Neurobehavioral Function in School-Age Children Exposed to Manganese in Drinking Water

Oulhote, Youssef; Mergler, Donna; Barbeau, Benoît; Bellinger, David C.; Bouffard, Thérèse; Brodeur, Marie-Ève; Saint-Amour, Dave; Legrand, Melissa; Sauvé, Sébastien; Bouchard, Maryse F.

doi:10.1289/ehp.1307918

Cited by 210 publications

(164 citation statements)

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“…Other cross-sectional epidemiologic studies have also observed sex-specific differences in associations between Mn levels measured in childhood and neurological outcomes (Bouchard et al 2011; Lucchini et al 2012a; Menezes-Filho et al 2014; Riojas-Rodriguez et al 2010; Torres-Agustín et al 2013), while some have not (Bouchard et al 2007; Chung et al 2015; Hernández-Bonilla et al 2011; Lucchini et al 2012b; Oulhote et al 2014a; Riojas-Rodriguez et al 2010). In 7–12 year-old girls living near Mn mining or ferro-manganese industry, hair Mn concentrations were negatively associated with scores on the Wechsler Intelligence Scale for Children (n=172) (Riojas-Rodríguez et al 2010), verbal learning and memory (Torres-Agustín et al 2013), and inattention and externalizing behavior (n=70)(Menezes-Filho et al 2014).…”

Section: Discussionmentioning

confidence: 94%

“…With one exception (Mora et al 2015), most epidemiologic studies that assessed childhood Mn exposure and learning and memory were cross-sectional in design and contained no prenatal or postnatal Mn measurements (Haynes et al 2015; Hernández-Bonilla et al 2016; Nascimento et al 2016; Oulhote et al 2014a; Torres-Agustín et al 2013; Wasserman et al 2011; Wright et al 2006). …”

Section: Introductionmentioning

confidence: 99%

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Manganese in teeth and neurobehavior: Sex-specific windows of susceptibility

Bauer

Henn

Austin

et al. 2017

Environment International

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Background Manganese (Mn) is an essential element required for growth and development, but higher body burdens have been associated with neurobehavioral decrements in children. Objectives We examined whether prenatal or postnatal Mn measured in deciduous teeth was associated with scores on a test of visuospatial learning and memory. Methods Deciduous teeth were collected from 142 participants (ages 10–14 years) residing near varied ferro-manganese industry in Italy. Mn concentrations were measured in prenatal and postnatal tooth regions by laser ablation inductively coupled plasma mass spectrometry (ICP-MS). The Virtual Radial Arm Maze (VRAM), an animal-human analogue task, was used to assess visuospatial learning and memory. We used generalized additive, linear and zero-inflated Poisson mixed regression models to estimate associations between prenatal or postnatal Mn concentrations and repeated measures of all four VRAM outcomes: time, distance, working and reference memory errors. Effect measure modification by sex was examined in stratified models. Results U-shaped associations between prenatal Mn and VRAM outcomes were observed among girls only (pGAMM =0.001 to 0.02 in stratified models). Compared to the mid-tertile of prenatal Mn, girls in the highest tertile took 7.7 seconds [95% CI: −6.1, 21.5] longer to complete the task, traveled 2.3 maze units [0.1, 4.4] farther, and committed more working and reference memory errors (β for count ratio=1.33 [1.01, 1.83]; 1.10 [0.98, 1.24], respectively). This association was not observed among boys. In contrast, for postnatal Mn, no significant associations were found, and patterns were similar for boys and girls. Conclusions The prenatal period may be a critical window for the impact of environmental Mn on visuospatial ability and executive function, especially for females.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Manganese in teeth and neurobehavior: Sex-specific windows of susceptibility

Bauer

Henn

Austin

et al. 2017

Environment International

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“…Oulhote et al (2014) reported a significant linear association between intake of Mn in drinking water and poorer motor function index, derived by a latent variable representing hand dexterity and coordination, in 6–13 year-old children in Canada (Oulhote et al, 2014a). Hernández-Bonilla et al found suggestive associations between higher blood Mn with poorer motor speed and coordination in children aged 7–11 years in Mexico, although not for hair Mn (Hernández-Bonilla et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Sex differences in sensitivity to prenatal and early childhood manganese exposure on neuromotor function in adolescents

Chiu

Henn

Hsu

et al. 2017

Environmental Research

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Introduction While studies have suggested that exposure to manganese (Mn) may be associated with neurodevelopment in school-age children, there is limited information on prenatal and postnatal Mn exposures and tremor or motor function in children. Methods We measured Mn levels in dentine of shed teeth, representing prenatal, early postnatal, and cumulative childhood exposure windows, from 195 children in Italy. Pursuit Aiming, Luria Nebraska Motor Battery, as well as Tremor and Sway system from Computerized Adaptive Testing System (CATSYS) were administered at 11–14 years old. We examined the relationships of tooth Mn (ln-transformed) with motor function using generalized linear models and generalized additive models, adjusting for age, sex, and socioeconomic status index. Effect modification by sex was also examined. Results We found that higher prenatal Mn was associated with better body stability in boys in a number of sway tests (including mean sway, transversal sway, sagittal sway, sway area, and sway intensity), while Mn was associated with poorer performance in girls on all of these metrics (all p for Mn × sex interaction <0.05). Higher prenatal Mn was also modestly associated with better hand/finger and eye-hand coordination in boys compared to girls in sex-stratified analyses, although interaction models did not reach statistical significance. For tremor, on the other hand, higher early postnatal Mn was associated with increased center frequency in girls (p for interaction<0.01), but increased Mn level at the later postnatal period was associated with increased center frequency in boys (p for interaction=0.01). Conclusions This study, which used a direct measure of prenatal and childhood Mn exposure, suggested sex-specific critical windows of early life Mn exposure in relation to neuromotor function in adolescents. The sex-specific associations might be strongest with measures of whole body stability, for which the critical exposure window was during the prenatal period.

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“…Mn is present ubiquitously in grains, green vegetables, fruits, nuts, spices, and tea and cases of Mn deficiency are uncommon (Roth, 2006). The presence of excessive Mn levels in drinking water or air has been associated with poorer memory and attention (Carvalho et al, 2014;Oulhote et al, 2014) and hyperactive behavior (Bouchard, 2007) in school-aged children. Water containing elevated Mn levels also had adverse effects on 10-year-old children's cognitive function (Wasserman et al, 2006).…”

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confidence: 99%