Neurobehavioral effect of essential oil of Cymbopogon citratus in mice

Blanco, Miriam Marcela; Costa, Celso A. R. A.; Freire, A.O.; Santos, Juliana; Costa, Maria Kátia Matiotti Da

doi:10.1016/j.phymed.2007.04.007

Cited by 154 publications

(102 citation statements)

References 17 publications

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“…The major constituents were geranial (43.08%), neral (32.19%) and mircene (17.58%) ( Table 1). The percentages obtained in the present work were similar to those demonstrated in other studies for the same species (Blanco et al, 2009;Guimarães et al, 2008). Furthermore, it did not find in the literature any study demonstrating the activity of these constituents on the cardiovascular system.…”

Section: Resultssupporting

confidence: 92%

“…Stapf, Poaceae, is an aromatic medicinal plant popularly known as "capim-santo" and used in the folk medicine as anxyolitic and anti-hypertensive. Several pharmacological effects were studies such as: analgesic, sedative/hypnotic, anxiolytic, anticonvulsant (Viana et al, 2000;Blanco et al, 2009). Some studies have shown that the endovenous administration of aqueous and hydroalcoholic extracts of leaves of C. citratus present anti-hypertensive effect in rats (Carbajal et al, 1989;Singi et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Chemical composition and cardiovascular effects induced by the essential oil of Cymbopogon citratus DC. Stapf, Poaceae, in rats

Moreira¹,

Bastos²,

Blank³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Composição química e efeitos cardiovasculares do óleo essencial de Cymbopogon citratus DC. Stapf, Poaceae, em ratos". C. citratus é utilizada na medicina popular para tratar hipertensão. Este trabalho investigou a composição química e os efeitos cardiovasculares do óleo essencial do C. citratus (OECC). Foram identificados oito constituintes no OECC, sendo geranial o majoritário (43,08%). Em ratos, o OECC (1, 5, 10 e 20 mg/kg, i.v.) induziu hipotensão e bradicardia que foram atenuadas pela atropina e tiopental sódico, mas não por L-NAME ou indometacina. Em anéis de artéria mesentérica de ratos pré-contraídos com fenilefrina, o OECC (1 a 3000 µg/mL) induziu relaxamento que não foi afetado após remoção do endotélio, após TEA ou em anéis pré-contraídos com KCl (80 mM). Além disso, o OECC (1000 µg/mL) não induziu efeito adicional sobre o relaxamento máximo da nifedipina (10 µM). Em conclusão, o OECC induz hipotensão possivelmente devido à redução da resistência vascular que pode ser causada por inibição do influxo de Ca 2+ , e bradicardia provavelmente devido à ativação de receptores muscarínicos cardíacos.Unitermos: Cymbopogon citratus, óleo essencial, efeitos cardiovasculares, ratos. ABSTRACT:Cymbopogon citratus DC. Stapf, Poaceae, is used in the folk medicine for hypertension treatment. This work investigated the chemical composition and cardiovascular effects in rats of C. citratus essential oil (EOCC). A phytochemical screening demonstrated the presence of eight constituents, being geranial the major compound (43.08%). In rats, EOCC (1, 5, 10, and 20 mg/kg, i.v.) induced transient hypotension and bradycardia that were attenuated by atropine and sodium thiopental, but not by L-NAME or indomethacin. In rings of rat superior mesenteric artery pre-contracted with phenylephrine, EOCC (1 to 3000 µg/mL) induced relaxation that was not affected after removal of the endothelium, after TEA or in rings pre-contracted with KCl (80 mM). Furthermore, EOCC (1000 µg/mL) was not able to induce additional effect on maximal relaxation of nifedipine (10 µM). In conclusions, EOCC induces hypotension, possibly by reduction in vascular resistance caused by inhibition of the Ca 2+ influx, and bradycardia probably due to an activation of cardiac muscarinic receptors.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Chemical composition and cardiovascular effects induced by the essential oil of Cymbopogon citratus DC. Stapf, Poaceae, in rats

Moreira¹,

Bastos²,

Blank³

et al. 2010

Rev. bras. farmacogn.

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“…It can also act as an antidepressant and as a mood enhancer. Other researches also reported hypoglycemic, hypolipidemic, anxiolytic, sedative (Blanco et al, 2009) and antiox-idant properties (Pereira et al, 2009;Figueirinha et al, 2008;Cheel et al, 2005;Cheah et al 2001).…”

Section: Introductionmentioning

confidence: 93%

Angolan Cymbopogon citratus used for therapeutic benefits: Nutritional composition and influence of solvents in phytochemicals content and antioxidant activity of leaf extracts

