Neurobehavioral effects of chronic low-dose risperidone administration in juvenile male rats

Boman, Lindsey; Butte, Maxine De

doi:10.1016/j.bbr.2019.02.009

Cited by 6 publications

(4 citation statements)

References 46 publications

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“…However, Boman and De Butte (2019) found that risperidone leads to spatial learning reduction. In addition to dopamine, there are different neurotransmitters in hippocampus.…”

Section: Discussionmentioning

confidence: 99%

“…Risperidone is a remarkable antagonist of 5HT2A serotonin and dopamine receptor D2, and its lower doses can alleviate the negative effects of schizophrenia (Goodman & Gilman's, 2014). However, Boman and De Butte (2019) found that risperidone leads to spatial learning reduction. In addition to dopamine, there are different neurotransmitters in hippocampus.…”

Section: Discussionmentioning

confidence: 99%

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Effect of risperidone on morphine‐induced conditioned place preference and dopamine receptor D2 gene expression in male rat hippocampus

et al. 2023

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Background: Previous studies suggest the possible effect of risperidone on brain reward system and D1 and D2 dopamine receptors' involvement in morphine-induced conditioned place preference (CPP). Aims:The present study was designed to investigate the effect of risperidone as an atypical antipsychotic drug on morphine-induced CPP and D2-like dopamine receptor gene expression in rat. Materials and Methods:An unbiased CPP paradigm was used to study the effect of risperidone. Intraperitoneal (i.p.) injection of risperidone (1, 2, and 4 mg/kg) was performed 30 min before the morphine (10 mg/kg, i.p.) injection and just after the rat was placed in the CPP box. The open field test was used to assay the locomotor activity of animal. The gene expression of D2 dopamine receptor in hippocampus was measured by real-time PCR technique. The hippocampi of rats were also used for histology evaluation.Results: Morphine-produced (10 mg/kg) CPP and morphine-induced CPP were reversed only by the administration of a low dose of risperidone (1 mg/kg). Low dose of risperidone (1 mg/kg) showed no effect on locomotor activity but a higher dose of risperidone (2 and 4 mg/kg) decreased locomotor activity. Real-time PCR data analysis revealed that the gene expression of D2 dopamine receptor had significant difference between morphine and a 1 mg/kg dose of risperidone. Moreover, in histological evaluation, apoptosis was observed in the morphine group, whereas there was no evidence of apoptosis in the risperidone-treated groups. Conclusion:Our results suggest that risperidone (1 mg/kg) reverses the morphineinduced CPP and may reduce the rewarding properties of morphine. It is also demonstrated that risperidone decreases the expression of D2 receptor in rat hippocampus. Therefore, risperidone can be considered potential adjunct therapy in morphine dependence.

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“…However, Boman and De Butte (2019) found that risperidone leads to spatial learning reduction. In addition to dopamine, there are different neurotransmitters in hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of risperidone on morphine‐induced conditioned place preference and dopamine receptor D2 gene expression in male rat hippocampus

et al. 2023

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“…Since the brain is especially susceptible to hypoxia ( Sharp and Bernaudin, 2004 ), and CNTNAP2 is specifically expressed in the nervous system ( Poliak et al, 1999 ), CNTNAP2 could be a key molecule of the brain in response to hypoxia conditions. Hypoxia is recognized as a risk factor at perinatal period ( Aplin, 2000 ; Boman and De Butte, 2019 ), inducing ASD-like behaviors in offspring ( Wang et al, 2021b ). Besides injury in the cortex, chronic hypoxic brain damage also shows in synaptic loss in preterm infants ( Wang et al, 2018 ) and synaptic plasticity deficits ( Kazim et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, CNTNAP2 and hypoxia are both implicated in ASD during early development. Hypoxia is a critical environmental risk factor for ASD pathogenesis at the perinatal stage ( Aplin, 2000 ; Boman and De Butte, 2019 ), while born CNTNAP2 malfunction contributes to ASD pathogenesis in human and animal studies ( Bakkaloglu et al, 2008 ; Penagarikano et al, 2011 ; Penagarikano and Geschwind, 2012 ; Scott et al, 2020 ). Our results demonstrate that CNTNAP2 is upregulated by hypoxia in adolescence.…”

Section: Discussionmentioning

confidence: 99%

Intermittent hypoxia-induced enhancement of sociability and working memory associates with CNTNAP2 upregulation

Zhang

Yang

et al. 2023

Front. Mol. Neurosci.

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IntroductionHypoxia is an environmental risk factor for many disorders throughout life. Perinatal hypoxia contributes to autism spectrum disorder (ASD), while hypoxic conditions in the elderly facilitate memory deficits. However, the effects of hypoxia on adolescence remains elusive. CNTNAP2 is a critical molecule in ASD pathogenesis with undefined mechanisms. We investigate hypoxia’s impact on adolescence and the underlying mechanism related to CNTNAP2.MethodsThree-chamber social approach test, Y maze, Morris Water Maze and Open Field Test were applied to evaluate behavioral alterations. Immunoblotting, 5′- RACE and dual-luciferase reporter assay were performed to examine CNTNAP2 protein expression, transcription start site (TSS) of human CNTNAP2 gene and CNTNAP2 promoter activity, respectively.ResultsIntermittent hypoxia treatment improved social behaviors and working memory in adolescent mice. CNTNAP2 was increased in the brains of hypoxia-treated mice. The sequencing results identified the TSS at 518 bp upstream of the translation start site ATG. Hypoxia upregulated CNTNAP2 by interacting with functional hypoxia response elements in CNTNAP2 promoter.ConclusionIntermittent hypoxia enhanced sociability and working memory associated with CNTNAP2 upregulation. Our study provides novel insights into intermittent hypoxia’s impact on development and the interaction between genetic and environmental risk factors in ASD pathogenesis.

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Morphological characterization of optimized risperidone-loaded in-situ gel forming implants with pharmacokinetic and behavioral assessments in rats

Ibrahim

Eissa

El-Megrab

et al. 2021

Journal of Drug Delivery Science and Technology

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Neurobehavioral effects of chronic low-dose risperidone administration in juvenile male rats

Cited by 6 publications

References 46 publications

Effect of risperidone on morphine‐induced conditioned place preference and dopamine receptor D2 gene expression in male rat hippocampus

Effect of risperidone on morphine‐induced conditioned place preference and dopamine receptor D2 gene expression in male rat hippocampus

Intermittent hypoxia-induced enhancement of sociability and working memory associates with CNTNAP2 upregulation

Morphological characterization of optimized risperidone-loaded in-situ gel forming implants with pharmacokinetic and behavioral assessments in rats

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