Neurobehavioral functioning in a nonconfounded group of asymptomatic HIV-seropositive homosexual men

Stern, Robert; Singer, Nicole; Silva, S. G.; Rogers, Heather; Perkins, Diana O.; Hall, Colin D.; Horst, Charles M. van der; Evans, Dwight L.

doi:10.1176/ajp.149.8.1099

Cited by 25 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We are unaware of any peer-reviewed studies of the BQSS or other qualitative metrics for understanding figure memory in HIV. The BQSS manual reports pilot data from 29 HIV-seronegative individuals and 29 medically asymptomatic men with HIV who were assessed in the era before combination antiretroviral therapies (cART; Stern et al, 1992). The pre-cART PWH sample reported in the manual showed difficulties with the configural and cluster elements of the figure copy, achieving lower scores on the copy measures of neatness, planning, and perseveration.…”

mentioning

confidence: 99%

A Process Analysis of Rey-Osterrieth Complex Figure Test Performance Using the Boston Qualitative Scoring System in HIV-Associated Neurocognitive Disorders

Morales Mejia,

Thompson,

Woods

2023

Percept Mot Skills

View full text Add to dashboard Cite

Deficits in episodic verbal memory are commonly observed in persons with HIV (PWH) disease, in whom they are characterized by dysregulation of the executive aspects of encoding and retrieval and adversely impact everyday functioning. Deficits in episodic visual memory are also apparent in PWH, but we know less about their cognitive architecture. This study used the Boston Qualitative Scoring System (BQSS) for the Rey-Osterrieth Complex Figure (ROCF) to examine visual learning and recall in 43 individuals without HIV and 141 PWH who completed a full research neuropsychological, psychiatric, and medical assessment. A mixed model covarying for education and estimated verbal IQ showed that participants with HIV-associated neurocognitive disorders (HAND) performed worse than PWH without neurocognitive disorders and HIV- participants at comparable medium-to-large effect sizes across the Copy, Immediate, and Delayed trials of the BQSS-ROCF, suggesting a primary encoding deficit. A component process analysis of the BQSS-ROCF Copy Trial revealed that participants with HAND had specific difficulties with configural accuracy, cluster accuracy, and cluster placement. Within the PWH sample, measures of motor coordination and executive functions emerged as independent predictors of BQSS-ROCF Copy Trial performance. Findings extend prior research by showing that HAND may be associated with a primary encoding deficit for complex visuomotor learning and memory tasks that is driven by a combination of visuospatial, motor, and executive difficulties.

show abstract

mentioning

confidence: 99%