Soares

Alves

Pires

et al. 2013

Food and Chemical Toxicology

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A B S T R A C TFolk medicine is a relevant and effective part of indigenous healthcare systems which are, in practice, totally dependent on traditional healers. An outstanding coincidence between indigenous medicinal plant uses and scientifically proved pharmacological properties of several phytochemicals has been observed along the years.This work focused on the leaves of a medicinal plant traditionally used for therapeutic benefits (Ango-lan Cymbopogon citratus), in order to evaluate their nutritional value. The bioactive phytochemical com-position and antioxidant activity of leaf extracts prepared with different solvents (water, methanol and ethanol) were also evaluated.The plant leaves contained rv60% of carbohydrates, protein (rv20%), fat (rv5%), ash (rv4%) and moisture (rv9%). The phytochemicals screening revealed the presence of tannins, flavonoids, and terpenoids in all extracts. Methanolic extracts also contained alkaloids and steroids. Several methods were used to eval-uate total antioxidant capacity of the different extracts (DPPH . , NO . , and H2O2 scavenging assays, reducing power, and FRAP). Ethanolic extracts presented a significantly higher antioxidant activity (p < 0.05) except for FRAP, in which the best results were achieved by the aqueous extracts. Methanolic extracts showed the lowest radical scavenging activities for both DPPH . and NO . radicals.

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“…1,2 Lemongrass (Cymbopogon citratus Stapf) leaves have been widely consumed as infusions or decoctions in Brazilian folk medicine to treat ailments because of their antispasmodic, analgesic, anti-inflammatory, antipyretic, diuretic, and sedative properties. 3,4 In addition, lemongrass essential oil (LGEO) has an immense commercial value as a food preservative, flavoring agent, and ingredient in fragrances and cosmetics. 2 Also, various in vitro and in vivo pharmacological activities of LGEO have been described, including anxiolytic and anticonvulsant activities, 4,5 antibacterial, antifungal, and antiprotozoal properties, [6][7][8][9][10] potential immunostimulating action, and antiviral activity against herpes simplex virus type 1.…”

Section: Introduction Ementioning

confidence: 99%

“…3,4 In addition, lemongrass essential oil (LGEO) has an immense commercial value as a food preservative, flavoring agent, and ingredient in fragrances and cosmetics. 2 Also, various in vitro and in vivo pharmacological activities of LGEO have been described, including anxiolytic and anticonvulsant activities, 4,5 antibacterial, antifungal, and antiprotozoal properties, [6][7][8][9][10] potential immunostimulating action, and antiviral activity against herpes simplex virus type 1. 11,12 Previous in vitro and in vivo studies have shown antimutagenic and antioxidant activities of lemongrass extracts or their main compounds (i.e., citral, b-myrcene, and geraniol).…”

Section: Introduction Ementioning

confidence: 99%

Modifying Effects of Lemongrass Essential Oil on Specific Tissue Response to the Carcinogen N-Methyl-N-Nitrosurea in Female BALB/c Mice

Bidinotto

Costa²,

Costa³

et al. 2012

Journal of Medicinal Food

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Lemongrass (Cymbopogon citratus Stapf) essential oil has been used worldwide because of its ethnobotanical and medicinal usefulness. Regarding its medicinal usefulness, the present study evaluated the beneficial effects of lemongrass essential oil (LGEO) oral treatment on cell proliferation and apoptosis events and on early development of hyperplastic lesions in the mammary gland, colon, and urinary bladder induced by N-methyl-N-nitrosourea (MNU) in female BALB/c mice. The animals were allocated into three groups: G1, treated with LGEO vehicle for 5 weeks (five times per week); G2, treated with LGEO vehicle as for G1 and MNU (two injections each of 30 mg/kg of body weight at weeks 3 and 5); and G3, treated with LGEO (five times each with 500 mg/kg of body weight per week) and MNU as for G2. Twenty-four hours after the last MNU application, all animals were euthanized, and mammary glands, colon, and urinary bladder were collected for histological and immunohistochemical analysis.LGEO oral treatment significantly changed the indexes of apoptosis and/or cellular proliferation for the tissues analyzed. In particular, the treatment reduced the incidence of hyperplastic lesions and increased apoptosis in mammary epithelial cells. This increment in the apoptosis response may be related to a favorable balance in Bcl-2/Bax immunoreactivity in mammary epithelial cells. These findings indicate that LGEO presented a protective role against early MNU-induced mammary gland alterations in BALB/c mice.

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Neurobehavioral effect of essential oil of Cymbopogon citratus in mice

Cited by 154 publications

References 17 publications

Chemical composition and cardiovascular effects induced by the essential oil of Cymbopogon citratus DC. Stapf, Poaceae, in rats

Chemical composition and cardiovascular effects induced by the essential oil of Cymbopogon citratus DC. Stapf, Poaceae, in rats

Angolan Cymbopogon citratus used for therapeutic benefits: Nutritional composition and influence of solvents in phytochemicals content and antioxidant activity of leaf extracts

Modifying Effects of Lemongrass Essential Oil on Specific Tissue Response to the Carcinogen N-Methyl-N-Nitrosurea in Female BALB/c Mice

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