and potential comorbidities. In addition, brief guidance is provided on the management of affected children in the pediatric medical home. Finally, suggestions are given for obtaining prenatal history of in utero exposure to alcohol for the pediatric patient.

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“…25,26 However, research has yet to delineate a specific neurobehavioral profile or core symptoms of FASD. 1 Given the variable effects of dose, timing and pattern of alcohol use during pregnancy, 27 in conjunction with varying stages of CNS development, the identification of a central neurobehavioral profile common to all patients with FASD is formidable.…”

Section: Discussionmentioning

confidence: 99%