Neurobehavioral effects of dietary soy phytoestrogens

Lephart, Edwin D.; West, Timothy W.; Weber, K. Scott; Rhees, Reuben W.; Setchell, Kenneth D.R.; Adlercreutz, Herman; Lund, Trent D.

doi:10.1016/s0892-0362(01)00197-0

Cited by 190 publications

(132 citation statements)

References 127 publications

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“…24 In male and female rats, phytoestrogens appear anxiolytic, and have sexually dimorphic effects on visual-spatial memory. 25 To date, only estrogen receptor beta (ERb) has been detected in 5-HT neurons of macaques, 26,27 so our study indicates that SPEs are agonists at ERb in the context of 5-HT neurons.…”

Section: Discussionmentioning

confidence: 65%

Soy and social stress affect serotonin neurotransmission in primates

Shively

Mirkes

et al. 2003

Pharmacogenomics J

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Stress and sex steroidal milieu can each influence mood in women. The purpose of this study was to compare the effect of long-term conjugated equine estrogen (CEE), soy phytoestrogen (SPE), and social subordination stress on dorsal raphe serotonin neurotransmission of ovariectomized cynomolgus monkeys. Tryptophan hydroxylase (TPH) and serotonin reuptake transporter (SERT) protein content were determined, and the in vitro degradation of macaque SERT protein was examined in the presence and absence of protease inhibitors, serotonin (5-HT), and citalopram. Like CEE, SPE increased TPH protein levels. Social subordinates had markedly lower TPH protein levels than dominants regardless of hormone replacement. Therefore, these two variables had independent and additive effects. CEE and SPE increased SERT, and social status had no effect. Thus, the hormoneinduced increase in SERT was accompanied by increased 5-HT synthesis and neuronal firing, which appears biologically reasonable as 5-HT prevented SERT degradation in vitro.

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Section: Discussionmentioning

confidence: 65%

Soy and social stress affect serotonin neurotransmission in primates

Shively

Mirkes

et al. 2003

Pharmacogenomics J

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“…Further, there may be ER specific effects of E 2 to enhance learning. Ligands with specific activity at ERa or ERβ can enhance learning [43,50,71]. However, these data do not preclude non-ER mediated effects of E 2 to enhance learning.…”

Section: Discussionmentioning

confidence: 82%

Estradiol to aged female or male mice improves learning in inhibitory avoidance and water maze tasks

2005

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Although 17β-Estradiol (E 2 ) improves cognitive performance of aged female mice, its mnemonic effects when administered post-training to aged male mice have not been examined. E 2 (10 µg, SC) or oil vehicle was administered to intact, 24-month-old female or male congenic (primarily C57BL/6 background) mice immediately after training in the inhibitory avoidance or water maze tasks. Following behavioral testing, effects of 1 or 24 h of E 2 exposure on hippocampal levels of E 2 and brain-derived neurotrophic factor (BDNF) were examined. Female and male mice administered E 2 showed significantly better performance in the inhibitory avoidance task than did vehicle-administered mice. When tested 24 h after training, mice that received E 2 had significantly longer latencies to cross-over to the shock-associated side of the chamber than did vehicleadministered mice. Female or male mice administered E 2 showed significantly better performance in the reference memory aspect of the spatial water maze task. When tested 30 min after training, mice administered E 2 had shorter latencies to, and spent longer swimming in, the quadrant that the hidden platform had previously been located in. E 2 administration produced physiological levels of E 2 in the hippocampus 1 and 24 h after E 2 . BDNF levels in the hippocampus were decreased following 1 h of E 2 exposure compared to vehicle. These findings suggest that E 2 to female and male mice may overcome age-related deficits in reference memory in an emotional or spatial learning task.

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“…Although several studies have demonstrated effects of mixtures of flavonoids, including ginkgo biloba (24)(25)(26), soy isoflavones (27,28), or green tea polyphenols (29), on memory, the specific flavonoids producing this effect were not determined. Although studies with flavonoid mixtures have used biochemical, electrophysiological, or psychological assays to demonstrate effects on cognitive function, we are not aware of any study that has shown activity of a single flavonoid at all three levels, thereby providing an underlying mechanism for the observed action of the flavonoid.…”

Section: Discussionmentioning

confidence: 99%

Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory

Maher

Akaishi

Abe

2006

Proc. Natl. Acad. Sci. U.S.A.

281

197

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Small molecules that activate signaling pathways used by neurotrophic factors could be useful for treating CNS disorders. Here we show that the flavonoid fisetin activates ERK and induces cAMP response element-binding protein (CREB) phosphorylation in rat hippocampal slices, facilitates long-term potentiation in rat hippocampal slices, and enhances object recognition in mice. Together, these data demonstrate that the natural product fisetin can facilitate long-term memory, and therefore it may be useful for treating patients with memory disorders.cAMP response element-binding protein (CREB) ͉ phosphorylation ͉ learning ͉ polyphenol ͉ natural product

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Neurobehavioral effects of dietary soy phytoestrogens

Cited by 190 publications

References 127 publications

Soy and social stress affect serotonin neurotransmission in primates

Soy and social stress affect serotonin neurotransmission in primates

Estradiol to aged female or male mice improves learning in inhibitory avoidance and water maze tasks

Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory

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