Neurobehavioral effects of alcohol in overcrowded male adolescent rats

Sabry, Fatma M.; Ibrahim, Michael K.; Hamed, Mohammad; Ahmed, Helmy

doi:10.1016/j.neulet.2020.135084

Cited by 6 publications

(6 citation statements)

References 57 publications

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“…Regarding the animal age, our analyses bring novelty once performed in 41 post-natal days the life stage when the CNS has established the neural maturation and synaptic refinement [62] . Thus, this makes our data representative, as it shows that maternal exposure during pregnancy and lactation can generate biochemical and functional damages to the nervous system of the offspring even after the established maturation of this system and persist significant damages after a breakdown period between administration and animal evaluation, providing evidence to the literature for new research in the literature of effects MeHg-induced beyond the teratogenic damage.…”

Section: Discussionmentioning

confidence: 99%

Methylmercury exposure during prenatal and postnatal neurodevelopment promotes oxidative stress associated with motor and cognitive damages in rats: an environmental-experimental toxicology study

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Methylmercury exposure during prenatal and postnatal neurodevelopment promotes oxidative stress associated with motor and cognitive damages in rats: an environmental-experimental toxicology study

et al. 2022

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“…In the present study, we found that AAE does not impair sociability when assessed by the 3‐chamber test, neither short‐ or long‐term after AAE. Interestingly, Sabry et al showed that AAE did not affect sociability in adolescent male rats but suppressed sociability when coupled to overcrowding conditions 51 . This suggests that alcohol exposure per se may not be sufficient to affect sociability but rather enhances the development of social issues when associated with social stress 51 .…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, Sabry et al showed that AAE did not affect sociability in adolescent male rats but suppressed sociability when coupled to overcrowding conditions. 51 This suggests that alcohol exposure per se may not be sufficient to affect sociability but rather enhances the development of social issues when associated with social stress. 51 We also showed that AAE does not alter the social novelty preference in adolescence.…”

Section: Discussionmentioning

confidence: 99%

Voluntary alcohol binge‐drinking in adolescent C57Bl6 mice induces delayed appearance of behavioural defects in both males and females

et al. 2021

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Adolescence is a developmental period characterized by significant changes in brain architecture and behaviour. The immaturity of the adolescent brain is associated with heightened vulnerability to exogenous agents, including alcohol. Alcohol is the most consumed drug among teenagers, and binge-drinking during adolescence is a major public health concern. Studies have suggested that adolescent alcohol exposure may interfere with the maturation of frontal brain regions and lead to long-lasting behavioural consequences. In this study, by using a slightly modified version of the Drinking in the Dark paradigm, adolescent C57Bl6 mice reach high blood alcohol concentration after voluntary binge-drinking. In order to assess short-and long-term consequences of adolescent alcohol exposure (AAE), a battery of behavioural tests was performed during late adolescence and during adulthood. We showed that AAE had no short-term effect on young mice behaviour but rather increased anxiety-and depressive-like behaviours, as well as alcohol consumption during adulthood. Moreover, alcohol binge-drinking during adolescence dramatically decreased recognition memory performances and behavioural flexibility in both adult males and females.

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“…Interestingly, Sabry et al showed that AAE did not affect sociability in adolescent male rats, but suppressed sociability when coupled to overcrowding conditions 50 . This suggests that alcohol exposure per se may not be sufficient to affect sociability, but rather enhances the development of social issues when associated with social stress 50 . We also showed that AAE does not alter the social novelty preference in adolescence.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, we found that AAE does not impairs sociability when assessed by the 3-chamber test, neither short-or longterm after AAE, as all groups significantly preferred to investigate a novel mouse over an empty wired cup. Interestingly, Sabry et al showed that AAE did not affect sociability in late adolescent male rats, but suppressed sociability when coupled to overcrowding conditions (51). This interesting result suggests that alcohol exposure per se may not be sufficient to affect sociability, but may enhance the development of social issues when associated with social stress (51).…”

Section: Aae Does Not Lead To Sociability Defectsmentioning

confidence: 99%

Adolescent alcohol binge-drinking induces delayed appearance of behavioral defects in mice

Hees

Didone

Charlet-Briar

et al. 2020

Preprint

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Adolescence is a developmental period characterized by significant changes in brain architecture and behaviors. The immaturity of the adolescent brain is associated with heightened vulnerability to exogenous agents, including alcohol. Alcohol is the most consumed drug among teenagers, and binge-drinking during adolescence is a major public health concern. Studies have suggested that, by interfering with brain maturation, adolescent alcohol exposure (AAE) may have profound and long-lasting behavioral consequences. In this study, we used an AAE model, in which adolescent male and female mice reach high blood alcohol concentration after voluntarily binge-drinking. In order to assess the short- and long-term consequences of AAE, a battery of behavioral tests was performed during late adolescence and adulthood. We showed that AAE had no short-term effect on young mice behaviors but rather increased anxiety- and depressive-like behaviors, as well as alcohol consumption during adulthood. Moreover, alcohol binge-drinking during adolescence dramatically decreased recognition memory performances and behavioral flexibility in both adult males and females. Our data suggest that AAE insidiously impairs adult behaviors, without any warning sign in late adolescence.

show abstract

Neurobehavioral effects of alcohol in overcrowded male adolescent rats

Cited by 6 publications

References 57 publications

Methylmercury exposure during prenatal and postnatal neurodevelopment promotes oxidative stress associated with motor and cognitive damages in rats: an environmental-experimental toxicology study

Methylmercury exposure during prenatal and postnatal neurodevelopment promotes oxidative stress associated with motor and cognitive damages in rats: an environmental-experimental toxicology study

Voluntary alcohol binge‐drinking in adolescent C57Bl6 mice induces delayed appearance of behavioural defects in both males and females

Adolescent alcohol binge-drinking induces delayed appearance of behavioral defects in mice

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