Neurobehavioral performance of patients diagnosed with manganism and idiopathic Parkinson disease

Ellingsen, Dag G.; Shvartsman, G. I.; Bast‐Pettersen, Rita; Chashchin, Maxim; Thomassen, Yngvar; Chashchin, Valery

doi:10.1007/s00420-019-01415-6

Cited by 14 publications

(7 citation statements)

References 40 publications

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“…According to previous reports [25][26][27][28]41], we found a substantial loss of TH + neurons, as shown in Figures 6 and 7, displaying a very similar pattern to that reported in the middle to advanced stages of the PD; it has been described neurochemical variations in humans and animals Mn-intoxicated involving the decrease in dopamine concentration and TH + immunoreactivity in the SNc and striatum [13,15,16,[56][57][58][59]. Hence, it has been supposed that Mn interacts with catechols specific to dopaminergic neurons to diminish them promptly, causing these cells to no longer be viable [60,61].…”

Section: Tyrosine Hydroxylase Immunocytochemistrysupporting

confidence: 89%

Behavioral and Cytological Differences between Two Parkinson’s Disease Experimental Models

Avila-Costa¹,

Ordóñez-Librado²,

Gutiérrez-Valdez³

et al. 2023

Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials

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The knowledge about the biochemical and behavioral changes in humans with PD has allowed proposing animal models for its study; however, the results obtained so far have been heterogeneous. Recently, we established a novel PD model in rodents by manganese chloride (MnCl2) and manganese acetate (Mn (OAc)3) mixture inhalation. After inhaling, the rodents presented bilateral loss of SNc dopaminergic neurons. Later, we conclude that the alterations are of dopamine origin since L-DOPA reverted the alterations. After six months, SNc significantly reduced the number of cells, and striatal dopamine content decreased by 71%. The animals had postural instability, action tremor, and akinesia; these symptoms improved with L-DOPA, providing evidence that Mn mixture inhalation induces comparable alterations that those in PD patients. Thus, this study aimed to compare the alterations in two different PD experimental models: 6-OHDA unilateral lesion and Mn mixture inhalation through open field test, rotarod performance and the number of SNc dopaminergic neurons. The results show that the Mn-exposed animals have motor alterations and bilateral and progressive SNc neurons degeneration; in contrast, in the 6-OHDA model, the neuronal loss is unilateral and acute, demonstrating that the Mn exposure model better recreates the characteristics observed in PD patients.

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Section: Tyrosine Hydroxylase Immunocytochemistrysupporting

confidence: 89%

Behavioral and Cytological Differences between Two Parkinson’s Disease Experimental Models

Avila-Costa¹,

Ordóñez-Librado²,

Gutiérrez-Valdez³

et al. 2023

Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials

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“… 162 , 163 The experimental setup for balance testing is portable, sensitive enough to detect

error in field studies, and our methods are validated 37 , 51 , 164 and sensitive enough to effectively distinguish differences between patients exhibiting manganism and PD, something which is challenging to do clinically. 165 Our findings support postural balance as the standard test of neuromotor function to aid early detection of subclinical Mn neurotoxicity.…”

Section: Discussionsupporting

confidence: 68%

Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants

McBride,

Bhattacharya,

Sucharew

et al. 2024

Environ Health Perspect

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Background: Manganese (Mn) plays a significant role in both human health and global industries. Epidemiological studies of exposed populations demonstrate a dose-dependent association between Mn and neuromotor effects ranging from subclinical effects to a clinically defined syndrome. However, little is known about the relationship between early life Mn biomarkers and adolescent postural balance. Objectives: This study investigated the associations between childhood and adolescent Mn biomarkers and adolescent postural balance in participants from the longitudinal Marietta Communities Actively Researching Exposures Study (CARES) cohort. Methods: Participants were recruited into CARES when they were 7–9 y old, and reenrolled at 13–18 years of age. At both time points, participants provided samples of blood, hair, and toenails that were analyzed for blood Mn and lead (Pb), serum cotinine, hair Mn, and toenail Mn. In adolescence, participants completed a postural balance assessment. Greater sway indicates postural instability (harmful effect), whereas lesser sway indicates postural stability (beneficial effect). Multivariable linear regression models were conducted to investigate the associations between childhood and adolescent Mn biomarkers and adolescent postural balance adjusted for age, sex, height–weight ratio, parent/caregiver intelligence quotient, socioeconomic status, blood Pb, and serum cotinine. Results: CARES participants who completed the adolescent postural balance assessment ( ) were 98% White and 54% female and had a mean age of 16 y (range: 13–18 y). In both childhood and adolescence, higher Mn biomarker concentrations were significantly associated with greater adolescent sway measures. Supplemental analyses revealed sex-specific associations; higher childhood Mn biomarker concentrations were significantly associated with greater sway in females compared with males. Discussion: This study found childhood and adolescent Mn biomarkers were associated with subclinical neuromotor effects in adolescence. This study demonstrates postural balance as a sensitive measure to assess the association between Mn biomarkers and neuromotor function. https://doi.org/10.1289/EHP13381

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“…96−98 Its clinical symptoms are summarized in Table 3. In particular, this neurological disorder may be clinically mistaken for PD, because some motor symptoms are shared 94,95 (shared symptoms marked in Table 3).…”

Section: ■ Bioaccessibility Of Mnmentioning

confidence: 99%

“…Manganism is a neurodegenerative disorder caused by long-term exposure to Mn (usually by ingestion and/or inhalation). Studies have shown that this condition is characterized by impaired motor skills and cognitive disorders − and is linked to Mn accumulation in the brain that results in dopaminergic neurodegeneration, predominantly in the basal ganglia region. − Its clinical symptoms are summarized in Table . In particular, this neurological disorder may be clinically mistaken for PD, because some motor symptoms are shared , (shared symptoms marked in Table ).…”

Section: Manganismmentioning

confidence: 99%

Manganese in the Diet: Bioaccessibility, Adequate Intake, and Neurotoxicological Effects

Martins

Krum

Queirós

et al. 2020

J. Agric. Food Chem.

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Manganese (Mn) is an essential element that participates in several biological processes. Mn serves as a cofactor for several enzymes, such as glutamine synthetase and oxidoreductases, that have an important role in the defense of the organisms against oxidative stress. The diet is the main source of Mn intake for humans, and adequate daily intake levels for this metal change with age. Moreover, in higher amounts, Mn may be toxic, mainly to the brain. Here, we provide an overview of Mn occurrence in food, addressing its bioaccessibility and discussing the dietary standard and recommended intake of Mn consumption. In addition, we review some mechanisms underlying Mn-induced neurotoxicity.

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Neurobehavioral performance of patients diagnosed with manganism and idiopathic Parkinson disease

Cited by 14 publications

References 40 publications

Behavioral and Cytological Differences between Two Parkinson’s Disease Experimental Models

Behavioral and Cytological Differences between Two Parkinson’s Disease Experimental Models

Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants

Manganese in the Diet: Bioaccessibility, Adequate Intake, and Neurotoxicological Effects

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